A5065482383- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Mast cells and histamine
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- IL-33, ST2, and ILC Pathways
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Global Cancer Incidence and Screening
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
Banner - University Medical Center Tucson
2022-2025
Rush University Medical Center
2014-2024
University of Arizona
2023-2024
Banner Health
2023-2024
University of Arizona Cancer Center
2023-2024
RELX Group (Netherlands)
2020-2022
Boston Medical Center
2020
Boston University
2020
Rush University
2011-2018
Cornell University
2013
With the development of reliable endoscopic closure techniques and tools, full-thickness resection (EFTR) is emerging as a therapeutic option for treatment subepithelial tumors epithelial neoplasia with significant fibrosis. EFTR may be categorized "exposed" "nonexposed." In exposed EFTR, undertaken tunneled or nontunneled technique, subsequent defect. nonexposed secure serosa-to-serosa apposition achieved before isolated lesion. This document reviews current devices used clinical...
OBJECTIVES: Bowel preparations (BPs) taken before colonoscopy may introduce a confounding effect on the results of gastrointestinal microbiota studies. This study aimed to determine bowel preparation mucosa-associated and luminal colonic in healthy subjects (HC) inflammatory disease (IBD) patients. METHODS: Biopsy samples (n=36) fecal (n=30) were collected from 10 HC 8 IBD pre- post-BP. 16S rRNA gene was pyrosequenced using 454 Titanium protocols. We compared differences between post-BP...
Objective New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined principles underlying evaluation of new non-invasive in view technological developments and identification biomarkers. Design A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. Results Twelve newly stated emerged. Effectiveness...
In this study, we describe the prevalence of fecal incontinence by race, age, sex, presence major chronic conditions stroke and diabetes, use certain psychoactive medications.Study subjects are participants in Chicago Health Aging Project, a study older residents geographically defined area. period 1993-1996, interviewers conducted door-to-door census that identified 6,099 individuals who participated in-home interviews. The interviews included wide range questions regarding demographics,...
Colorectal cancer (CRC) screening rates are currently suboptimal. Blood-based could improve of earlier detection for CRC and adenomatous colorectal polyps. In this study, we evaluated the feasibility plasma-based early polyps using array-mediated analysis methylation profiling 56 genes implicated in carcinogenesis. Methylation patients with Stages I II (N=30) those were compared individuals who underwent colonoscopy found to have neither changes nor CRC. Composite biomarkers developed CRC,...
Stable blood based miRNA species have allowed for the differentiation of patients with various types cancer. Therefore, specific blood-based might be considered as a methodology which could informative presence cancer potentially from multiple distinct organ sites. Recently, miR-21 has been identified an "oncomir" in tumors while miR-152 tumor suppressor. In this study, we investigated whether circulating and can used early detection lung (LuCa), colorectal carcinoma (CRC), breast (BrCa)...
Artificial intelligence (AI)-based applications have transformed several industries and are widely used in various consumer products services. In medicine, AI is primarily being for image classification natural language processing has great potential to affect image-based specialties such as radiology, pathology, gastroenterology (GE). This document reviews the reported of GE, focusing on endoscopic analysis.The MEDLINE database was searched through May 2020 relevant articles by using key...
Crypt loss is a histological finding in acute gastrointestinal Graft-Versus-Host Disease (GI-GvHD) of undefined clinical significance.Colonic crypt was graded twenty-three patients treated for GI-GvHD following stem cell transplantation and then correlated with parameters disease severity mortality.Crypt present 17/23 cases, 11/23 cases deemed severe by the presence contiguous areas loss. Nine 11 had daily stool volumes excess 1000 ml/day, while only 3/12 those minimal or no this level...
Abstract Purpose: To understand signaling pathways that shape inflamed tissue and predispose to cancer is critical for effective prevention therapy chronic inflammatory diseases. We have explored phosphoinositide 3-kinase (PI3K) activity in human bowel diseases mouse colitis models. Experimental Design: conducted immunostaining of phosphorylated AKT (pAKT) unbiased high-throughput image acquisition quantitative analysis samples noninflamed normal colon, colitis, dysplasia, colorectal cancer....
Adenomatous polyps greater than 1 cm are defined as advanced adenomas. Inaccurate size estimation can lead to inappropriate surveillance recommendations of colorectal adenomas.The aim this study was determine the impact endoscopic polyp mis-sizing on cancer recommendations.This is a prospective study.This conducted in gastroenterology practice at US academic medical center.Patients undergoing screening and colonoscopies from 2010 2011 were included.Endoscopic estimates 10 25 mm compared with...
Adenoma detection rate (ADR) is the accepted marker in colonoscopy quality. Advanced adenomas detected at index colonoscopy, while less frequent than nonadvanced adenomas, carry greater risk for future advanced neoplasia during surveillance colonoscopy. This study aimed to determine effect of colonoscopist and other factors on ADR define correlation ADRs among colonoscopists.An observational a cohort patients undergoing first-time colorectal cancer screening was conducted. Patient...
Abstract Purpose: African Americans (AA) have the highest incidence of colorectal cancer compared with other U.S. populations and more proximal cancers. The objective is to elucidate basis these disparities. Experimental design: Of note, 566 AA 328 non-Hispanic White (NHW) cancers were ascertained in five Chicago hospitals. Clinical exposure data collected. Microsatellite instability (MSI) BRAF (V600E) KRAS mutations tested. Statistical significance categorical variables was tested by Fisher...
Current guidelines for endoscopic surveillance of Barrett’s esophagus (BE) recommend that patients with newly diagnosed BE undergo confirmatory esophagogastroduodenoscopy (EGD) to exclude the presence dysplasia. The extent which endoscopy alters management and detects missed dysplasia in has not been reported. frequency changed was assessed. A two center cohort analysis conducted on BE. rate who had nondysplastic obtained. Demographic variables were assessed association detection using Firth...
Lithotripsy is a procedure for fragmentation or destruction of stones to facilitate their removal passage from the biliary pancreatic ducts. Although most may be removed endoscopically using conventional techniques such as endoscopic sphincterotomy in combination with balloon basket extraction, lithotripsy required clearance large, impacted, irregularly shaped stones. Several modalities have been described, including intracorporeal mechanical (ML), electrohydraulic (EHL), and laser...
Most recurrences of early-stage colorectal cancer detected with current surveillance measures are widespread and incurable. Circulating tumor DNA (ctDNA) may facilitate earlier diagnosis recurrent improve cancer-related outcomes.Plasma from patients undergoing standard after definitive treatment for stage II/III was assayed COLVERA carcinoembryonic antigen (CEA) at a single time point. Results were correlated radiographic imaging. Assay performance, including sensitivity specificity...