A5010267353- Gallbladder and Bile Duct Disorders
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Appendicitis Diagnosis and Management
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Microscopic Colitis
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Porphyrin and Phthalocyanine Chemistry
- Pancreatic and Hepatic Oncology Research
- Biliary and Gastrointestinal Fistulas
- Cancer and Skin Lesions
- Medical Imaging Techniques and Applications
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nonmelanoma Skin Cancer Studies
- Nutrition and Health in Aging
- COVID-19 diagnosis using AI
- MRI in cancer diagnosis
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Royal London Hospital
2025
University College London
2018-2025
University College Hospital
2021-2025
Osaka Prefectural Medical Center
2024
University of Geneva
2023-2024
Centre for Sight
2018
Luton and Dunstable University Hospital NHS Foundation Trust
2016
Luton and Dunstable Hospital
2014-2016
University of Cambridge
2013
Nara Women's University
2004-2008
Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita (catheter system)), on glycaemic control liver fat content in type 2 diabetes (T2D).Eligible patients (haemoglobin A1c (HbA1c) 59-86 mmol/mol, body mass index≥24 ≤40 kg/m2, fasting insulin >48.6 pmol/L, ≥1 oral antidiabetic medication) enrolled Europe...
Abstract Objectives Predicting longer term response to biological therapy for small bowel Crohn’s disease (SBCD) is an unmet clinical need. Diffusion-weighted MR imaging (DWI) may indicate activity, but its predictive ability, if any, unknown. We investigated the prognostic value of DWI one year or remission (RoR) in SBCD patients commencing biologic therapy, including incremental over C-reactive protein (CRP) and faecal calprotectin (FC). Methods A subset participants a prospective,...
Abstract Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients difficult and complicates treatment strategy. We aimed to determine if motility magnetic resonance imaging (mMRI) superior CRP fecal calprotectin (FC) the prediction of RoR at 1 year in commencing biologics SBCD. Methods Prospective, multicenter (n = 13) cohort study active non-stricturing SBCD requiring anti-TNFα...
Abstract Objectives Altered body fat and muscle mass in Crohn’s disease (CD) have been linked to adverse course outcomes. Prediction of treatment response or remission (RoR) small bowel CD (SBCD) biologic therapy remains challenging. We aimed establish the prognostic value composition parameters measured using MR enterography (MRE) for RoR at 1 year patients with SBCD commencing therapy. Methods Participants were identified from those recruited a prospective, multicentre study investigating...
To demonstrate proof-of-concept for a quantitative MRI method using histographic analysis to assess bone marrow oedema and fat metaplasia in the sacroiliac joints.Fifty-three adolescents aged 12-23 with known or suspected sacroiliitis were prospectively recruited underwent (qMRI) scans, consisting of chemical shift-encoded (at 3 T) diffusion-weighted imaging 1.5 T), plus conventional clinical assessment. qMRI scans produced proton-density fraction (PDFF) apparent diffusion coefficient (ADC)...
Purpose To evaluate the relationship between bone mineral density (BMD) and magnetic susceptibility, proton fat fraction in inflamed trabecular bone. Methods Two different phantoms modeling (FF) BMD values of healthy marrow disease states were scanned using a multiecho gradient echo acquisition at 3T. After correction for fat‐water chemical shift, susceptibility mapping was performed, measurements compared with FF linear regression. Patients spondyloarthritis same protocol, calculated areas...
Abstract Electrophoretic karyotype studies have shown that clinical isolates of Candida albicans extensive chromosome length polymorphisms. Chromosome translocation is one the causes karyotypic variation. events been to occur very frequently at or near major repeat sequence (MRS) on chromosomes. The MRS consists repeated sequences RB2, RPS and HOK, are considered be template for recombination. To investigate which element important translocation, we constructed three cassettes, each...
Objective assessments of disease activity and response to treatment in axial spondyloarthritis (axSpA) remain a challenge; quantitative imaging biomarkers (QIBs) inflammation could enhance therapeutic response. We aimed determine the responsiveness QIBs obtained from diffusion-weighted (DW-MRI) chemical shift-encoded MRI (CSE-MRI) using partially automated Bone Edema Adiposity Characterisation with Histograms (BEACH) software tool axSpA patients undergoing biologic therapy.We conducted...
Remission of type 2 diabetes (T2D) can be achieved by many, but not all, people following bariatric/metabolic surgery. The mechanisms underlying T2D remission remain incompletely understood. This observational study aimed to identify novel weight-loss independent clinical, metabolic and genetic factors that associate with using comprehensive phenotyping.Ten patients without (non-remitters) were matched 10 (remitters) for age, sex, surgery, body weight, BMI, post-operative weight loss,...
<h3>Background</h3> Magnetic resonance imaging (MRI) is an important part of diagnostic pathways in spondyloarthritis (SpA), and can be used to stratify patients assess severity. However, measurements the burden inflammation currently rely on qualitative assessment, which subjective time-consuming thus impractical for clinical practice. There a need more objective, faster method measuring damage with potential automation, quantitative MRI candidate tool. <h3>Objectives</h3> We aimed provide...
Diffusion‐weighted imaging has received attention as a method for characterizing inflammatory exudates in bone marrow immune‐mediated diseases and reveals an increase diffusivity regions of oedema. Various models diffusion attenuation have been investigated but the model providing best description tissue pathophysiology oedema is unknown. Determining most appropriate important step towards protocol optimization development robust clinically useful method. We aimed to determine which three...
To increase responsiveness to membrane tension, subphthalocyanine-flipper dyads combine bright, long-lifetime mechanophores in ordered domains with anisotropically, environment-insensitive, short-lifetime enhancers disordered domains.
胆管気管支瘻は胆汁が気管支に流出する稀な疾患であり,化学性肺炎を引き起こし治療に難渋する場合が多く,治療法は確立されていない。今回我々が経験した症例は82歳,男性。 肝細胞癌治療後に胆管気管支瘻を発症し,慢性気道感染を繰り返していた。横隔膜ヘルニアを併発しており,手術侵襲や合併症のリスクを考慮して外科的根治術は困難であると判断した。姑息的に胆管外瘻チューブを留置していたが,チューブ閉塞に伴い胆汁流出による化学性肺炎を発症した。呼吸状態が悪化したためICUに入室し,健側肺保護のためにダブルルーメンチューブを用いて分離肺換気で管理した。胆管外瘻チューブを交換後,気管支鏡で胆汁流出の程度を評価しながら人工呼吸器設定や体位交換,経腸栄養開始時期などを検討することで肺炎増悪を防ぎ良好な経過を辿った。胆管気管支瘻による化学性肺炎では,外瘻を確立させて速やかに胆汁流出量を減少させ,分離肺換気で健側肺を保護することが重要である。
Objectives: To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal using whole-body MRI relate this to clinical outcomes. Methods: 53 NSCLC (28 males, 25 females; mean age 66.9) 74 (42 32 62.9) underwent staging scans, which were post-processed derive fat mass (FM), free (FFM) skeletal muscle (SM) indices SM fraction (FF). These compared between the two cohorts two-sided t-tests chi-squared test. Measurements of correlated outcomes including length...
To evaluate the association between image quality of cancer staging whole-body magnetic resonance imaging (WB-MRI) and patient demographics, distress, perceived scan burden.
The authors present an unusual case of small bowel obstruction in a 62-year-old man.A man with background transitional cell carcinoma (TCC) the bladder presented to emergency department abdominal pain, distension, vomiting and had not opened his bowels for three days. 3 weeks previously he repeat Transurtheral resection tumour (TURBT), during which there was iatrogenic perforation bladder. A CT scan abdomen pelvis revealed but did identify cause. At laparotomy cause identified as section...
We report the results of a joint thyroid clinic with consultant surgeon and radiologist to offer “triple assessment” for patients on single visit. All new referrals from September 2011 December 2013 were reviewed. Among 228 referred, 163 underwent ultrasonography (US) same visit 66 fine needle aspiration cytology (FNAC) studies (57 under US guidance) done. One hundred ninety-eight (87%) made diagnosis. twenty-five discharged or referred elsewhere after 21 surgery; remaining 52 followed up....