A5100364594- Synthetic Organic Chemistry Methods
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Plant Stress Responses and Tolerance
- Systemic Sclerosis and Related Diseases
- Plant tissue culture and regeneration
- Research in Cotton Cultivation
- Hepatitis C virus research
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Catalytic Cross-Coupling Reactions
- Fungal Biology and Applications
- Immune Cell Function and Interaction
- Treatment of Major Depression
- Chemokine receptors and signaling
- Fish biology, ecology, and behavior
- Sirtuins and Resveratrol in Medicine
- Transplantation: Methods and Outcomes
- Bladder and Urothelial Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Invertebrate Immune Response Mechanisms
- Extracellular vesicles in disease
- Renal cell carcinoma treatment
- Autoimmune and Inflammatory Disorders
- Animal Disease Management and Epidemiology
- Ureteral procedures and complications
Ningbo Medical Center Lihuili Hospital
2024
Second Affiliated Hospital of Zhejiang University
2021-2023
Institute of Medicinal Plant Development
2022
Shandong Agricultural University
2019-2020
Integrated Chinese Medicine (China)
2014-2020
Lanzhou Veterinary Research Institute
2019
Chinese Academy of Agricultural Sciences
2019
Nanjing Agricultural University
2017-2018
Zhoushan Hospital
2013-2018
Hangzhou Normal University
2015-2016
A chiral N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition reaction of imines and oxindole-derived enals was developed for rapid access to spirocylic oxindoles. In most cases, the desired oxindole products were obtained in high yields excellent enantioselectivities with less than 1 h time.
Catalases (CATs), which were coded by the catalase gene family, a type notably distinguished ROS-metabolizing proteins implicated to perform various physiological functions in plant growth, development and stress responses. However, no systematical study has been performed cotton. In present study, we identified 7 CAT genes genome of Gossypium hirsutum L. Additionally, G. barbadense L., respectively. The results phylogenetic synteny analysis showed that divided into two groups, whole-genome...
Salinity stress is a major abiotic affecting the productivity and fiber quality of cotton. Although reactive oxygen species (ROS) play critical roles in plant responses, their complex molecular regulatory mechanism under salinity largely unknown cotton, especially microRNA (miRNA)-mediated regulation superoxide dismutase gene expression. Here, we report that cotton iron GhFSD1 miRNA ghr-miR414c work together response to stress. The targets coding sequence region GhFSD1, inhibiting expression...
An N-heterocyclic carbene-catalyzed highly enantioselective [3 + 3] annulation reaction of N-hydroxyphthalimide (NHPI) 3,3-disubstituted acrylates and N-Ts ketimines was developed. In most cases, the desired chiral dihydropyridinone products bearing an all carbon quaternary stereogenic center could be obtained in good yields with excellent enantioselectivities (>99% ee's), which demonstrated NHPI as a kind substrate NHC-catalysis.
Abstract Background Plant NADPH oxidase (NOX), also known as respiratory burst homolog (rboh), encoded by the rboh gene, is a key enzyme in reactive oxygen species (ROS) metabolic network. It catalyzes formation of superoxide anion (O 2 •− ), type ROS. In recent years, various studies had shown that members plant gene family were involved growth and developmental processes well biotic abiotic stress responses, but little about its functional role upland cotton. Results present study, 26...
Systemic sclerosis (SSc) is a connective tissue fibrotic disease for which there no effective treatment. Traditional Chinese Medicine (TCM), such as the Yiqihuoxue formula used in Shanghai TCM-integrated Hospital, has shown efficacy of anti-fibrosis clinical applications. This study was aiming to dissect anti-fibrotic mechanism treatment SSc. Bleomycin-induced mice and SSc dermal fibroblasts were treated with decoction; NIH-3T3 exposed exogenous TGF-β1, then cultured or without decoction....
Background Ketamine was developed as an anesthetic. Esketamine is the isolated S-enantiomer of racemic ketamine. They provide new avenues for treatment depression, especially treatment-resistant depression. Considering differences in pharmacokinetics and hormonal status ketamine patients different genders, sex-based esketamine adverse drug events (ADE) may also be observed. This study presents data mining safety analysis between promoting individualization clinical practice. Methods Adverse...
The sequence variation within the capsid proteins occurs frequently in infection of susceptible tissue cultures, reflecting high levels genetic diversity FMDV. A systematic study for functional significance isolate-specific residues VP0 and VP3 FMDV PanAsia-1 strains suggested that interaction amino acid side chains between N terminus VP4 several potential domains VP1-3 had cascading effects on viability developmental characteristics progeny viruses. Y2079H indicated FMDVs could affect...
Our previous study has demonstrated that TF/FVIIa and PAR2 are closely related to the proliferation migration of colon cancer cell line SW620. However, detailed molecular mechanisms in process remain unclear. This further investigated whether some important molecules (caspase-3, MMP-9 CD44) involved events. The results showed PAR2-AP or FVIIa elicited time-dependent downregulation caspase-3, up-regulation CD44 SW620 cells. effects were TF-dependent involving PAR2/MAPKs/NF-κB signal...
Flammulina velutipes is a well-known edible mushroom cultivated all over the world. However, because of low transformation frequency, expensive instruments required, and complicated, time-consuming procedures necessary, there insufficient genetic research on F. velutipes. In this study, we report liposome-mediated (LMT) system for Using LMT system, obtained 82 ± 4 stable transformants per 105 protoplasts, which clear increase in frequency compared to other methods used. We were able detect...
This study examined the short- and long-term neuroprotective analgesic activity of honokiol (a naturally occurring lignan isolated from Magnolia) on developing brains in neonates exposed to inflammatory pain, known cause neuronal cell death. Postnatal day 4 (P4) neonatal rat pups were subjected intraplantar formalin injection four paws as a model severe pain. Intraperitoneal (10 mg/kg) or corn oil vehicle control was administered 1 h prior insult, animals maintained through postnatal 21...
SUMMARY This paper describes the cloning and functional characterization of heart muscle isoform Sarco/endoplasmic reticulum Ca2+-ATPase(SERCA) from crayfish Procambarus clarkii. The complete SERCA, identified by reverse transcription-polymerase chain reaction(RT-PCR) rapid amplification cDNA ends (RACE), consists 4495 bp with a 3060 open reading frame, coding for 1020 amino acids. differs previously axial abdominal (tail) SERCA solely in its C-terminal last nine acids tail are replaced 27...
NA is a crucial surface antigen and drug target of influenza A virus. comprehensive understanding NA's mutational effect resistance profiles
We conducted a systematic bioinformatics analysis to explore an important set of gene expression data with 39 samples infected at different time stages withW-Beijing families Mycobacterium tuberculosis strains. took contrast on the infection characterize features THP1 cells identify sensitive and specific molecular markers for diagnosis. first confirmed, through multidimensional scaling unsupervised clustering, that were clustered well according times. Building this classification result...
RNA viruses, such as hepatitis C virus (HCV), influenza virus, and SARS-CoV-2, are notorious for their ability to evolve rapidly under selection in novel environments. It is known that the high mutation rate of viruses can generate huge genetic diversity facilitate viral adaptation. However, less attention has been paid underlying fitness landscape represents forces on genomes, especially different conditions. Here, we systematically quantified distribution effects about 1,600 single amino...
Abstract The [3 + 3]‐cyclization reaction of N‐hydroxyphthalimide acrylates with N‐tosyl ketimines proceeds in moderate to high yields and excellent enantiomeric excess.