A5035284525- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Liver physiology and pathology
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Pediatric Hepatobiliary Diseases and Treatments
- 3D Printing in Biomedical Research
- Neurological Complications and Syndromes
- Diverticular Disease and Complications
- Gastrointestinal Bleeding Diagnosis and Treatment
Hospital Clínico Universitario Lozano Blesa
2012-2023
Instituto de Investigación Sanitaria Aragón
2015-2023
Hospital General San Jorge
2021
Universidad de Zaragoza
2016
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016
The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures been interrupted delayed because COVID-19 pandemic.An international survey impact on clinical practice trials from March 2020 June 2020, as first phase a multicentre, international, observational project. focus was hepatocellular carcinoma intrahepatic...
Sorafenib (SOR) is the standard of care for patients with hepatocellular carcinoma (HCC) and portal vein invasion (PVI), based on results phase 3 trials. However, radioembolization (RE) using yttrium-90 microspheres has been shown to achieve higher response rates better survival in large cohorts 2 This study aimed compare HCC PVI treated by RE or SOR.Survival among SOR four Spanish hospitals between 2005 2013 was analysed retrospectively. Kaplan-Meier curves were plotted baseline variables...
// Alberto Lué 1, 2 , Maria Trinidad Serrano Francisco Javier Bustamante 3 Mercedes Iñarrairaegui 4, 5 Juan Ignacio Arenas 6 Milagros Testillano Sara Lorente Cristina Gil Manuel de la Torre 4 Alexandra Gomez and Bruno Sangro 1 Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, 50009, Zaragoza, Spain Instituto Investigación Sanitaria (IIS) Aragón, Cruces, Plaza 48903, Barakaldo, Liver Unit, Clinica Universidad Navarra-IDISNA, 31008, Pamplona, Centro Investigacion...
Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for and maintenance treatment these patients, although oral route has been demonstrated effective other pathologies impaired absorption. Our aims were evaluate efficacy of long-term disease. We performed a multicenter retrospective cohort study that included 94 deficiency. Seventy-six had B12 94.7% them normalized their levels treatment. The most used dose was 1...
Background Medication adherence is crucial in the management of patients with inflammatory bowel disease (IBD) because medication nonadherence these associated an increased risk flare-up, relapse, recurrence, loss response to anti-tumour necrosis factor agents, morbidity and mortality, poor quality life. Data on factors are very controversial literature. Aim To assess prevalence identify predictors low Spanish IBD. Patients methods We carried out a cross-sectional study that included...
Abstract Background & Aims Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed evaluate the rate, prevalence, tolerability, outcome sorafenib this population. Methods We report a multicenter study comprising Latin America Europe. Patients treated were enrolled; demographics, dose modifications, adverse events (AEs), duration, undergoing recorded....
Faecal occult blood test (FOBT) has demonstrated effectiveness in colorectal cancer (CRC) screening. calprotectin (FC) proven efficient for evaluating activity inflammatory bowel disease (IBD), but its value CRC detection is less established. Most symptomatic patients have benign pathologies, still undergo colonoscopy many settings.To evaluate the diagnostic accuracy and cost-effectiveness of combination FOBT plus FC patients.Patients who completed colonic investigations returned stool...
Introduction: The fecal immunochemical test (FIT) has been established as a cost-effective in colon cancer screening programmes. This could also be helpful symptomatic patients prior to colonoscopy, but data about diagnostic performance, and accurate cut-off values for these are still scarce. Materials Methods: Prospective study that included consecutive unselected with gastrointestinal symptoms referred colonoscopy between November 2016 June 2018. We performed FIT (FOB Gold® test, 20...
Calcineurin inhibitor-induced neurotoxicity (CIIN) is a common and debilitating side effect after liver transplantation (LT). Risk factors impact on patient outcomes are not well defined. Our aim was to assess the incidence, risk factors, clinical of CIIN.We retrospectively analyzed 175 LTs performed at our center between January 2010 September 2016. Donor recipient demographics as variables pre-LT, intra-LT, post-LT were assessed. All patients once-daily prolonged-release tacrolimus.CIIN...
Diverticular disease (DD) of the colon represents most common affecting large bowel in western countries. Its prevalence is increasing. Recent studies suggest that changes gut microbiota could contribute to development symptoms and complication. For this reason antibiotics play a key role management both uncomplicated complicated DD. Rifaximin has demonstrated be effective obtaining relief at 1 year patients with DD improve maintain periods remission following acute colonic diverticulitis...
Most colonoscopies performed to evaluate gastrointestinal symptoms detect only non-relevant pathologies. We aimed the diagnostic accuracy of a qualitative point-of-care (POC) test combining four biomarkers (haemoglobin, transferrin, calprotectin, and lactoferrin), quantitative faecal immunochemical (FIT) for haemoglobin, calprotectin (FC) in symptomatic patients prospectively recruited. Colorectal cancer (CRC), adenoma requiring surveillance, inflammatory bowel disease (IBD), microscopic...
Abstract Background and objective Different factors may influence colonoscopy performance measures. We aimed to analyze procedure‐ endoscopist‐related associated with detection of colorectal lesions whether these have a similar in the context different indications: positive fecal immunochemical test (+FIT) post‐polypectomy surveillance colonoscopies. Methods This multicenter cross‐sectional study included adults aged 40–80 years. Endoscopists ( N = 96) who had performed ≥50 examinations were...
Background: Screening with fecal occult blood test reduces colorectal cancer (CRC) incidence and mortality, is currently implemented in most countries. However, around 40% of screening colonoscopies are normal. Thus, strategies to avoid these highly necessary. Adding other biomarkers, such as calprotectin (FC), lactoferrin, transferrin may be useful, but evidence scarce. Aims: To evaluate the diagnostic accuracy immunochemical (FIT), FC, a one-step combo card for simultaneous...
Liver resections are a significant source of primary human hepatocytes used mainly in artificial liver devices and pharmacological biomedical studies. However, it is not well known how patient-donor surgery-dependent factors influence isolated hepatocytes' yield, viability, function. Hence, we aimed to analyze the impact all these elements on outcome hepatocyte isolation.Hepatocytes were from tissue patients undergoing partial hepatectomy using two-step collagenase method. Hepatocyte cell...
Introducción: existen diversos indicadores para la valoración de supervivencia del injerto hepático (DRI americano y ET-DRI europeo, entre otros), pero diferencias importantes los programas trasplante diferentes países podría ser que dichos no sean válidos en nuestro medio. Objetivos: