A5027498764- Neuropeptides and Animal Physiology
- Cardiac Health and Mental Health
- Receptor Mechanisms and Signaling
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Intensive Care Unit Cognitive Disorders
- Pharmacological Receptor Mechanisms and Effects
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Medication Adherence and Compliance
- Stress Responses and Cortisol
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Mindfulness and Compassion Interventions
- Cardiovascular Function and Risk Factors
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Stroke Rehabilitation and Recovery
Kent State University
2016-2025
Jensen Hughes (United States)
2006-2024
Imperial College London
1978-2024
Örebro University
2024
University College London
2019-2023
University Hospitals of Leicester NHS Trust
2023
Manchester University NHS Foundation Trust
2023
NIHR Leicester Biomedical Research Centre
2021-2023
University of Leicester
2021-2023
MRC University of Glasgow Centre for Virus Research
2023
PD134308 and PD135158 are potent selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50 values of 1.6 nM 3.5 nM, respectively, in radioligand binding assay Ke 7.82 12.9 their blocking action on CCK responses rat lateral hypothalamic slice. produced anxiolytic effects mouse black/white box test after either subcutaneous or oral administration. There was no evidence development tolerance to mice treated twice daily for 7 days, nor there any sign withdrawal anxiogenesis...
A method is described for the rapid extraction of opioid peptides from brain and other tissues. The based on acid tissues followed by adsorption extract onto Amberlite XAD‐2 resin. Elution with methanol separates enkephalins α‐endorphin β‐endorphin. Over 90% peptide activity isolated gut several species our was due to methionine‐ leucine‐enkephalin. In contrast, major recovered pituitary much greater mol. wt. than enkephalins. An properties unlike those known endorphins or present in...
Morphine inhibits the electrically evoked (0.1‐0.15 Hz, 1 ms) contractions of longitudinal muscle mouse vas deferens but not rabbit, guinea‐pig, rat, cat, hamster or gerbil. This effect is stereospecific and antagonized by naloxone naltrexone. Normorphine equiactive with morphine its effects are more rapid in onset decline. In deferens, resting outflow tritium‐labelled catecholamines unaffected morphine. The depressed normorphine a dose‐dependent manner. ID 50 for inhibition contraction...
The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0 5 ,UM).This effect is mediated specific receptors are blocked naloxone.Activation the inhibits noradrenaline release.It concluded that neurotransmission in differs some important way from at more common, morphine-insensitive, junctions.
Gabapentin (neurontin) is a novel antiepileptic agent that binds to the α 2 δ subunit of voltage‐dependent calcium channels. The only other compound known possess affinity for this recognition site ( S )‐(+)‐enantiomer 3‐isobutylgaba. However, corresponding R )‐(−)‐enantiomer 10 fold weaker. present study evaluates activity gabapentin and two enantiomers 3‐isobutylgaba in formalin carrageenan‐induced inflammatory pain models. In rat test, ‐(+)‐3‐isobutylgaba (1–100 mg kg −1 ) (10–300...
The purpose of this study was to examine the relationships between depressed mood and parasympathetic control heart in healthy men women at rest during two stressors.Fifty-three college students completed a laboratory stress protocol that included baseline resting period, challenging speech task, forehead cold pressor task. Depressed assessed using Beck Depression Inventory (BDI). Parasympathetic cardiac measured as high-frequency (0.12-0.40 Hz) component (HF) rate variability power spectrum...
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model anxiety. selective CCK-B CI-988 (PD 134308) L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A antagonist, respectively less potent by factors 313 200. intracerebroventricular administration nonselective CCK agonist caerulein or pentagastrin increased dose dependently level antagonized anxiogenic response to but not that induced pentylenetetrazol....
Nociceptive thresholds to noxious mechanical (paw pressure) and thermal (tail flick) stimuli were recorded in conscious rats. The effects of three selective κ‐opioid receptor agonists on the responses these determined following intravenous, intracerebroventricular or intrathecal administration. Results compared with those obtained morphine. Following intravenous administration PD117302, U50488, U69593 morphine produced steep parallel dose‐response curves indicating antinociceptive activity...
1. The effects of angiotensin on the contractility transmurally stimulated rabbit portal vein and coeliac artery have been studied in conjunction with its release uptake (+/-)-(3)H-noradrenaline.2. Angiotensin contracted both artery; these responses were enhanced by veratrine reduced tetradotoxin. At low (non-contractile) concentrations angiotensin, contractions elicited electrical stimulation (0.5-4 Hz) had a quicker onset reached higher maximal tension than control responses. Higher...
The effects of systemic PD134308 [0.1-3 mg/kg; an antagonist the cholecystokinin (CCK) type B receptor], morphine, and intrathecal (i.t.) galanin (GAL) on excitability spinal nociceptive flexor reflex in hot plate test were examined rats. caused a weak naloxone-reversible depression moderate antinociceptive effect test. However, significantly potentiated morphine as well its depressive reflex. i.t. GAL synergistically depressed reflex, that was reversed by naloxone. Finally, magnitude...
1. To determine the role of endogenous cholecystokinin (CCK) in regulation food intake, effects potent CCK receptor antagonist L364,718 were investigated on intake a palatable diet non-deprived rats. The effect single dose proglumide was also for comparative purposes. In addition, ability to antagonize reduction produced by exogenous cholecystokinin-octapeptide (CCK8) or bombesin food-deprived rats determined. 2. (10-100 micrograms kg-1, i.p.) increased during 30 min test period. Proglumide...
Objective Mindfulness-based stress reduction (MBSR) is an increasingly popular practice demonstrated to alleviate and treat certain health conditions. MBSR may reduce elevated blood pressure (BP). Treatment guidelines recommend life-style modifications for BP in the prehypertensive range (systolic [SBP] 120–139 mm Hg or diastolic [DBP] 80–89 Hg), followed by antihypertensives if reaches hypertensive levels. has not been thoroughly evaluated as a treatment of prehypertension. A randomized...
1. A method is described for the detection and assay of picogramme quantities noradrenaline. This involves transferring Krebs solution containing noradrenaline to a cascade system where catecholamine may be bioassayed on superfused preparations rabbit aorta iliac artery.2. Electrical field stimulation vas deferens portal vein caused release, into bathing medium, material which was identified by pharmacological chemical tests as noradrenaline.3. Cocaine (0.3-5 mug/ml) marked increase in...
Objective Treatment recommendation and guidelines for patients with heart failure (HF) can be complex, past work has shown that HF demonstrate low rates of adherence to recommended health behaviors. Although previous identified several medical, demographic, psychosocial predictors the capacity adhere treatment recommendations persons HF, little is known about contribution cognitive impairment reported in this population. Methods A total 149 (mean [standard deviation] = 68.08 [10.74] years)...