A5053237624- Ovarian cancer diagnosis and treatment
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Coronary Interventions and Diagnostics
University of Arizona
2020-2025
BIO5 Institute
2021
Current dorsal skin flap window chambers with flat glass windows are compatible optical coherence tomography (OCT) and multiphoton microscopy (MPM) imaging. However, light sheet fluorescence (LSFM) performs best a cylindrical or spherical sample located between its two 90° objectives when all materials have the same index of refraction (n). A modified chamber domed viewing made from fluorinated ethylene propylene (FEP), n similar to water tissue, was designed. In vitro imaging collagen gels...
Most cases of high-grade serous ovarian carcinoma originate as tubal intraepithelial (STIC) lesions in the fallopian tube epithelium (FTE), enabling early endoscopic detection.
Abstract High‐grade serous carcinoma of the ovary is believed to originate in fallopian tubes (FTs). A submillimeter diameter endoscope with advanced imaging capabilities may take advantage natural pathway female reproductive tract image FTs a minimally invasive procedure for early detection cancer. Our lab previously built prototype benchtop FT pseudowhite light imaging, multispectral fluorescence and optical coherence tomography. This was approximately 0.9 mm diameter, flexible steerable...
We present the design and feasibility testing of a multimodal co-registered endoscope based on dual-path optical system integrated with scanning piezo. This incorporates three different imaging modalities. A large field view reflectance enables visualization objects several millimeters in front endoscope, while coherence microscopy multiphoton are employed contact tissue to further analyze suspicious areas. The allows multiple modalities by employing dual path. One path features low...
Multimodal imaging is an advantageous method to increase the accuracy of disease classification. As example, we and others have shown that optical coherence tomography images fluorescence spectroscopy contain complementary information can sensitivity specificity for cancer detection. A common challenge in multimodal image co-registration. The different are often taken with separate setups, making it challenging precisely same tissue area or co-register computationally. To solve this problem,...
Ovarian cancer is the deadliest gynecological cancer, with most cases of high-grade serous ovarian carcinoma originating as tubal intraepithelial (STIC) lesions in fallopian tube epithelium. The Cell-Acquiring Fallopian Endoscope (CAFE) was designed to optically detect these STIC and collect cells from suspicious site for further analysis. While approximately 0.93 mm diameter, CAFE able perform multispectral fluorescence imaging (MFI), white light navigation, cell collection. Each modalities...
We present engineering design improvements upon a prototype fallopian tube endoscope. These modifications allow for interchangeability between endoscopes and reduce complexity. The construction time each endoscope has been significantly reduced compared to the prototype.