A5047653896- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Genetics and Neurodevelopmental Disorders
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Adolescent and Pediatric Healthcare
- Health, Environment, Cognitive Aging
- Pregnancy and Medication Impact
- Vaccine Coverage and Hesitancy
- Advanced Causal Inference Techniques
- Organ Donation and Transplantation
- Child Development and Digital Technology
- Health disparities and outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Renal Transplantation Outcomes and Treatments
- Obesity, Physical Activity, Diet
- Breastfeeding Practices and Influences
- Gestational Diabetes Research and Management
- Pharmacological Effects and Toxicity Studies
- Insect Pheromone Research and Control
- Virology and Viral Diseases
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
Karolinska Institutet
2014-2024
Drexel University
2015-2024
Seton Medical Center
2021-2024
University of Bristol
2017-2024
Medical Research Council
2024
Seton Medical Center Austin
2021-2024
NewYork–Presbyterian Brooklyn Methodist Hospital
2024
Google (United States)
2020-2023
Brain (Germany)
2020-2023
The University of Texas at Austin
2023
Abstract Machine learning techniques such as classification and regression trees (CART) have been suggested promising alternatives to logistic for the estimation of propensity scores. The authors examined performance various CART‐based score models using simulated data. Hypothetical studies varying sample sizes ( n =500, 1000, 2000) with a binary exposure, continuous outcome, 10 covariates were under seven scenarios differing by degree non‐linear non‐additive associations between exposure....
ObjectiveExamining covariate balance is the prescribed method for determining degree to which propensity score methods should be successful at reducing bias. This study assessed performance of various measures, including a proposed measure based on prognostic (similar disease risk score), determine measures best correlate with bias in treatment effect estimate.Study Design and SettingThe correlations multiple common estimate produced by weighting odds, subclassification score, full matching...
Individuals with mental disorders often develop comorbidity over time. Past studies of have restricted analyses to a subset and few provided absolute risks later comorbidity.To undertake comprehensive study within disorders, by providing temporally ordered age- sex-specific pairwise estimates between the major groups an interactive website visualize all results guide future research clinical practice.This population-based cohort included individuals born in Denmark January 1, 1900, December...
Propensity score weighting is sensitive to model misspecification and outlying weights that can unduly influence results. The authors investigated whether trimming large downward improve the performance of propensity benefits differ by estimation method. In a simulation study, examined weight following logistic regression, classification regression trees (CART), boosted CART, random forests estimate weights. Results indicate although misspecified models yield increased bias standard errors,...
To study the association between parental depression and maternal antidepressant use during pregnancy with autism spectrum disorders in offspring.Population based nested case-control study.Stockholm County, Sweden, 2001-07.4429 cases of disorder (1828 2601 without intellectual disability) 43,277 age sex matched controls full sample (1679 16,845 data on within a cohort (n=589,114) young people aged 0-17 years.A diagnosis disorder, or disability.Parental other characteristics prospectively...
Objective Reports of rising prevalence autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need methodologically sound studies to explore causes consequences. We here present design a large intergenerational resource for ASD research, population-based estimates diagnostic validity. Method The Stockholm Youth Cohort is record-linkage study comprising all individuals aged 0–17 years, ever resident in County 2001–2007 (N = 589,114). cases...
<h3>Importance</h3> Given the critical role that iron plays in neurodevelopment, an association between prenatal deficiency and later risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), intellectual disability (ID), is plausible. <h3>Objective</h3> To test a priori hypothesis anemia diagnosed mothers during pregnancy associated with increased ASD, ADHD, ID offspring magnitude varies regard to timing pregnancy. <h3>Design,...
Importance Several studies suggest that acetaminophen (paracetamol) use during pregnancy may increase risk of neurodevelopmental disorders in children. If true, this would have substantial implications for management pain and fever pregnancy. Objective To examine the associations with children’s autism, attention-deficit/hyperactivity disorder (ADHD), intellectual disability. Design, Setting, Participants This nationwide cohort study sibling control analysis included a population-based...
<h3>Context</h3> The stress responses of the hypothalamic-pituitary-adrenal axis can produce adverse effects on brain. Previous studies have concluded that an elevated level cortisol is a risk factor for cognitive dysfunction and decline in aging but been limited by sex exclusion, restricted batteries, small sample sizes. <h3>Objective</h3> To examine associations among salivary metrics domain scores urban adult population. <h3>Design, Setting, Participants</h3> A cross-sectional analysis...
Background: The objectives of this study were to examine the independent and dependent associations maternal paternal age risk offspring autism spectrum disorders (ASD), with without intellectual disability (ID). Methods: sample consisted 417 303 Swedish children born 1984–2003. ASD case status (N = 4746) was ascertained using national regional registers. Smoothing splines in generalized additive models used estimate parental ASD. Results: Whereas advancing increased child ASD, effects...
<h3>Importance</h3> Depression is a common cause of morbidity and disability worldwide. Parental depression associated with early-life child neurodevelopmental, behavioral, emotional, mental, social problems. More studies are needed to explore the link between parental long-term outcomes. <h3>Objective</h3> To examine associations school performance at end compulsory education (approximately age 16 years). <h3>Design, Setting, Participants</h3> diagnoses (based on the<i>International...
Prenatal environmental factors such as maternal adiposity may influence the risk of offspring autism spectrum disorders (ASD), though current evidence is inconsistent. The objective this study was to assess relationship parental BMI and gestational weight gain (GWG) with ASD in a population-based cohort using family-based designs.The based Stockholm County, Sweden, including 333,057 individuals born 1984-2007, whom 6420 were diagnosed an ASD. We evaluated body mass index (BMI) at first...
The possible interaction of serum 25-hydroxyvitamin D [25(OH)D] and obesity in regard to type 2 diabetes insulin resistance has not been well studied. To explore the effect modification on association between 25(OH)D resistance/type diabetes, data were examined from a nationally representative sample.
<h3>Importance</h3> Familial aggregation of mental and neurological disorders is often observed in autism spectrum (ASD), but reports have generally focused on single are limited to first-degree relatives. <h3>Objectives</h3> To examine family history among first- fourth-degree relatives risk ASD with without intellectual disability (ID) index persons. <h3>Design, Setting, Participants</h3> In this population-based cohort study, 567 436 persons were identified from the Stockholm Youth...
<b>Objectives</b> To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring. <b>Design</b> Observational prospective cohort with regression methods, propensity score matching, sibling controls, negative control comparison. <b>Setting</b> Stockholm County, Sweden. <b>Participants</b> 254 610 individuals aged 4-17, including 5378 autism, living Stockholm County 2001-11 who were born to mothers did not...
Animal studies indicate that early life vitamin D is crucial for proper neurodevelopment. Few have examined whether maternal and neonatal concentrations influence risk of autism spectrum disorders (ASD). Participants were sampled from the Stockholm Youth Cohort, a register-based cohort in Sweden. Concentrations total 25-hydroxyvitamin (25OHD) assessed biosamples using highly sensitive liquid chromatography tandem mass spectrometry method. The sample consisted 449 ASD cases 574 controls,...
Abstract The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety other antiseizure medications (ASMs) during remains limited. Using routinely collected primary care data from UK and nationwide Swedish registries to create a cohort 3,182,773 children, which 17,495 were exposed ASMs pregnancy, we show that those more likely receive diagnosis autism, intellectual disability, ADHD, when compared children not ASMs. Additionally,...
Abstract Objective To determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) and without intellectual disability in offspring. Design Observational prospective cohort study using multivariable logistic regression, sibling controls, propensity score matching. Setting Stockholm County, Sweden. Participants 273 107 mother-child pairs identified through population registers. The sample was restricted to children who were...