A5100650075- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Down syndrome and intellectual disability research
- Advanced MRI Techniques and Applications
- Brain Tumor Detection and Classification
- RNA regulation and disease
- Cardiovascular Health and Disease Prevention
- Mitochondrial Function and Pathology
- MRI in cancer diagnosis
- Epilepsy research and treatment
- Genetic Associations and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cognitive Functions and Memory
- Neurobiology of Language and Bilingualism
- Language Development and Disorders
- Machine Learning in Healthcare
- Genetic Syndromes and Imprinting
- Neurological diseases and metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Artificial Intelligence in Healthcare
Fundacion Centro De Investigacion De Enfermedades Neurologicas
2020-2025
Instituto de Salud Carlos III
2024-2025
Dartmouth College
2025
Alzheimer’s Disease Neuroimaging Initiative
2024
Universidad Politécnica de Madrid
2017-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2024
Hospital Universitario Reina Sofía
2020
Massachusetts General Hospital
2016
Harvard University
2016
University of Hong Kong
2010-2013
Cognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life the memory function of individuals 30 years younger. We aimed to characterise brain structure superagers and identify demographic, lifestyle, clinical factors associated this phenotype.
Between 2.5 and 28% of people infected with SARS-CoV-2 suffer Long COVID or persistence symptoms for months after acute illness. Many are neurological, but the brain changes underlying neuropsychological impairments remain unclear. This study aimed to provide a detailed description cognitive profile, pattern alterations in potential association between them. To address these objectives, 83 patients persistent neurological COVID-19 were recruited, 22 now healthy controls chosen because they...
Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable. In a sample 64 superagers (mean age, 81.9; 59% women) 55 typical older adults 82.4; 64% from Vallecas Project, we studied, cross-sectionally longitudinally over 5 yearly follow-ups, global cerebral white matter status as well region-specific microstructure assessment derived diffusivity measures. showed no difference in health (total...
Quantitative MRI of the hippocampus has been increasingly employed as a biomarker in Alzheimer's disease (AD). We compare voxel-based morphometry (VBM) standard and DARTEL registration with manual hippocampal volumetry AD patients cognitively
Abstract Lewy body (LB) pathology is present as a co-pathology in approximately 50% of Alzheimer’s disease (AD) dementia patients and may even represent the main neuropathologic substrate subset with amnestic impairments. However, degree to which LB affects neurodegenerative course clinical phenotype not well understood. Recently developed α-synuclein seed amplification assays (αSyn-SAAs) provide unique opportunity for further investigating complex interplay between AD shaping heterogeneous...
ABSTRACT INTRODUCTION Hippocampal sclerosis of aging (HS-aging) is frequently present in individuals over 85 who die with dementia. Recent studies suggest that some loci associated Alzheimer’s disease (AD) may be more related to HS-aging. We aimed find AD-associated SNPs potentially METHODS assessed the relation AD polygenic risk score (AD-PRS) hippocampal subfield volumes by magnetic resonance imaging (MRI) as HS-by-proxy 1,130 non-demented participants. analyzed 1,708 associate their...
The Post-acute Sequela of SARS-CoV-2 (PASC) syndrome, also known as Long-COVID, often presents with subjective symptoms such brain fog and cognitive fatigue. Increased tinnitus, decreased hearing in noise ability occur PASC, yet whether auditory manifestations PASC are linked the is not known. Electrophysiology, specifically Auditory Brainstem Response (ABR), provides objective measures processing. We hypothesized that ABR findings would be to feelings Eighty-two individuals, 37 (mean age:...
<title>Abstract</title> <bold>BACKROUND</bold>: Hippocampal sclerosis of aging (HS-aging) is frequently present in individuals over 85 who die with dementia. Recent studies suggest that some loci associated Alzheimer’s disease (AD) may be more related to HS-aging. We aimed find AD-associated SNPs potentially <bold>METHODS</bold>: used different regression models assess the relation AD polygenic risk score (AD-PRS) hippocampal subfield volumes assessed by magnetic resonance imaging (MRI) as...
ABSTRACT Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable. In a sample 64 superagers (mean age 81.9; 59% women) 55 typical older adults 82.4; 64% from Vallecas Project, we studied, cross-sectionally longitudinally over 5 yearly follow-ups, global cerebral white matter status as well region-specific microstructure assessment derived diffusivity measures. showed no difference in...
Quantitatively predicting the progression of Alzheimer's disease (AD) in an individual on a continuous scale, such as Disease Assessment Scale-cognitive (ADAS-cog) scores, is informative for personalized approach opposed to qualitatively classifying into broad category. To evaluate hypothesis that multi-modal data and predictive learning models can be employed future ADAS-cog scores. Unimodal regression were trained baseline comprised demographics, neuroimaging, cerebrospinal fluid based...
Memory normally declines with ageing and these age-related cognitive changes are associated in brain structure. Episodic memory retrieval has been widely studied during ageing, whereas learning received less attention. Here we examined the neural correlates of episodic rate ageing. Our study sample consisted 982 cognitively healthy female male older participants from Vallecas Project cohort, without a clinical diagnosis mild impairment or dementia. The across three consecutive recall trials...
The relative importance of different components cognitive reserve (CR), as well their differences by gender, are poorly established.
ABSTRACT Identifying measures that predict future cognitive impairment in healthy individuals is necessary to inform treatment strategies for candidate dementia-preventative and modifying interventions. Here, we derive such by studying “converters” who transitioned from cognitively normal at baseline mild-cognitive (MCI) a longitudinal study of 1213 elderly participants. We first establish reduced grey matter density (GMD) left entorhinal cortex (EC) as biomarker impending decline...
Abstract Objective Alzheimer's disease (AD) is a major health concern for aging adults with Down syndrome (DS), but conventional diagnostic techniques are less reliable in those severe baseline disability. Likewise, acquisition of magnetic resonance imaging to evaluate cerebral atrophy not straightforward, as prolonged scanning times tolerated this population. Computed tomography (CT) scans can be obtained faster, poor contrast resolution limits its function morphometric analysis. We...
A gradual decline in memory as we get older is not abnormal, but some people do experience significant cognitive they age.Termed "superagers," these individuals have good a those 30 years younger.Scientists begun to leverage this phenomenon tool explore neuroprotective mechanisms for loss and dementia.In issue, Garo-Pascual et al. present their findings from 5 year longitudinal study which the brain structure of superagers was compared with that adults experiencing typical loss.The authors...
Abstract Background KLOTHO‐VS heterozygosity (KL‐VS het+ ) has been posited to be a protective factor against age‐related disease and cognitive decline, having associated with increased cortical volumes brain connectivity, as well improved cognition in healthy elderly individuals. Conversely, the APOE‐ε4 allele is primary risk for development of Alzheimer’s (AD), ε4 carriers more likely have greater β‐amyloid burden, earlier age AD onset, accelerated rates decline. Relatively few studies...
Abstract Background KLOTHO‐VS heterozygosity (KL‐VShet+) has been posited to be a protective factor against age‐related disease and cognitive decline, having associated with increased cortical volumes brain connectivity, as well improved cognition in healthy elderly individuals. Conversely, the APOE‐e4 allele is primary risk for development of Alzheimer’s (AD), e4 carriers more likely have greater ß‐amyloid burden, earlier age AD onset, accelerated rates decline. Relatively few studies...
Abstract Background Superagers are people over the age of 80 that possess an episodic memory function a person 20‐30 years younger. By drawing on large (N=1213) longitudinal cohort elderly individuals, we aimed to identify superager subgroup and determine key differences, including brain structure, between superagers peers with normal for their age. Method A sample 64 (mean 81.9 years, 59.4% women) 19 age‐matched controls 82.6 57.9% from Vallecas Project based at Fundación CIEN were selected...
Quantitative Magnetic Resonance Imaging (MRI) of the hippocampus has been increasingly employed as biomarker in diagnosis, monitoring disease progression and drug treatment Alzheimer's (AD) patients. We attempt to compare efficacy two techniques i.e. manual hippocampal volumetry voxel-based morphometry (VBM) a local Chinese cohort AD patients cognitively normal older adults. Participants this prospective study consisted 20 elderly subjects (17 females, 3 males), 19 (14 5 males) who met...
Abstract Background: Quantitatively predicting the progression of Alzheimer’s disease (AD) in an individual on a continuous scale, such as AD assessment scale-cognitive (ADAS-cog) scores, is informative for personalized approach opposed to qualitatively classifying into broad category. We hypothesize that multi-modal data and predictive learning models can be employed longitudinally ADAS-cog scores. Methods: Multivariate regression techniques were model baseline (demographics, neuroimaging,...