A5063070755- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Gastroesophageal reflux and treatments
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Celiac Disease Research and Management
- Gastric Cancer Management and Outcomes
- Microbial Metabolites in Food Biotechnology
- Galectins and Cancer Biology
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Urinary Tract Infections Management
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Enterobacteriaceae and Cronobacter Research
- Antimicrobial Resistance in Staphylococcus
- Microscopic Colitis
- Reproductive tract infections research
- Essential Oils and Antimicrobial Activity
- Gastrointestinal motility and disorders
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
Medical University of Sofia
2016-2025
National Center of Infectious and Parasitic Diseases
2024
Czech Academy of Sciences, Institute of Microbiology
2020
University Hospital St. Ivan Rilski
2003-2005
Hôpital Saint-André
1991
Hôpital des Enfants
1991
The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice aligned with standards of care.International multicentre prospective non-interventional registry starting in 2013 aimed evaluate the decisions and outcomes H. by European gastroenterologists. Patients were registered an e-CRF AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events outcomes. Data monitoring was...
INTRODUCTION: Antibiotic resistance is one of the main factors that determine efficacy treatments to eradicate Helicobacter pylori infection. Our aim was evaluate effectiveness first-line and rescue against H. in Europe according antibiotics resistance. METHODS: Prospective, multicenter, international registry on management (European Registry Management). All infected culture-diagnosed adult patients registered Spanish Association Gastroenterology-Research Electronic Data Capture from 2013...
Propolis exhibits antimicrobial, anti-inflammatory and other biological effects. The aim of this study was to evaluate the activity 30 % ethanolic extract Bulgarian propolis against 94 Helicobacter pylori strains by three methods. By agar-well diffusion method, only 13.8 exhibited no inhibition μl (containing 9 mg propolis) all isolates were inhibited some extent 90 (27 per well. mean diameters growth 30, 60 or 96 ethanol well 16.8, 19.2, 27.5 8.3 mm, respectively. more active than ( P <...
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe sometimes fatal pseudomembranous colitis. are associated with disruption gut microbiota caused by antimicrobial agents. predominantly hospital-acquired, but in last decades, CDI patterns have changed. Their prevalence increased, proportion community-acquired CDIs has also...
Antibiotic resistance in Helicobacter pylori is the major cause of eradication failure. Primary H. susceptibility patterns, however, are becoming less predictable. Currently, high (≥20%) clarithromycin rates have been observed USA and developed countries Europe Asia, while highest (≥80%) metronidazole-resistance reported Africa, Asia South America. quinolone-resistance 10% or more already Asia. amoxicillin has low (0 to <2%) but higher (6–59%) Similarly, tetracycline absent (<5%) most...
Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate efficacy.
The aim of the study was to detect anti‐Helicobacter pylori activity seven Lactobacillus delbrueckii subsp. bulgaricus (GLB) strains by four cell‐free supernatant (CFS) types. Activity non‐neutralized and non‐heat‐treated (CFSs1), heat‐treated (CFSs2), pH neutralized, catalase‐treated (CFSs3), or catalase‐ (CFSs4) CFSs against 18 H. (11 which with antibiotic resistance) evaluated. All GLB produced bacteriocin‐like inhibitory substances (BLISs), neutralized two inhibited >81% test those were...
Aim: To evaluate the prescriptions patterns, effectiveness, and safety of adding probiotics to Helicobacter pylori eradication therapy, in Europe. Design: International, prospective, non-interventional registry clinical practice European gastroenterologists. Data were collected quality reviewed until March 2021 at AEG-REDCap. The effectiveness was evaluated by modified intention-to-treat analysis, differentiating geographic areas. Adverse events (AE) categorized as mild, moderate, severe....
The aim of this study was to evaluate the presence and prevalence multidrug antibacterial resistance in Helicobacter pylori Bulgaria from 2005 2008. 828 untreated adults, 124 treated adults 105 children was, respectively, 26.5, 50.8 16.2% for metronidazole; 18.4, 45.2 19% clarithromycin; 1, 2.4 0% amoxicillin; 4.4, 10.6 1.9% tetracycline; 9, 14.5 5.8% ciprofloxacin. Triple evaluated agents uncommon detected 1% children, 3.5% 13.6% adults. Five H. strains were resistant amoxicillin,...
A total of 36 consecutive clinical and two fecal-screening carbapenem-resistant Klebsiella pneumoniae isolates from Bulgarian university hospitals (Varna Pleven) were investigated. Susceptibility testing, conjugation experiments, plasmid replicon typing carried out. Beta-lactamases characterized by isoelectric focusing, PCR, sequencing. Clonal relatedness was investigated RAPD multilocus sequence (MLST). Most the demonstrated multidrug resistance profile. Amikacin tigecycline retained good...
The treatment of Helicobacter pylori with antimicrobial agents has largely been ineffective, and susceptibility results are in disagreement those obtained by standard vitro testing. bactericidal effect amoxicillin was tested an model using sessile bacteria attached to HEp-2 cells; this compared that against planktonic bacteria. Viable cell counts were performed procedures after 1, 6, 24 h contact the antibiotic at different concentrations. A (99.9% killing) observed concentrations only 10,...