A5068344711- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- Hepatitis Viruses Studies and Epidemiology
- Esophageal and GI Pathology
- Antifungal resistance and susceptibility
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Abdominal vascular conditions and treatments
- Alcohol Consumption and Health Effects
- Gastrointestinal Tumor Research and Treatment
- Veterinary medicine and infectious diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hospital Universitario Infanta Leonor
2009-2025
Hospital de Clínicas
2025
Centro Uruguayo de Imagenología Molecular
2025
Universidad de la República
2025
Hospital General de La Rioja
2017-2024
Hospital Universitario Sanitas La Moraleja
2019-2024
Universidad Francisco de Vitoria
2024
Instituto Nacional del Cáncer
2022
Ministerio de Salud Pública y Bienestar Social
2022
Instituto de Salud Carlos III
2021
Abstract Measurements of portal pressure, usually obtained via the hepatic venous pressure gradient (HVPG) may be a prognostic marker in cirrhosis. The aim this study was to evaluate impact HVPG on survival patients with cirrhosis addition Model for End-Stage Liver Disease (MELD) score. We also examined whether inclusion model MELD variables improves its ability. Retrospective analyses all who had measurements between January 1998 and December 2002 were considered. Proportional hazards Cox...
BACKGROUNDS Antiviral therapy (AVT) may improve liver histology in patients with advanced viral hepatitis but its effect on portal pressure remains unknown. AIM This study was aimed to evaluate the influence of antiviral hepatic venous gradient (HVPG) C virus infected hypertension. METHODS Twenty compensated chronic C, fibrosis stage 3 or 4 and HVPG > 5 mmHg received PEG-IFN α2b plus ribavirin. Every patient underwent biopsy measurements before immediately after AT. Biopsies were evaluated...
Insulin resistance affects sustained virological response (SVR) in chronic hepatitis C. To know whether adding metformin to standard antiviral treatment improves SVR, we conducted a prospective, multicentered, randomized, double-blinded, placebo-controlled trial 19 Spanish hospitals, including 123 consecutive patients with genotype 1 C and insulin resistance. Patients were randomized receive either (arm A; n = 59) or placebo B; 64) addition peginterferon alfa-2a (180 microg/week) ribavirin...
Background We hypothesized that the addition of sirolimus to standard horse antithymocyte globulin (h-ATG) and cyclosporine (CsA) would improve response rates in severe aplastic anemia, due its complementary synergistic properties A.Design Methods To test this hypothesis, we conducted a prospective randomized study comparing hATG/CsA/sirolimus h-ATG/CsA. A total 77 patients were treated from June 2003 November 2005; 35 received h-ATG/CsA/sirolimus 42 The two groups well matched...
Although aplastic anemia and myelodysplasia have been extensively investigated, little is known about their circulating cytokine patterns. We compared plasma soluble cytokines in 33 anemia, 57 patients, 48 healthy controls. High levels of thrombopoietin granulocyte colony-stimulating factor, with low CD40 ligand, chemokine (C-X-C motif) ligand 5, (C-C 11, epidermal growth vascular endothelial 11 were a signature profile for anemia. tumor necrosis factor-α, interleukin-6, 3, interleukin-1...
INTRODUCTION: The safety of Helicobacter pylori eradication treatments and to what extent adverse events (AEs) influence therapeutic compliance in clinical practice are hardly known. Our aim was assess the frequency, type, intensity, duration AEs, their impact on compliance, for most frequently used “European Registry management.” METHODS: Systematic prospective noninterventional registry European gastroenterologists (27 countries, 300 investigators) management H. infection routine practice....
<b>Background:</b> Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury fibrogenesis animal models but little is known regarding their role hepatitis C virus (HCV) related liver disease humans. <b>Aims:</b> To characterise the intrahepatic expression pattern of COX-2 MMPs chronic HCV infection determine whether core NS5A proteins could promote cultured hepatocyte derived cell lines. <b>Patients:</b> Thirty two anti-HCV+ 10 anti-HCV− patients...
Persistent neutropenia associated with severe aplastic anemia (SAA) is an important risk factor for development of life-threatening infections. Earlier studies underscored the high mortality invasive fungal infections (IFIs) in SAA. However, little known about current patterns and impact advances anti-infective therapy on survival SAA.We reviewed records 174 patients SAA admitted to Hematology Branch at NHLBI from 1989 2008 who were unresponsive initial immunosuppressive (IST) 6 months....
Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and present about 40-50% patients with severe aplastic anemia. Flow cytometry has allowed for sensitive precise measurement red blood neutrophils anemia.We conducted a retrospective analysis clones measured by flow 207 consecutive anemia who received immunosuppressive therapy horse anti-thymocyte globulin plus cyclosporine regimen from 2000 to 2008.The presence...
There has been resurgence in the use of bismuth quadruple therapy (proton pump inhibitor, bismuth, tetracycline and metronidazole) for treating Helicobacter pylori infection thanks to a three-in-one single-capsule formulation.To evaluate effectiveness safety therapy.Data were collected multicentre, prospective registry clinical practice gastroenterologists on management H. infection, where patients registered at Asociación Española de Gastroenterologia REDCap database an electronic case...
Background. Previous reports have established the feasibility of using livers from controlled, non–heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out necessity because donor shortage. Methods. Retrospective database review for last 7 years (1995–2002), encompassing 19 patients receiving CNHBD, follow-up period 1,000±694 days, median 762 days. Detailed recipient characteristics, operative and clinical course, immunosuppression, complications,...
Summary Background Hepatic venous pressure gradient (HVPG) has prognostic value in complications and survival of patients with liver cirrhosis. However, the relationship between HVPG outcome acute alcoholic hepatitis (AAH), as well specific features portal hypertension syndrome this setting, have not been defined. Aims To evaluate to analyse degree hyperdynamic circulation severe AAH. Methods Early measurements were performed 60 AAH, compared haemodynamic findings 37 29 transplantation...
Bismuth quadruple therapies (BQTs) including bismuth, a proton pump inhibitor (PPI) and two antibiotics have been shown to be highly effective for treating
Abstract Objectives 68Ga-PSMA-HBED-CC positron emission tomography (PET)/computed (CT) represents a clinically relevant technique for the evaluation of prostate cancer (PCa) patients, whereas 18F-AIF-PSMA-HBED-CC is novel tracer produced in our center, with suitable radiochemical purity clinical purposes. We prospectively compared diagnostic values both tracers detection metastatic disease patients intermediate-/high-risk PCa at initial staging. Materials and Methods Sixty-six (mean age: 63...
Summary. Increased levels of chemokines (CK) in chronic hepatitis C virus (HCV) infection have been found. Given that NS5A and core can function as transcriptional transactivators, we aimed to determine whether these HCV proteins might induce CK gene expression human hepatocyte‐derived cells. We assessed (i) regulated upon activation, normal T cells expressed activated (RANTES), interferon γ ‐inducible protein‐10 (IP‐10), monokine induced by interferon‐ (MIG) mRNA stably transfected Chang...
Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein observed in biopsies from patients glomerulosclerosis scleroderma, respectively. Our aim was to evaluate whether endoglin may be hepatic fibrosis featuring chronic hepatitis C virus (HCV) infection. Fifty-two anti-HCV+ patients, five anti-HCV- 27 healthy subjects were studied. Western blot immunohistochemistry used quantify the expression...
Cases of renal tubular dysfunction have been reported in patients with hepatitis B and human immunodeficiency virus who are undergoing tenofovir treatment. However, little is known about the impact on function chronic (CHB) under long-term use entecavir (ETV) disoproxil fumarate (TDF). We evaluated markers bone turnover CHB treated ETV or TDF.A multicenter, cross-sectional study was performed virus-monoinfected treatment Entecavir Tenofovir (the MENTE study). The analyzed parameters were:...