A5086064363- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Microbial Metabolites in Food Biotechnology
- Diverse academic and cultural studies
- Pharmacological Effects of Natural Compounds
- Esophageal and GI Pathology
- Phytochemistry and Bioactive Compounds
- Infection Control and Ventilation
- Skin Protection and Aging
- Neuroendocrine Tumor Research Advances
- Vitamin C and Antioxidants Research
- Cardiovascular Function and Risk Factors
- Essential Oils and Antimicrobial Activity
- Respiratory and Cough-Related Research
- Pomegranate: compositions and health benefits
- Cardiovascular Health and Disease Prevention
- Mycobacterium research and diagnosis
University of Bologna
2015-2024
Azienda USL di Bologna
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Istituto delle Scienze Neurologiche di Bologna
2023-2024
Policlinico S.Orsola-Malpighi
2023
Seattle University
2014
Virginia Mason Medical Center
2014
Direction de la Recherche Technologique
2001
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2000
The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice aligned with standards of care.International multicentre prospective non-interventional registry starting in 2013 aimed evaluate the decisions and outcomes H. by European gastroenterologists. Patients were registered an e-CRF AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events outcomes. Data monitoring was...
INTRODUCTION: Antibiotic resistance is one of the main factors that determine efficacy treatments to eradicate Helicobacter pylori infection. Our aim was evaluate effectiveness first-line and rescue against H. in Europe according antibiotics resistance. METHODS: Prospective, multicenter, international registry on management (European Registry Management). All infected culture-diagnosed adult patients registered Spanish Association Gastroenterology-Research Electronic Data Capture from 2013...
Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends reduce impact effectiveness of various treatments. Objective: To conduct a time-trend analysis Helicobacter pylori antibiotics in Europe. Methods: The international prospective European Registry Management (Hp-EuReg) collected data all infected adult patients diagnosed with culture and antimicrobial testing positive results that were...
Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate efficacy.
ABSTRACT Clarithromycin-based regimens are commonly used as a first-line therapy for Helicobacter pylori -positive patients; however, resistance to clarithromycin has led treatment failures. The aim of this study was evaluate the feasibility using stool samples detect presence H. DNA while concurrently detecting mutations associated with clarithromycin. For purpose, total extracted from 294 raw specimens and -negative patients. TaqMan real-time PCR amplification well predict phenotype...
The increasing prevalence of strains resistant to antimicrobial agents is a critical issue in the management Helicobacter pylori (H. pylori) infection.(1) To evaluate primary resistance clarithromycin, metronidazole and levofloxacin (2) assess effectiveness sequential therapy on (3) identify minimum number subjects enrol for evaluating an eradication regimen patients harbouring strains.Consecutive 1682 treatment naïve H. pylori-positive referred upper GI endoscopy between 2010 2015 were...
Helicobacter pylori treatment still remains a challenge for physicians, and no current first-line therapies are able to cure the infection in all treated patients. Two very large meta-analysis studies showed that standard 7—14 days triple fail eradicate H. up 20—25% of patients [Fuccio et al. 2007; Zullo 2007]. In addition, efficacy these regimens is even decreasing worldwide. Indeed, during last few years, different have found success rate following such disappointingly low, with values...
Primary clarithromycin resistance is the main factor affecting efficacy of Helicobacter pylori therapy. This study aimed: (i) to assess concordance between phenotypic (culture) and genotypic (real-time PCR) tests in resistant strains; (ii) search, case disagreement methods, for point mutations other than those reported as most frequent Europe; (iii) compare MICs associated with single mutations. In order perform real-time PCR, we retrieved biopsies from patients whom H. infection was...
Background and aims: the increasing prevalence of strains resistant to antimicrobial agents is a critical issue for management Helicobacter pylori infection. This study aimed evaluate, in Italian naïve patients, H. antibiotic resistance trends their potential predictive factors during last decade. Methods: consecutive positive referred from General Practitioners our Unit January 2009 2019 perform an upper gastrointestinal endoscopy (UGIE), were considered. Each patient underwent 13C-urea...
Italian guideline suggests 10-day sequential or bismuth-based quadruple therapies for first-line Helicobacter pylori treatment. Comparison between these regimens is lacking. We assessed the efficacy of in clinical practice and evaluated role primary bacterial resistance toward clarithromycin metronidazole.Consecutive patients with H. infection were enrolled. Bacterial culture antibiotics susceptibility testing was attempted all cases. Patients received either a therapy esomeprazole 40 mg 10...
Introduction: Eradicating Helicobacter pylori continues to be a challenge, and no treatment regimen is uniformly successful in all treated patients. Triple therapy with rifabutin amoxicillin rescue after consecutive failures. We designed this study test the efficacy of 12-day rifabutin-based triple patients infected multidrug-resistant strains. Methods: Consecutive dyspeptic symptoms at least 1 antibiotic course for H. infection harboring triple-resistant (clarithromycin, metronidazole,...
Treatment of Helicobacter pylori (H. pylori) infection is a challenge for clinicians. The large increase in drug-resistant strains makes the formulation new therapeutic strategies fundamental. frequent onset side effects during antibiotic treatment (mainly due to intestinal dysbiosis) should not be underestimated as it may cause interruption treatment, failure H. eradication and clonal selection resistant bacteria. Probiotic integration can exert dual function: direct antagonistic effect on...
First-line
Rapid diagnostic tools for Helicobacter pylori are important in endoscopy.To assess the accuracy of a new 5 min rapid urease test (UFT300, ABS Srl, Cernusco sul Naviglio, Milan, Italy) and to compare it with 1 h Pyloritek (Serim Laboratories, Elkhart, IN, USA) 24 CLO (Kimberly-Clark Ballard Medical Products, Roswell, GA, USA).Consecutive dyspeptic patients referred our unit endoscopy were prospectively studied. All underwent (13)C-urea-breath test, histology UFT300 (ABS Srl; Italy). In...
Antimicrobial resistance to clarithromycin and metronidazole significantly affects the cure rate of standard therapies for Helicobacter pylori infection. We tested whether different MIC levels these antibiotics play a role in therapeutic efficacy.This was post hoc analysis data from trial which patients with antibiotic susceptibility testing (Etest) received first-line sequential therapy. The level classified according values into low (MIC >0.5 ≤8 clarithromycin, >8 ≤32 metronidazole) high...
The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact outcomes H. treatment. aim study was to evaluate diagnostics and effectiveness eradication between younger European populations. "European Registry on Management (Hp-EuReg)" data from 2013 2022 were analyzed. Patients divided into (≥ 60 years) (18-59 groups. Modified intention-to-treat (mITT) per-protocol (PP) analysis performed. 49,461 patients included which 14,467...
Purpose: Bacterial resistance toward the most used antibiotics is increasing in Helicobacter pylori strains worldwide. Emergence of multidrug significantly affects efficacy standard therapy regimens. Therefore, monitoring for primary antimicrobial essential H. management clinical practice.Methodology: isolates obtained from patients consecutively observed a single center were tested by using E-test method. showing MIC values >0.5, >8 and >1 mg/L clarithromycin, metronidazole levofloxacin,...
Helicobacter pylori (H. pylori) eradication fails in a definite amount of patients despite one or more therapeutic attempts. Curing these is progressively difficult, due to development antibiotic resistance. Current guidelines suggest testing susceptibility H. isolates following two attempts.to evaluate the resistance, MIC values trends and outcomes who failed at least therapy.consecutive patients, referred perform upper gastrointestinal endoscopy (UGIE) our Unit from January 2009 2019...