A5074192444- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- RNA modifications and cancer
- Microscopic Colitis
- Diverticular Disease and Complications
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Hidradenitis Suppurativa and Treatments
- Public Health and Environmental Issues
- Antenna Design and Analysis
- MicroRNA in disease regulation
- Blood donation and transfusion practices
Instituto de investigación sanitaria y biomédica de Alicante
2017-2023
Hospital General Universitario de Alicante Doctor Balmis
2016-2023
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2017-2019
Universidad Complutense de Madrid
2019
Hospital General Universitario Gregorio Marañón
2019
Hospital General Universitario de Elche
2018
Universitat de Miguel Hernández d'Elx
2016
<b>Background and study aim:</b> Several factors have been shown to be related colonoscopy quality; however, little is known about the effects of endoscopist factors. This analyzed influence endoscopist-related characteristics on quality indicators for colonoscopy. <b>Patients methods:</b> The included 48 endoscopists who each performed at least 20 colonoscopies in arm a randomized controlled trial comparing fecal immunochemical test vs. colorectal cancer screening. These total 3838...
Population-based fecal tests for colorectal cancer (CRC) screening have shown to reduce mortality thanks the early detection of disease. However, currently available are limited in their sensitivity and specificity. Our aim is look volatile organic compounds samples as biomarkers CRC detection.Eighty participants were included; 24 had adenocarcinoma, adenomatous polyps 32 presented no neoplasms. Fecal collected 48 h preceding colonoscopy from all participants, except patient that after 3-4...
Objective The aim of this study was to validate a molecular classification colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS investigate each subtype's response chemotherapy. Design This retrospective observational included population-based cohort 878 CRC patients. We classified tumours into five different subtypes BRAF mutation, CIMP MSI. Patients with advanced stage II (T4N0M0) III received 5-fluoruracil...
High-risk features of colonic polyps are based on size, number, and pathologic characteristics. Surveillance colonoscopy is often recommended according to these findings. This study aimed determine whether the molecular characteristics might provide information about risk metachronous advanced neoplasia.We retrospectively included 308 patients with polyps. A total 995 were collected tested for somatic BRAF KRAS mutations. Patients classified into 3 subgroups, polyp mutational profile at...
Background Guidelines recommend surveillance colonoscopies based exclusively on findings at baseline colonoscopy. This recommendation leads to the paradox that higher colonoscopy quality, more will be indicated according current guidelines. Objective The aim of this study was evaluate effect follow‐up different quality metrics endoscopist performing Methods retrospective cohort included individuals with advanced adenomas Adenoma detection rate (ADR) and per (APCR) were determined for 44...
Abstract Background Current guidelines regarding surveillance after screening colonoscopy assume adequate bowel preparation. However, follow-up intervals suboptimal cleansing are highly heterogeneous. We aimed to determine the diagnostic yield of early repeat in patients with preparation fecal immunochemical test (FIT)-based colonoscopy. Methods An observational study including who underwent positive FIT and then within 1 year. Suboptimal was defined as a Boston Bowel Preparation Scale...
Purpose: A recent study reported that 5-fluorouracil (5-FU)-based chemotherapy is less effective in treating patients with advanced colorectal cancer demonstrating hypermethylation of the TFAP2E gene. The aim our was to confirm and validate these findings large, uniformly treated, well-characterized patient cohorts.Experimental Design: Two cohorts 783 cancer: 532 from a population-based, multicenter cohort (EPICOLON I) 251 clinic-based trial were used effectiveness methylation expression as...
Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like (LLS). We compared the risk in first-degree relatives (FDRs) LLS and LS patients. was diagnosed when tumors showed immunohistochemical loss MSH2, MSH6, PMS2; or MLH1 with BRAF wild type; and/or no methylation absence mutation these genes. other LS-related neoplasms were followed among their FDRs....
Abstract Background and objective Different factors may influence colonoscopy performance measures. We aimed to analyze procedure‐ endoscopist‐related associated with detection of colorectal lesions whether these have a similar in the context different indications: positive fecal immunochemical test (+FIT) post‐polypectomy surveillance colonoscopies. Methods This multicenter cross‐sectional study included adults aged 40–80 years. Endoscopists ( N = 96) who had performed ≥50 examinations were...
The utility of molecular markers for predicting the risk metachronous advanced colorectal lesions (MACLs) remains poorly investigated. We examined relationship between somatic hypermethylation in polyps at baseline and developing MACL. This retrospective cohort study included 281 consecutive patients with colonic who were enrolled 2007 2009 followed-up until 2014. MACLs defined as adenomas ≥10 mm, high-grade dysplasia, or a villous component; serrated mm dysplasia. In total, 595 removed...
While clinical practice guidelines for hereditary diffuse gastric cancer are well established, there is no consensus on the approach familial intestinal (FIGC). In low-incidence (GC) areas such as United States or most European countries, evidence-based recommendations endoscopic assessment in FIGC families. We aim to describe yield of GC surveillance these families, and identify epidemiological risk factors development its precursor lesions. This a multicenter observational study involving...
Accumulating evidence supports the fact that mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative particular CRC subtype with distinct clinical and molecular features. In addition, prognostic significance carcinoma (MC) remains poorly understood biomarkers have been barely explored this disease. Herein, we performed systematic comprehensive analysis MCs non-MCs identified panel microRNAs (miRNAs) are...
Patients with multiple or large adenomas are considered to be high-risk for metachronous colorectal cancer.Evaluate the risks of detecting cancer, advanced adenoma, and serrated polyps at 1-year surveillance colonoscopy in patients >5 >20 mm.Descriptive, retrospective, multicentric, cohort study. We calculated absolute risk developing adenomas, colonoscopy. Potential factors neoplasia follow-up were evaluated univariable multivariable logistic regression analyses.This study included data...
Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels glucose, insulin, C-reactive protein (CRP) in polyps.Eighty-three 10 more adenomatous serrated 53 control people normal colonoscopy were included. Smoking habits registered, CRP, basal insulin serum/blood measured. Quantification IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, IL-23 cytokine serum performed by high-sensitivity...