A5019670095- Renal Transplantation Outcomes and Treatments
- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Spondyloarthritis Studies and Treatments
- Health disparities and outcomes
- Adolescent Sexual and Reproductive Health
- Rheumatoid Arthritis Research and Therapies
- Occupational and environmental lung diseases
- HIV/AIDS Impact and Responses
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- HIV, Drug Use, Sexual Risk
- Air Quality and Health Impacts
- Palliative Care and End-of-Life Issues
- Organ Donation and Transplantation
- Gene expression and cancer classification
- Renal Diseases and Glomerulopathies
- Child Nutrition and Water Access
- Hip and Femur Fractures
- Arsenic contamination and mitigation
- Maternal Mental Health During Pregnancy and Postpartum
- Religion, Spirituality, and Psychology
University of Alberta
2016-2025
Alberta Bone and Joint Health Institute
2021
Kansas State University
2011
Faculty of Public Health
2008-2010
Provincial Laboratory of Public Health
2006-2009
University of Illinois Chicago
2009
Rakai Health Sciences Program
2007
University of Alberta Hospital
2001-2006
West Virginia University
2006
Alberta Hospital Edmonton
2001-2006
<h3>Background</h3> The clinical and epidemiological relevance of different prognostic factors for survival in patients with advanced or terminal cancer remains controversial. <h3>Purposes</h3> To establish the after diagnosis disease to determine predictors survival. <h3>Methods</h3> An inception cohort 227 consecutive aged 18 years older lung, breast, gastrointestinal tract were observed from July 1, 1996, through December 31, 1998. Tumor- treatment-specific, clinical, laboratory,...
Gene-set analysis evaluates the expression of biological pathways, or a priori defined gene sets, rather than that individual genes, in association with binary phenotype, and is great biologic interest many DNA microarray studies. Gene Set Enrichment Analysis (GSEA) has been applied widely as tool for gene-set analyses. We describe here some critical problems GSEA propose an alternative method by extending individual-gene method, Significance Microarray (SAM), to analyses (SAM-GS).Using...
Herpes zoster (HZ) infection is a frequent and serious complication of organ transplantation that has not been examined in the current era immunosuppression.All solid transplants performed between 1994 1999 (n = 869) at our center were analyzed to determine incidence, complications risk factors for developing HZ.The overall incidence HZ was 8.6% (liver 5.7%, renal 7.4%, lung 15.1% heart 16.8%). The median time onset 9.0 months. We observed high rates cutaneous scarring (18.7%) post-herpetic...
To determine the safety and efficacy of intravenous (IV) pamidronate treatment in ankylosing spondylitis (AS) patients who have had a suboptimal response to nonsteroidal antiinflammatory drugs (NSAIDs).Pamidronate at 60 mg was compared with 10 rather than placebo view high incidence transient arthralgias upon first IV exposure drug. The drug were given monthly for 6 months randomized double-blind, controlled trial. inclusion criterion active disease (Bath AS Disease Activity Index [BASDAI] >...
Microarrays offer potential for objective diagnosis and insights into pathogenesis of allograft rejection. We used mouse transplants to annotate pathogenesis-based transcript sets (PBTs) that reflect major biologic events in rejection—cytotoxic T-cell infiltration, interferon-γ effects parenchymal deterioration. examined the relationship between PBT expression, histopathologic lesions clinical diagnoses 143 consecutive human kidney transplant biopsies cause. PBTs correlated strongly with one...
We studied the significance of microcirculation inflammation in kidney transplants, including 329 indication biopsies from 251 renal allograft recipients, who were mostly nonpresensitized (crossmatch negative). Glomerulitis (g) and peritubular capillaritis (ptc) often associated with antibody-mediated rejection (65% 75%, respectively), but also found other diseases absence donor-specific antibody (DSA): T-cell-mediated (ptc, g), glomerulonephritis acute tubular necrosis (ptc). To develop...
Background. Health-related quality of life (HRQL) is an important outcome in the treatment end-stage renal disease (ESRD) and appears to be highly associated with patient self-report symptom burden. This study examines longitudinal validity modified Edmonton assessment system (ESAS) determine impact change burden on HRQL haemodialysis (HD) patients. Methods. 261 patients completed Kidney Disease Quality Life-Short Form (KDQOL-SF) ESAS at baseline 6 months. Results. The overall distress score...
The objective of this cross-sectional study was to assess the use traditional herbal medicine by AIDS patients in Kabarole District, western Uganda. Using systematic sampling, 137 were selected from outpatient departments 3 hospitals and interviewed via questionnaire. questions related such areas as type frequency intake, concomitant herb-pharmaceutical drug (including herb-antiretroviral cotherapy), perceived effectiveness medicine. Overall, 63.5% had used after HIV diagnosis. Same-day...
Emerging molecular analysis can be used as an objective and independent assessment of histopathological scoring systems. We compared the existing Banff i-score to total inflammation (total i-) score for assessing phenotype in 129 renal allograft biopsies cause. The showed stronger correlations with microarray-based gene sets representing major biological processes during rejection. Receiver operating characteristic curves that total-i was superior (areas under 0.85 vs. 0.73 i-score, p =...
Abstract Objective To determine the efficacy of fluoroscopically guided corticosteroid injection for hip osteoarthritis (OA) in a randomized, double‐blind, placebo‐controlled trial. Methods Fifty‐two patients with symptomatic OA were randomly allocated to receive placebo (10 mg bipuvicaine, 2 ml saline) (n = 21) or treatment 40 triamcinolone hexacetonide) 31). Patients followed up 1, 2, 3, and 6 months. The primary outcome measure was pain improvement response, defined as 20% decrease...
Abstract. The function of renal transplants can deteriorate at any time posttransplant, but the risks and mechanisms may differ different times posttransplant. Survival 522 consecutive cadaveric transplant recipients followed for least 6 mo were analyzed, with patient death censored. overall risk factors in univariate analysis acute rejection requiring antibody therapy (AR), delayed graft function, elevated serum creatinine mo, high panel-reactive antibodies, donor age ≥55 yr, borderline...
Nephrologists commonly engage in end-of-life decision-making with patients ESRD and their families. The purpose of this study was to determine the perceived preparedness nephrologists make decisions factors that are associated highest level preparedness. nephrologist members Renal Physicians Association (RPA) Canadian Society Nephrology were invited participate an online survey practices. A total 39% 360 respondents themselves as very well prepared decisions. Age >46 yr, six or more...
Expression of the transcription factor forkhead box P3 (FOXP3) in transplant biopsies is interest due to its role a population regulatory T cells. We analyzed FOXP3 mRNA expression using RT-PCR 83 renal for cause relationship histopathology, clinical findings and pathogenesis-based transcript sets assessed by microarrays. was higher rejection (T-cell antibody-mediated) than nonrejection. Surprisingly, some native kidney controls also expressed mRNA. Immunostaining consistent with RT-PCR,...
To examine a population-based cohort for the association between clinicopathologic predictors of survival and immunohistochemical markers (IHC), to assess changes in gene expression that are associated with lymphovascular invasion (LVI).LVI has been poor aggressive tumor behavior. The molecular responsible behavior gastric cancer have yet be determined. Characterization IHC profiles may identify alterations governing behavior.: Clinicopathologic data 114 patients were reviewed. Archival...
While glomerulitis is graded according to the Banff classification, no criteria for scoring peritubular capillaritis (PTC) have been established. We retrospectively applied PTC-scoring 688 renal allograft (46 preimplantation, 461 protocol, 181 indication) biopsies.A total of 26.3% all analyzed biopsies had (implant 0%, protocol 17.6%, indication 45.5%; p < 0.0001). The most common pattern was moderate severity (5–10 luminal cells), focal in extent (10–50% PTC), with a minority neutrophils. A...