Metal nanoshells are a novel type of composite spherical nanoparticle consisting dielectric core covered by thin metallic shell which is typically gold. Nanoshells possess highly favorable optical and chemical properties for biomedical imaging therapeutic applications. By varying the relative dimensions shell, resonance these nanoparticles can be precisely systematically varied over broad region ranging from near-UV to mid-infrared. This range includes near-infrared (NIR) wavelength where...

We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use vivo blood an animal model. Our technique, coherence tomography (CDOCT), performs spatially localized velocimetry by scanning low-coherence interferometry. CDOCT is extension (OCT), employing coherent signal-acquisition electronics joint time-frequency analysis algorithms to perform simultaneous conventional OCT imaging....

Background and Objective A method to increase light transport deeply into target areas of tissue would enhance both therapeutic diagnostic laser applications. The effects a hyperosmotic agent on the scattering properties rat hamster skin were investigated. Study Design/Materials Methods agent, glycerol, was applied in vitro vivo assess changes optical properties. Changes reduced coefficient after application has been rehydrated assessed evaluate effect tissue. Results Experimental results...

The tensile stress-strain behavior of ligaments and tendons begins with a toe region that is believed to result from the straightening crimped collagen fibrils. in situ mechanical function mostly confined this changes crimp morphology are be associated pathological conditions. A relatively new imaging technique, optical coherence tomography (OCT), provides comparatively inexpensive method for nondestructive investigation tissue ultrastructure resolution on order 15 μm potential use clinical...

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.

Doppler optical coherence tomography (DOCT) is a valuable tool for depth-resolved flow measurements in tissue. However, DOCT insensitive to the direction normal imaging beam and requires knowledge of phase demodulated signal. We present an alternative method extracting information, using speckle conventional amplitude images. Due pixel-by-pixel acquisition scheme OCT, time-varying manifested as change OCT image spatial frequencies. tested ability provide quantitative information Intralipid...

Abstract Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin the precancerous condition actinic keratosis (AK). Study Design/Materials Methods OCT images were acquired of 112 patients at 2 protected exposed sites, with subsequent biopsy. Each site received dermatological evaluation, histological diagnosis, solar elastosis (SE) score. examined visually statistically analyzed. Results Characteristic...

We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, OCT. Polyacrylamide-based phantoms appropriate scattering anisotropy coefficients (30 cm−1 0.89, respectively) to image distribution the in an environment similar that tissue. The observed signal was dependent on whether resonance peak overlapped...

We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in 2.0-mm-diameter endoscopic package. OCT provides ∼18-μm resolution cross-sectional structural information over 6-mm field. LIF spectra are collected sequentially at submillimeter across the same field provide histochemical about tissue. present use of rod prism to reduce asymmetry beam caused by cylindrical window. The endoscope has been applied investigate mouse...

In this paper, we propose mmPose-FK, a novel millimeter wave (mmWave) radar-based pose estimation method that employs dynamic forward kinematics (FK) approach to address the challenges posed by low resolution, specularity, and noise artifacts commonly associated with mmWave radars. These issues often result in unstable joint poses vibrate over time, reducing effectiveness of traditional techniques. To overcome these limitations, integrate FK mechanism into deep learning model develop an...

Nanoshell-enhanced optical coherence tomography (OCT) is a novel technique with the potential for molecular imaging and improved disease detection. However, optimization of this approach will require quantitative understanding influence nanoshell parameters on detected OCT signals. In study, was performed at 1310 nm in water turbid tissue-simulating phantoms to which nanoshells were added. The effect concentration, core diameter, shell thickness signal enhancement characterized. Experimental...

A novel laser system has been developed to study the effects of multiple pulses differing wavelengths on cutaneous blood vessels in vivo, using hamster dorsal skin flap preparation and vitro, cuvettes whole or diluted blood. The permits sequenced irradiation with well-defined intrapulse spacing at 532 nm, a long-pulse frequency-doubled Nd:YAG laser, 1064 laser. Using this system, we have identified parameter space where two different act synergistic manner effect permanent vessel damage...

The treatment of cutaneous vascular lesions (port wine stains etc.) using lasers has been guided by theories based on the "cold" or room-temperature optical properties hemoglobin target chromophore. We have recently presented evidence showing that under influence laser irradiation, blood in vitro are time and temperature dependent. Such complications not currently subsumed into vivo theory. Here, we study time-domain undergoing photocoagulation two newly developed time-resolved techniques....

Holographic gratings formed in thick phenanthrenquinone- (PQ-) doped poly(methyl methacrylate) (PMMA) can be made to have narrowband spectral and spatial transmittance filtering properties. We present the design performance of angle-multiplexed holographic filters PQ-PMMA at 488 nm reconstructed with a LED operated ~630 nm. The dark delay time between exposure preillumination polymer prior area are varied optimize diffraction efficiency multiplexed filters. resultant enhance four-dimensional...

Frequency domain optical coherence tomography (FD-OCT) allows interferometer topologies with simplified system construction and handling. Problems of dispersion polarization matching between the sample reference arms, as well beamsplitter spectral non-uniformity, are mitigated when is wholly contained in endoscope tip. A common path set-up, using a reflection originating from inside surface glass envelope at distal end endoscope, an alternative approach more efficient collection light novel...

The generation of biodegradable plasmon resonant nanoparticles may enable their translation to clinical applications. By reducing gold onto the surface liposomes, resonance is generated that tunable by changing density reduced dots. Biodegradation such structures yields clusters size compatible with requirements renal clearance.

We present the design, implementation and performance analysis of a compact multi-photon endoscope based on piezo electric scanning tube. A miniature objective lens with long working distance high numerical aperture (≈ 0.5) is designed to provide diffraction limited spot size. Furthermore, 1700 nm wavelength femtosecond fiber laser used as an excitation source overcome scattering biological tissues reduce water absorption. Therefore, novel optical system along unique allows us increase...

Fall detection, particularly critical for high-risk demographics like the elderly, is a key public health concern, where timely detection can greatly minimize harm. With advancements in radio frequency (RF) technology, radar has emerged as powerful tool human fall detection. Traditional machine learning (ML) algorithms, such support vector machines (SVM) and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -nearest neighbors (kNN), have...

Current dorsal skin flap window chambers with flat glass windows are compatible optical coherence tomography (OCT) and multiphoton microscopy (MPM) imaging. However, light sheet fluorescence (LSFM) performs best a cylindrical or spherical sample located between its two 90° objectives when all materials have the same index of refraction (n). A modified chamber domed viewing made from fluorinated ethylene propylene (FEP), n similar to water tissue, was designed. In vitro imaging collagen gels...

We present the results of first feasibility and safety study a novel multi-modality falloposcope, in 19 volunteers. The falloposcope incorporated multispectral fluorescence imaging (MFI) optical coherence tomography (OCT) for evaluation fallopian tubes (FT). Nineteen females undergoing elective salpingectomy were recruited this IRB-approved study. During 15-min pause standard care surgery, was inserted under hysteroscopic guidance advanced into FTs. furthest cannulated segment (proximal,...

382 Background: Individuals at high risk for gastric cancer may be recommended to undergo risk-reducing gastrectomy, which leads life-long morbidity. Surveillance with endoscopy can an appropriate and effective option avoiding unnecessary surgery. Gastric is commonly characterized by changes in tissue architecture increased stiffness, but visualization of these alterations challenging white light methods. We utilized optical coherence tomography (OCT), a non-destructive imaging modality that...

This study investigates a novel approach for analyzing Sit-to-Stand (STS) movements using millimeterwave (mmWave) radar technology, aiming to develop noncontact, privacy-preserving, and all-day operational solution healthcare applications. A 60GHz mmWave system was employed collect point cloud data from 45 participants performing STS motions. Using deep learning-based pose estimation model Inverse Kinematics (IK), we calculated joint angles, segmented motions, extracted clinically relevant...