Objective To examine the relation between childhood adversity, role of school performance, and psychopathology risk suicide.Design Cohort study register based indicators adversity (at ages 0-14) including death in family (suicide analysed separately), parental substance abuse, psychiatric disorder, substantial criminality, separation/single parent household, receipt public assistance, residential instability.Setting Swedish medical birth various population registers.Participants 548 721...

<h2>Summary</h2><h3>Background</h3> Little information exists about the prevalence of children exposed to maternal mental illness. We aimed estimate and adolescents illness in UK between 2005 2017 using primary care data. <h3>Methods</h3> In this national retrospective cohort study, we included aged 0–16 years born Jan 1, 1991, Dec 31, 2015, who were linked their mothers registered on Clinical Practice Research Datalink (CPRD) 2017. extracted data diagnosis, symptoms, therapy from CRPD...

Although many studies indicate the interplay of genetic and environmental factors in etiology autism spectrum disorder (ASD), our limited understanding underlying mechanisms hampers development effective ways detecting preventing disorder. Recent support hypothesis that prenatal androgen exposure contributes to ASD. This would suggest maternal polycystic ovary syndrome (PCOS), a condition associated with excess androgens, increase risk ASD offspring. We conducted matched case–control study...

<h3>Background</h3> Common mental disorders are known to cause long-term disability, although not much is about consequences of milder forms psychological distress. <h3>Objective</h3> To investigate the association between increasing levels distress and 5-year risk disability pensions awarded for somatic or psychiatric conditions. <h3>Methods</h3> In this longitudinal population-based study, a cohort 17 205 individuals, aged 18–64 years, recruited in 2002 Stockholm County was prospectively...

Gender dysphoria (GD) is characterized by incongruence between onés gender assigned at birth and the that one identifies with. The biological mechanisms of GD are unclear, especially in female-to-male transsexuals (FtM-TR). Here, we investigate whether distinct structural functional patterns along cerebral midline networks processing own-body perception may constitute a correlate. Method: MRI connectivity, cortical thickness, surface area, gray matter volume was carried out 28 (FtM-TR) 68...

Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.To clarify the relationship between maternal and offspring ASD with without intellectual disability.Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) 95% confidence intervals (CIs) disability in relation to lifetime diagnoses deficiency. Although rare, such was associated with, not without, (aORs 2.51, CI 1.22-5.16 1.28,...

Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder, and boys are two to three times more likely develop ADHD. Maternal polycystic ovary syndrome (PCOS), a metabolic associated with excess circulating androgens, has been increased risk for autism spectrum in offspring. In this study, we aimed investigate whether maternal PCOS increases ADHD offspring.We conducted matched case-control study using health population data registers all...

Background Though childhood adversity (CA) has been associated with the risk of attention deficit/hyperactivity disorder (ADHD), little is known about effect cumulative CAs and whether there are clusters that more closely related ADHD. Methods We used a Swedish cohort 543 650 individuals born 1987–1991. Register-based included familial death, substantial parental substance abuse psychiatric disorder, criminality, separation, household public assistance recipiency, residential instability....

The number of patients presenting for care at gender clinics is increasing, yet the proportion adults in general population who want gender-affirming medical treatment remains essentially unknown. We measured wish cross-sex hormones or surgery, as well other aspects incongruence, among adult Stockholm County, Sweden. A population-representative sample 50,157 County residents ages 22 and older comprise Public Health Cohort. They were enrolled 2002, 2006, 2010 followed-up roughly 4-year...

Abstract Objective To determine the association between parental mental illness and risk of injuries among offspring. Design Retrospective cohort study. Setting Swedish population based registers. Participants 1 542 000 children born in 1996-2011 linked to 893 334 mothers 873 935 fathers. Exposures Maternal or paternal (non-affective psychosis, affective alcohol drug misuse, mood disorders, anxiety stress related eating personality disorders) identified through linkage inpatient outpatient...

Children of parents with mental illness are a vulnerable group, but their numbers and exposure to adversity have rarely been examined. We examined the prevalence children in Sweden, trends from 2006 2016, these children's socioeconomic adversity.We did population-based cohort study among all (aged <18 years) born Sweden between Jan 1, 1991, Dec 31, 2011, parents, followed up 2006, 2016. included who were identified Total Population Register linked birth excluding adopted those missing...

Background: The 12-item version of the General Health Questionnaire (GHQ-12) is widely used as a proxy for Affective Disorders in public health surveys, although cut-off points distress vary considerably between studies. agreement GHQ-12 score and having clinical disorder study population usually unknown.Aims: This aimed to assess criterion validity determine sensitivity specificity Swedish population.Methods: 556 patient cases surveyed specialized psychiatric care outpatient age-...

Abstract Background Health services utilization for mental health disorders is reported to increase sharply in many countries. The aim of this study was report trends all aspects care a total population sample. Methods Repeated cross-sectional register the Stockholm Region (VAL) including both primary and secondary care. Trends proportion adults with recorded ICD-10 psychiatric diagnosis or psychological therapy during 2007–2017 as well claims medication from 2011 were calculated. Results...

To detail the relationship between parental mental illness and likelihood of out-of-home care (OHC) among their children, to identify factors which modify this relationship.

Background The increasing incidence of mental health problems among young people is a major concern in many Western countries. causal mechanisms underlying these trends are not well established, but factors influenced by current societal changes ought to be implicated. Such include immigration and social adversity as the timing taking on adult roles (e.g. gainful employment, parenthood own housing tenure). We therefore examined relationships between risks psychological distress suicide...

Childhood adversity (CA) is associated with an increased risk of suicide in young adulthood that might be explained by maladaptive trajectories during adolescence. Although adolescent violent offending linked suicide, little known about its role the association between CA and suicide.To examine whether mediates early adulthood.This population-based, longitudinal cohort study a follow-up time spanning 5 to 9 years included 476 103 individuals born Sweden 1984 1988. The population was...

<h3>Importance</h3> Associations between childhood infection, IQ, and adult nonaffective psychosis (NAP) are well established. However, examination of sensitive periods for exposure, effect familial confounding, whether IQ provides a link infection NAP may elucidate pathogenesis further. <h3>Objectives</h3> To test the association with NAP, to find shared confounding explains infection-NAP IQ-NAP associations, examine mediates and/or moderates association. <h3>Design, Setting,...