A5040427845- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Radiology practices and education
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Cognitive Abilities and Testing
- Neurological Disorders and Treatments
- Healthcare Systems and Public Health
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Education and Teacher Training
- COVID-19 diagnosis using AI
- COVID-19 and Mental Health
- Frailty in Older Adults
- Down syndrome and intellectual disability research
- Radiation Dose and Imaging
- Neuroscience and Neuropharmacology Research
- Cognitive Science and Mapping
Fundacion Centro De Investigacion De Enfermedades Neurologicas
2012-2025
Instituto de Salud Carlos III
2021-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2018
Neuroimaging studies provide evidence for organized intrinsic activity under task-free conditions. This serves functionally relevant brain systems supporting cognition. Here, we analyze changes in resting-state functional connectivity after videogame practice applying a test-retest design. Twenty young females were selected from group of 100 participants tested on four standardized cognitive ability tests. The and control groups carefully matched their scores. played during two sessions per...
The older population has been especially affected by the severe acute respiratory syndrome coronavirus 2 pandemic (COVID-19).
Objective: A cross-sectional study was conducted to describe the prevalence, locations, and risk factors for brain microbleeds (BMBs) in neurodegenerative dementia. Methods: The database of Alzheimer Center Reina Sofía Foundation searched, BMBs were described, potential associations investigated using univariate statistics. Results: total 148 patients (age 81.6 [standard deviation 6.7], 79.1% female) studied. Prevalence 44.6%. group with unusually high (ie, ≥4) number identified, which...
Objective: We conducted a longitudinal study to explore the clinical and pathological correlates of cerebral microbleeds (CMBs) in institutionalized patients with dementia. Methods: Clinical magnetic resonance imaging (MRI) data were extracted from 182 nursing home (mean age [standard deviation]: 81.3 [6.9], 78.0% female, 83.4% moderate severe dementia), which divided according CMBs number location. One-year follow-up obtained 153 patients, postmortem diagnosis was available 40 patients....
ABSTRACT Identifying measures that predict future cognitive impairment in healthy individuals is necessary to inform treatment strategies for candidate dementia-preventative and modifying interventions. Here, we derive such by studying “converters” who transitioned from cognitively normal at baseline mild-cognitive (MCI) a longitudinal study of 1213 elderly participants. We first establish reduced grey matter density (GMD) left entorhinal cortex (EC) as biomarker impending decline...
Abstract Background KLOTHO‐VS heterozygosity (KL‐VS het+ ) has been posited to be a protective factor against age‐related disease and cognitive decline, having associated with increased cortical volumes brain connectivity, as well improved cognition in healthy elderly individuals. Conversely, the APOE‐ε4 allele is primary risk for development of Alzheimer’s (AD), ε4 carriers more likely have greater β‐amyloid burden, earlier age AD onset, accelerated rates decline. Relatively few studies...
Abstract Background KLOTHO‐VS heterozygosity (KL‐VShet+) has been posited to be a protective factor against age‐related disease and cognitive decline, having associated with increased cortical volumes brain connectivity, as well improved cognition in healthy elderly individuals. Conversely, the APOE‐e4 allele is primary risk for development of Alzheimer’s (AD), e4 carriers more likely have greater ß‐amyloid burden, earlier age AD onset, accelerated rates decline. Relatively few studies...
Abstract Background Cardiovascular disease is associated with increased risk of developing mild cognitive impairment (MCI) and Alzheimer’s (AD), although the underlying mechanisms are not well understood. While it has been theorised that cerebral hypoperfusion caused by heart failure may directly lead to formation amyloid plaques neurofibrillary tangles characteristic AD, also suggested decreased perfusion occurs later in progression. We used arterial spin labelling (ASL) MRI compare blood...
Abstract Background Cardiovascular disease is associated with increased risk of developing mild cognitive impairment (MCI) and Alzheimer’s (AD), although the underlying mechanisms are not well understood. While it has been theorised that cerebral hypoperfusion caused by heart failure may directly lead to formation amyloid plaques neurofibrillary tangles characteristic AD, also suggested decreased perfusion occurs later in progression. We used arterial spin labelling (ASL) MRI compare blood...