Background and aims: Alcohol overconsumption is a risk factor for disease progression in patients with presumed metabolic dysfunction-associated steatotic liver (MASLD).How commonly this occurs how it affects to major adverse outcomes (MALO) not well known.Methods: We did register-based cohort study, including all diagnosis of MASLD Sweden between 1987 2020.Patients were stratified on cooccurrence diagnoses alcohol-related (ALD) or alcohol use disorder (AUD) prior diagnosis.Incident MALO:s...

Although many studies indicate the interplay of genetic and environmental factors in etiology autism spectrum disorder (ASD), our limited understanding underlying mechanisms hampers development effective ways detecting preventing disorder. Recent support hypothesis that prenatal androgen exposure contributes to ASD. This would suggest maternal polycystic ovary syndrome (PCOS), a condition associated with excess androgens, increase risk ASD offspring. We conducted matched case–control study...

<h3>Importance</h3> Familial aggregation of mental and neurological disorders is often observed in autism spectrum (ASD), but reports have generally focused on single are limited to first-degree relatives. <h3>Objectives</h3> To examine family history among first- fourth-degree relatives risk ASD with without intellectual disability (ID) index persons. <h3>Design, Setting, Participants</h3> In this population-based cohort study, 567 436 persons were identified from the Stockholm Youth...

Individuals with non-alcoholic fatty liver disease (NAFLD) may be at greater risk of cancer. This study aimed to investigate the hepatic and extrahepatic cancer compared general population in a population-based cohort patients NAFLD.

Nonalcoholic fatty liver disease (NAFLD) and dementia share common risk factors including metabolic disorders. However, whether NAFLD is associated with unclear. We investigated the association between as well role of cardiovascular complications heart stroke.In this population-based matched cohort study, we identified all Swedish patients aged 65 years or older from National Patient Register (NPR) 1987 2016. These were up to 10 reference individuals general population on age, sex,...

Abstract Background and Aims Conflicting evidence exists on cardiovascular disease (CVD) risk in patients with NAFLD, data are lacking whether NAFLD increases mortality after a CVD event. Moreover, life expectancy has not been studied. We therefore examined compared the general population. Approach Results In this nationwide population‐based cohort, all diagnosis without baseline (ascertaining from Swedish National Patient Register 1987 to 2016, n = 10,023) were matched 10:1 age, sex,...

Epidemiological data on mortality in autoimmune liver diseases (AILDs) are scarce. We examined all-cause and cancer-related individuals with AILD from Sweden. identified 9654 (3342 hepatitis (AIH), 3751 primary biliary cholangitis (PBC), 2561 sclerosing (PSC)) using national Swedish registries between 2001 2020. These were matched 80 685 comparators the general population at a ratio of 1:10 age, sex, year diagnosis municipality. Rates outcomes estimated Cox regression models, adjusted for...

Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder, and boys are two to three times more likely develop ADHD. Maternal polycystic ovary syndrome (PCOS), a metabolic associated with excess circulating androgens, has been increased risk for autism spectrum in offspring. In this study, we aimed investigate whether maternal PCOS increases ADHD offspring.We conducted matched case-control study using health population data registers all...

Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability not well understood. In this population‐based cohort study, we examined the of ASD with without co‐occurring intellectual disability (ID). We estimated odds ratios ID (ASD+ID) (ASD−ID) using register‐based diagnosis data 567,436 index persons born in 1984–2009 Stockholm County, Sweden, their parents, siblings, cousins, aunts, uncles. The profile exhibited differences...

Abstract Background Current risk estimates for hepatocellular carcinoma (HCC) in individuals with cirrhosis vary between studies. The has mostly been evaluated single etiologies separately. Objectives We examined the of HCC Swedish outpatients a new diagnosis cirrhosis, aiming to identify subgroups particularly high incident HCC. Methods All patients first National Outpatient Register whom etiology could be estimated were identified. Incident cases ascertained until end 2016 using record...

Swedish nationwide registries can be used to identify patients with a wide range of diagnoses. This information construct cohorts useful determine prognosis and risk factors for disease progression. Here, we describe new register-based cohort diverse set chronic liver diagnoses in Sweden.The DELIVER (DEcoding the epidemiology LIVER sweden) was constructed using extensive data linkages between different registers, diagnosed 1964 2016. Patients are matched 1:10 reference individuals from...

Excessive gestational weight gain is common and associated with adverse outcomes both in the short long term. Although traditional lifestyle-based interventions have shown to mitigate excess gain, little known about whether mobile Health (mHealth) apps can promote healthy diet, physical activity during pregnancy.The primary aim of HealthyMoms trial determine effectiveness a smartphone app (HealthyMoms) for mitigating pregnancy. Secondary aims are on dietary habits, activity, body fatness,...

•The link between NAFLD and dementia is unclear.•We assessed the association biopsy-proven dementia.•NAFLD not associated with an increased risk of dementia.•Adding histological markers to a conventional model for enhanced its predictive capacity. Background & AimsNon-alcoholic fatty liver disease (NAFLD) common in general population, but unclear. We aimed assess related NAFLD, determine whether parameters could improve capacity patients NAFLD.MethodsA retrospective matched cohort study 656...

Previous literature suggests an association between non-alcoholic fatty liver disease (NAFLD) and infections. We aimed to determine the rate risk of severe infections in NAFLD compared general population.In this population-based cohort study, we used national registers identify all patients with a hospital-based diagnosis Sweden 1987-2020 (n = 14 869). The were matched ≤10 comparators from population for age, sex, municipality, calendar year 137 145). Cox regression was estimate hazard...

ABSTRACT Background and Aims Timely transition of care amongst patients with a first diagnosis cirrhosis in hospital to an outpatient visit is important. We evaluated rates follow‐up after during inpatient setting, its association subsequent rehospitalisation mortality. Methods conducted population‐based cohort study identifying all hospitalised Sweden diagnosed between 2002 2020 from the Swedish National Patient Register. The primary outcome was any related within 90 days discharge....

Abstract Objective To estimate the incidence, prevalence, and outcomes of patients with diagnosed alpha‐1‐antitrypsin deficiency (AATD) in Sweden, 2002–2020. Study design setting The Swedish National Patient Registry was utilized to identify a first diagnosis AATD between 2002 2020. Each patient matched up 10 comparators from general population. incidence prevalence were estimated. Causes death rates mortality, transplantation, lung disease, liver cirrhosis, previous neonatal cholestasis...

It is unclear if the risk of hepatic decompensation or hepatocellular carcinoma (HCC) differs between patients with compensated alcohol-related liver disease (ALD)- and metabolic dysfunction-associated steatotic (MASLD)-cirrhosis. We investigated to develop HCC based on ALD MASLD as underlying etiology cirrhosis. All a new diagnosis in hospital-based outpatient care ALD- MASLD-cirrhosis Sweden 2002 2020 were identified using national registers. Hepatic was analyzed composite outcome HCC. Cox...

Background & AimsThe rate of postcolonoscopy colorectal cancer (PCCRC) is a measure colonoscopy quality, but there are conflicting results from studies survival times patients with PCCRC. We assessed PCCRC and characterized the microscopic macroscopic features tumors.MethodsWe performed population-based cohort study using data database in Sweden, on 458,937 colonoscopies (54.0% women) 2003 through 2012. Rates within 3 years were calculated based World Endoscopy Organization guidelines. Risk...

Nonalcoholic fatty liver disease (NAFLD) is considered a multisystem disease, as it bidirectionally linked to other cardiometabolic disorders, such type 2 diabetes (T2D). However, the long-term risk for microvascular outcomes in NAFLD unclear.Using outpatient part of nationwide Swedish Patient Register time period between 01/01/2002 and 12/31/2019, we identified all individuals with first diagnosis (N = 6785) matched these (age, sex, municipality) up 10 reference from general population...

Clozapine treatment may have beneficial effects on behavioral outcomes in psychotic disorders, including violent offending. Although clozapine and other antipsychotics been linked to lower levels of behavior, these primarily small selected samples, population-based estimates limited imprecise. We aimed assess the effect rate nonviolent carried out a within-person mirror-image study Swedish population with prescription, hospitalization, sociodemographic registers. Outcomes were violent,...

Background and AimsSecondary prevention of esophageal variceal bleeding is important to improve prognosis, but uptake guidelines unknown in a real-world setting. Here, we determined the proportion patients receiving appropriate nonselective beta-blocker treatment repeat upper endoscopy after first episode within reasonable time frame.MethodsPopulation-based registers were used identify all with Sweden from 2006 2020. Crosslinkage between was performed receive information on cumulative...

Summary Both short (&lt; 6 hr) and long (&gt; 8 sleep are associated with increased mortality. We here investigated whether the association between duration all‐cause, cardiovascular disease cancer mortality differs men women. A cohort of 34,311 participants (mean age standard deviation = 50.5 ± 15.5 years, 65% women), detailed assessment at baseline up to 20.5 years follow‐up (18 for cause‐specific mortality), was analysed using Cox proportional hazards model estimate HRs 95% confidence...

Few studies have investigated mortality rates in patients with Wilson's disease and compared these to the general population. Here, we examined several clinical outcomes (including cardiovascular, psychiatric, neurologic conditions) a population-based study of disease.We used nationwide registers identify all first diagnosis between 2002 2020 Sweden. Each patient was matched by age, sex, municipality up 10 reference individuals from Validated were investigate 19 years after baseline...