Rachel Baldwin‐Cleland
A5102768478- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Microscopic Colitis
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Carcinogens and Genotoxicity Assessment
- Diagnosis and treatment of tuberculosis
- Global Cancer Incidence and Screening
- Frailty in Older Adults
- DNA Repair Mechanisms
- Multiple and Secondary Primary Cancers
- Venous Thromboembolism Diagnosis and Management
- Clinical Nutrition and Gastroenterology
St Mark's Hospital
2016-2025
London North West Healthcare NHS Trust
2016-2024
National Health Service
2018-2024
Portsmouth Hospitals NHS Trust
2022
University College London
2022
University Hospitals of North Midlands NHS Trust
2022
Southmead Hospital
2022
Amersham Hospital
2022
Royal Berkshire NHS Foundation Trust
2022
Magnetic resonance enterography (MRE) and ultrasound are used to image Crohn's disease, but their comparative accuracy for assessing disease extent activity is not known with certainty. Therefore, we did a multicentre trial address this issue.
Abstract Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients difficult and complicates treatment strategy. We aimed to determine if motility magnetic resonance imaging (mMRI) superior CRP fecal calprotectin (FC) the prediction of RoR at 1 year in commencing biologics SBCD. Methods Prospective, multicenter (n = 13) cohort study active non-stricturing SBCD requiring anti-TNFα...
Abstract Objectives Altered body fat and muscle mass in Crohn’s disease (CD) have been linked to adverse course outcomes. Prediction of treatment response or remission (RoR) small bowel CD (SBCD) biologic therapy remains challenging. We aimed establish the prognostic value composition parameters measured using MR enterography (MRE) for RoR at 1 year patients with SBCD commencing therapy. Methods Participants were identified from those recruited a prospective, multicentre study investigating...
Background Most radiologists reporting CT colonography (CTC) do not undergo compulsory performance accreditation, potentially lowering diagnostic sensitivity. Purpose To determine whether 1-day individualized training in CTC improves sensitivity of experienced for 6-mm or larger lesions, the durability any improvement, and associated factors. Materials Methods This prospective, multicenter cluster-randomized controlled trial was performed National Health Service hospitals England Wales...
The simplified magnetic resonance enterography [MRE] index of activity [sMARIA], London, and 'extended' scoring systems are widely used in Crohn's disease [CD] to assess activity, although validation studies have usually been single-centre, retrospective, and/or few readers. Here, we evaluated these MRE indices within a prospective, multicentre, multireader, diagnostic accuracy trial.A subset participants [newly diagnosed or suspected relapse] recruited the METRIC trial with available...
Sahnan, Kapil BSc (Hons), MBBS, MRCS; Adegbola, Samuel O. Tozer, Phillip J. MD, MCEM, FRCS; Gupta, Arun MBChB, MRCP, FRCR; Baldwin-Cleland, Rachel MSc; Yassin, Nuha MRCS, PhD; Warusavitarne, Janindra BMed, FRACS, Faiz, Omar D. FRCS, MS; Hart, Ailsa L. BA BMBCh, FRCP, Phillips, Robin K. S. Lung, F. C. FRCR Author Information
Magnetic resonance enterography and enteric ultrasonography are used to image Crohn's disease patients. Their diagnostic accuracy for presence, extent activity of was compared. To compare accuracy, observer variability, acceptability, impact cost-effectiveness magnetic in newly diagnosed or relapsing disease. Prospective multicentre cohort study. Eight NHS hospitals. Consecutive participants aged ≥ 16 years, with established suspected relapse. ultrasonography. The primary outcome...
Perianal Crohn’s Disease (pCD) is a common manifestation of Disease. Absence reliable disease measures makes monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and pCD shown potential assessing response to treatment. Quantitative sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) magnetisation transfer (MT), along with T2 relaxometry, offer opportunities improve diagnostic capability. sequences (DWI, DCE, MT T2) were in...
Perianal Crohn's fistula and their response to anti-tumour necrosis factor (TNF) therapies are best assessed with magnetic resonance imaging (MRI), but radiologist reporting is subjective variable. This study investigates whether segmentation software could provide precise reproducible objective measurements of volume.Retrospective analysis patients perianal at our institution between 2007 2013. Pre- post-biologic MRI scans were used varying time intervals. A total two radiologists recorded...
Anastomotic leak causes significant morbidity for patients undergoing pelvic intestinal surgery. Fluoroscopic assessment of anastomotic integrity using water-soluble contrast enema (WSCE) is questionable benefit over examination alone. We hypothesized that MRI-enema may be more accurate. The aim this study was to compare with fluoroscopic WSCE.Patients referred WSCE anastomosis and defunctioning ileostomy (including suspected or known leaks) were invited participate. undertaken within 48 h...
Introduction Lynch syndrome patients have an inherited predisposition to cancer due a deficiency in DNA mismatch repair (MMR) genes which could lead higher risk of developing if exposed ionizing radiation. This pilot study aims reveal the association between MMR and radiosensitivity at both CT relevant low dose (20 mGy) therapeutic (2 Gy). Methods Human colorectal cell lines with (dMMR) or without (pMMR) were analyzed before after exposure radiation using cellular cytogenetic analyses i.e.,...
ABSTRACT Background Colorectal cancer (CRC) is a common, important healthcare priority and improving patient outcome relies on early diagnosis. Colonoscopy computed tomographic colonography (CTC) are commonly-used diagnostic tests. Although colonoscopists highly regulated must be accredited, no analogous process exists for CTC. There currently universally accepted radiologist performance indicators CTC, lack of regulatory oversight may lead to variability in quality lower neoplasia detection...