A5072970065- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
- interferon and immune responses
- Microbial Inactivation Methods
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Antimicrobial Peptides and Activities
- Influenza Virus Research Studies
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
Roche (Switzerland)
2015-2024
Roche (China)
2017-2023
The University of Sydney
1995-2022
Salk Institute for Biological Studies
2008-2017
Hewlett-Packard (United States)
1983-2014
University of Utah
2014
University of Wisconsin–Madison
2000-2007
Harvard University
1996-2007
Vanderbilt University Medical Center
2007
Yale University
2005
Bacillus anthracis secretes two bipartite toxins thought to be involved in anthrax pathogenesis and resulting death of the host. The current model for intoxication is that protective antigen (PA) toxin subunits bind a single group cell-surface receptors (ATRs), encoded by tumor endothelial marker 8 ( TEM8 ) gene. ATR/TEM8-PA interaction mediated receptor's extracellular domain related von Willebrand factor type A or integrin inserted domains (VWA/I domains). metal ion-dependent adhesion site...
To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense system composed of clustered regularly interspaced short palindromic repeats (CRISPRs), together with CRISPR-associated genes (Cas). The CRISPR/Cas9 develops an adaptive immune resistance to foreign plasmids viruses by creating site-specific DNA double-stranded breaks (DSBs). Here we adapt the human cells for intracellular against viruses. Using HIV-1 infection as model, our results demonstrate that...
Abstract Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options 1 . No new antibiotic chemical class activity against A. reached patients in over 50 years Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics potent antibacterial CRAB. The mechanism action this molecule involves blocking transport bacterial lipopolysaccharide from inner membrane to its destination on outer...
Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of roles these in replication cycle suggested that correct trafficking through may facilitate subsequent integration step. Here we present data coupling between steps by demonstrating depletion Transportin-3 or RanBP2 altered terminal step early replication, selection chromosomal sites...
We used a genetic strategy to isolate the chicken gene believed encode receptor for subgroup A avian leukosis and sarcoma viruses (ALSV-A). Chicken genomic DNA was transfected into monkey COS-7 cells, two independent primary transfectants susceptible ALSV-A infection were identified by using vectors containing hygromycin B resistance gene. second round of transfection selection in mouse BALB/3T3 fibroblasts again led isolation transfectant ALSV-A. Plasmid sequences linked during segregated...
Journal Article STATISTICAL METHODS APPLIED TO THE DIAGNOSIS OF HYPOTHYROLDISM Get access W. Z. BILLEWICZ, BILLEWICZ 1The Departments of Therapeutics and Pharmacology, Statistics, University Aberdeen, the Obstetrics Medicine Research Unit, Western InfirmaryGlasgow Search for other works by this author on: Oxford Academic PubMed Google Scholar R. S. CHAPMAN, CHAPMAN J. CROOKS, CROOKS M. E. DAY, DAY GOSSAGE, GOSSAGE SIR EDWARD WAYNE, WAYNE A. YOUNG QJM: An International Medicine, Volume 38,...
The U.S. has not responded wholeheartedly or effectively to the challenge of international competition. Our competitive position is eroding. Reversing this trend requires more than new tactics roles for government—government performed role it already has. This article based on report President9s Commission Industrial Competitiveness, which was chaired by author.
Abstract Heteroaryldihydropyrimidine (HAP) and sulfamoylbenzamide (SBA) are promising non-nucleos(t)ide HBV replication inhibitors. HAPs known to promote core protein mis-assembly, but the molecular mechanism of abnormal assembly is still elusive. Likewise, status induced by SBA remains unknown. Here we show that SBA, unlike HAP, does not mis-assembly. Interestingly, two reference compounds HAP_R01 SBA_R01 bind same pocket at dimer-dimer interface in crystal structures Y132A hexamer. The...
Highlights•RG7834 is a novel orally bioavailable HBV viral gene expression inhibitor.•The effect of RG7834 on levels highly virus-specific.•The unique antiviral profile differentiated from that nucleos(t)ide analogues.•Combination with entecavir and/or PegIFNα improves the and potency.Graphical abstractAbstractBackground & AimsThe hallmarks chronic infection are high load (HBV DNA) even higher (>100-fold in excess virions) non-infectious membranous particles containing tolerogenic S antigen...
Investment, collaboration, and coordination have been key