A5054352996- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Organic Electronics and Photovoltaics
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Thin-Film Transistor Technologies
- Bacterial biofilms and quorum sensing
- Endodontics and Root Canal Treatments
- Clostridium difficile and Clostridium perfringens research
- Reproductive tract infections research
- Gut microbiota and health
- Conducting polymers and applications
- Laser Applications in Dentistry and Medicine
- Photodynamic Therapy Research Studies
- Silicon and Solar Cell Technologies
- Infective Endocarditis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Syphilis Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal and Maternal Infections
- Ear Surgery and Otitis Media
- Otolaryngology and Infectious Diseases
Medical University of Sofia
2015-2025
Czech Academy of Sciences, Institute of Microbiology
2024
Bulgarian Academy of Sciences
2016-2023
Institute of Biodiversity and Ecosystem Research
2023
University of Forestry
2023
Central Laboratory of Solar Energy and New Energy Sources
2016-2022
Medical University Plovdiv
2022
Medical University of Varna
2022
Faculty of Public Health
2022
Plovdiv University
2022
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe sometimes fatal pseudomembranous colitis. are associated with disruption gut microbiota caused by antimicrobial agents. predominantly hospital-acquired, but in last decades, CDI patterns have changed. Their prevalence increased, proportion community-acquired CDIs has also...
Lactococcosis caused by Lactococcus garvieae is a bacterial infection affecting fish with considerable economic impact. Recently, L. has established itself as an opportunistic pathogen in humans. The aim of the current study was to test classical and molecular-biological methods for identification examine antimicrobial susceptibility capsule production, important virulence factor. Additionally, tests differentiation from closely related species, well epidemiological typing, were performed....
Facial paralysis is an infrequent and serious potential complication of acute otitis media (AOM). We describe a pediatric case rapidly progressive facial as secondary alongside AOM, caused by the non-typeable Haemophilus influenzae (NTHi) strain, which was managed with nerve decompression, glucocorticoid medication, antimicrobial chemotherapy. The reasons why NTHi becomes pathogenic in certain patients are not yet fully understood, specific interactions adaptations that lead to complications...
The aim of the present study was to evaluate bactericidal effects different disinfection methods against microbial biofilms grown in root canals.A total 300 freshly-extracted human teeth were infected with pathogens. biofilm formation and laser therapy, photodynamic therapy (PDT), iontophoresis, irrigating solutions evaluated by counting generations cells samples canals scanning electron microscopy.Enterococcus faecalis other Gram-positive cocci demonstrated highest sensitivity antibacterial...
The SARS-CoV-2 pandemic demonstrated the importance of proper understanding epidemiology viral infections in modern cosmopolitan world. In this retrospective study, we analyzed different factors associated with spread Sandanski municipality, a small and isolated region Bulgaria, classical continental Mediterranean climate. We collected 418 serum samples from people without symptoms infection or other respiratory diseases. were tested for COVID-19 markers qualitative quantitative ELISA anti-N...
The aim of this study was to verify whether the human DR-ELISA for detection anti-SARS-CoV-2 antibodies can be applied in cats, and assess risk factors that determine spread virus among cat population Bulgaria. included 92 serum samples collected from 68 domestic 24 stray cats aged 3 months 20 years age period January–June 2021. originated three regions Bulgaria places inhabitance. based on peroxidase-labeled SARS-CoV-2 N protein employed detect IgA, IgG IgM samples. Subsequently, results...
Chronic rhinosinusitis (CRS) is a condition affecting as much 16% of the adult population in developed countries with many factors attributed to its development, including more recently proposed role bacterial biofilm infections. Plenty research has been conducted on biofilms CRS and causes behind development such an infection nasal cavity sinuses. One probable cause production mucin glycoproteins by mucosa cavity. To investigate possible link between formation expression levels their...
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women reproductive age. The purpose this study was to determine frequency BV Bulgarian pregnant and nonpregnant from several age ranges compare three different laboratory methods for Gardnerella vaginalis detection patents suffering BV.Between September 2011 June 2012, 809 16-40 years separated two major groups: - 469 (355 with 114 without symptoms) 340 (213 127 respectively) were enrolled study. underwent tests...
Across the globe, upper respiratory tract infections (URTIs) are most prevalent cause of morbidity in childhood.The aim our study is to analyze incidence and etiology bacterial URTIs Bulgarian children, as well increasing antimicrobial resistance common etiologic agents over a period 17 years.Retrospective study.The material comprised data from 4768 patients (aged 1-16 years) with URTI during 1998-2014. Specific microbiology agent detection was performed by culture examination....
Prevalence of antibiotic resistant Helicobacter pylori was compared between 50 patients living outside the capital city and matched pairs residents (CCRs). H. isolates from 2018 to 2022 were included. Resistance rates in CCRs those elsewhere 4.0 6.0% amoxicillin, 48.0 42.0% metronidazole, 30 30% clarithromycin, 4.0% tetracycline, respectively. Levofloxacin resistance higher (38.0%) vs 20.0% (P = 0.047) country. Odd ratio for levofloxacin pair-matched groups 2.45 (95% CI, OR 1.0-6.02, P value...
Moraxella catarrhalis has been recognized as an important cause of upper respiratory tract and middle ear infections in children, well chronic obstructive pulmonary disease bronchitis adults. We aim to study the clonal structure, antimicrobial resistance, serotypes M. strains recovered from patients different ages. Nasopharyngeal swabs, fluid, sputum samples were collected. In vitro susceptibility testing was performed according EUCAST criteria. The monoclonal Ab hybridoma technique used for...
The study presents the PDT with metal phthalocyanines on biofilms grown in root canals of ten representatives Gram-positive and Gram-negative bacterial species a fungus Candida albicans which cause aqute teeth infections canals.. extracted human single-root infected for 48 h microorganisms conditions to form above pathogens were treated. stage biofilm formation effect samples determined by scaning electron microscopy standard microbial tests. treating procedure included 10 min incubation...
Group A streptococcus (GAS) is a human pathogen causing broad range of infections, linked with global morbidity and mortality. Macrolide resistance rates vary significantly in different parts the world. Driving factors emergence spread resistant clones are not clearly understood. We investigated 102 macrolide-resistant GAS strains collected during period 2014-2018 from various clinical specimens Bulgarian patients. Strains were characterized by presence mefA/mefE, ermA, ermB using polymerase...