A software and a hardware system for artificial smell detection is described. It has been designed implemented on local CPU to detect follow gradients of odor concentration. based inorganic semiconductor sensors, but the method also useful organic sensors. When mounted an autonomous platform it used as guide robotic navigation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Traditional imaging with one-photon confocal microscopy and organic fluorophores poses several challenges for the visualization of vascular tissue, including autofluorescence, fluorophore crosstalk, photobleaching. We studied human coronary arteries (HCAs) mouse aortas a modified immunohistochemical (IHC) “en face” method using quantum dot (Qdot) bioconjugates two-photon excitation laser scanning (TPELSM). demonstrated feasibility multilabeling intimal structures by exciting multicolored...

We present the design and feasibility testing of a multimodal co-registered endoscope based on dual-path optical system integrated with scanning piezo. This incorporates three different imaging modalities. A large field view reflectance enables visualization objects several millimeters in front endoscope, while coherence microscopy multiphoton are employed contact tissue to further analyze suspicious areas. The allows multiple modalities by employing dual path. One path features low...

Multimodal imaging is an advantageous method to increase the accuracy of disease classification. As example, we and others have shown that optical coherence tomography images fluorescence spectroscopy contain complementary information can sensitivity specificity for cancer detection. A common challenge in multimodal image co-registration. The different are often taken with separate setups, making it challenging precisely same tissue area or co-register computationally. To solve this problem,...

Early detection of cancer is crucial for improving patient survival. High resolution optical imaging ideal to image cellular abnormalities indicative early cancer. For tissues located deep within the body, such as pancreato-biliary ducts, high must be implemented endoscopically due limited penetration depth light. We are developing a minimally invasive numerical aperture (HNA) microendoscope system capable simultaneous co-registered multiphoton (two-photon excited fluorescence, second...

We demonstrate the use of patterned dichroic surfaces with reflective optical power to create multiple paths in a single lens system. The application these enables micro-endoscope accommodate imaging technologies only one system, making packaging more compact and reliable. are spectrally separated using different wavelengths for each path. designed such that visible transmit through optically unaffected, but near-infrared reflected telescope-like configuration curved providing power....

Abstract Piezoelectric tube actuators with cantilevered optical fibers have enabled the miniaturization of scanning image acquisition techniques for endoscopic implementation. To achieve raster such a miniaturized system, first resonant frequency should be order 10 s Hz. We explore adding mass at an intermediate location along length fiber to alter frequencies system. provide mathematical model predict beam mass. The theoretical and measured data match well various lengths, sizes, attachment...

While Optical Coherence Microscopy (OCM), Multiphoton (MPM), and narrowband imaging are powerful techniques that can be used to detect cancer, each technique has limitations when by itself. Combining them into an endoscope work in synergy help achieve high sensitivity specificity for diagnosis at the point of care. Such complex endoscopes have elevated risk failure, performing proper modelling ensures functionality minimizes risk. We present full 2D 3D models a multimodality optical...

This poster describes a new end-to-end virtual prototype solution we have developed for simulating the performances of whole system CMOS Image Sensor Camera from imaging lens to final image, through optoelectronic sensor itself. Finite Difference Time Domain (FDTD) software is used simulate how much light absorbed by structure and diffraction effects throughout micro-lenses pixels. 3D Charge Transport Solver compute probability capture photogenerated charge get quantum efficiency as function...

The merit function defines the permissible range of component variable values in optimizing lens systems. This ensures optimization algorithm explores parameter variations within specified bounds, contributing to generation feasible designs. In this study, we introduce an approach identify optimization-sensitive surface parameters a relay through utilization multi-configuration composite feature. sensitivity is analyzed by employing Zernike Standard Sag Surface as add-on surface, with...

CMOS image sensor cameras are widely used in various applications, across industries such as aerospace and defense, automotive, consumer electronics. With the emergence of high-resolution cameras, obtaining best quality is becoming a must-have requirement. There growing need to design optimize each camera component considering full system targeted application environment. Accurate modeling components can be challenging due multiscale structures going from nanoscale photonics macroscale...

Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize proper design, optomechanical analysis modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed perform Optical Coherence Multiphoton Microscopy (OCM MPM) are powerful endoscopic imaging techniques used characterize tissue. Separately each technique has limitations when by...

Multimodal endoscopes are highly complex and difficult to miniaturize, thus packing multiple optical systems into them requires ingenuity, creativity a special set of design optomechanical skills. While multimodal miniaturized endoscope becoming hot topic nowadays, few designs have been explained in enough detail for the scientific community utilize this knowledge. We present our approach manufacturing an endoscopic prototype that encapsulates Optical Coherence Microscopy (OCM), Multi Photon...

We rapidly designed, 3D printed, and tested a singlet lens with an outer diameter of 0.5mm extended depth focus, for endoscopic applications. Practical considerations comparison to commercially-available microlenses are provided.

Multimodal probes with microscopy capabilities can obtain high-resolution images of tissue without additional probes. Initial results modeling and evaluation the optical performance predict possible feasibility multimodal system.

Recent discoveries suggest that ovarian cancer has its origins in the oviducts (Fallopian tubes) and may exist as intraepithelial carcinoma for up to 6 years.One route of access ovaries is through wall vagina.We have developed an approximately 3.8 mm diameter rigid salpingoscope surveillance high-risk women early detection cancer.The contains multiple advanced imaging modalities, well a channel instillation saline or dyes, another introduction biopsy forceps.The single optical combines...

Propagation of broadband, ultrashort pulses through a few meters standard silica fiber can severely distort and broaden the pulse due to dispersion nonlinearity. Choice compensation reduce these effects.

Questions about the feasibility and risks of complex optical systems can be answered by ray-trace models evaluating system performance. A problem is that these simulations require hours for each run, months a complete result. solution to automate analysis using programming language, but there remains challenge creating engine perform analysis. We instead utilize Application Programming Interface (API) existing engines many customized analyses. As an example, we computed SNR map as function...