A5014466083- Analytical Chemistry and Chromatography
- Extraction and Separation Processes
- Analytical chemistry methods development
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- Organophosphorus compounds synthesis
- Drug Transport and Resistance Mechanisms
- Radioactive element chemistry and processing
- Pesticide and Herbicide Environmental Studies
- 3D Printing in Biomedical Research
- Molecular Sensors and Ion Detection
- Mass Spectrometry Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Characterization
- Biosensors and Analytical Detection
- Crystallization and Solubility Studies
- Parkinson's Disease Mechanisms and Treatments
- Ionic liquids properties and applications
- Advancements in Battery Materials
- Electrochemical Analysis and Applications
- Forensic Toxicology and Drug Analysis
- Chemical and Physical Properties in Aqueous Solutions
- Pharmacological Effects and Assays
- Molecular Biology Techniques and Applications
Roche (Switzerland)
2014-2024
Pfizer (United Kingdom)
2016
Pfizer (United States)
2007-2011
University of Opole
1998-2009
University of Milan
2007-2008
Lund University
1998
Abstract Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options 1 . No new antibiotic chemical class activity against A. reached patients in over 50 years Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics potent antibacterial CRAB. The mechanism action this molecule involves blocking transport bacterial lipopolysaccharide from inner membrane to its destination on outer...
The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model frontotemporal dementia. However, which cannabinoid receptors are mediating these benefits is still pending to be elucidated. We have investigated the involvement CB1 and CB2 receptor using chronic treatments with selective ligands analysis cognitive deterioration Novel Object Recognition test, immunostaining for neuronal glial markers...
Abstract The efficient resolution of racemic N ‐benzyl α‐amino acids ( ‐Bn‐AA) has been achieved by a liquid‐liquid extraction process using the lipophilic chiral salen–cobalt(III) complex [Co III 3 )(OAc)]. As result extraction, one enantiomer S ) acid predominated in aqueous phase, while other R was driven into organic phase complexation to cobalt. complexed amino then quantitatively released reductive (Co → Co II counter‐extraction with sodium dithionite or L ‐ascorbic methanol....
Abstract The possible application of Aliquat 336 (trioctylmethyl ammonium chloride) as a carrier for liquid membrane extraction amino acids was investigated. is performed from an aqueous donor phase with pH > 11 to acceptor containing salt solution through supported in the facilitate acid transport. Counter-coupled transport chloride anions driving force mass transfer this system. efficiency depends on pH, concentration membrane, composition and hydrophobicity acid. observed stability such...
Tissue analysis has always been a difficult discipline of bioanalysis. Differences in scientific approaches or level adherence to regulated guidelines have led growing ambiguity on how perform tissue analysis, an that starts with the question if we analyze homogenates. The European Bioanalysis Forum (EBF) is proposing recommendation method establishment and based broad discussions survey data from EBF community and, as for many recommendations, focuses finding right balance between science,...
Antisense oligonucleotides (ASOs) are chemically modified nucleic acids with therapeutic potential, some of which have been approved for marketing. We performed a study in rats to investigate mechanisms toxicity after administration 3 tool locked acid (LNA)-containing ASOs differing established safety profiles. Four male per group were dosed once, 3, or 6 times subcutaneously, 7 days between dosing, and sacrificed the last dose. These either unconjugated (naked) conjugated...
Abstract Studies on the possible use of phosphate and phosphonate esters bearing chiral menthol or nopol moieties as carriers for transport amines, amino acids, acid through supported liquid membranes (SLM) are presented. Additionally, enantioselectivity SLM alkyl aromatic acids a non‐protein was also evaluated. It could be concluded that extent strongly depends hydrophobicity compound. Moreover, carrier structure influences those compounds SLM: appear to poor moderate enantioselective their...
The efficient (up to 93% ee) resolution of racemic N-benzyl β3-amino acids has been achieved by an iterative (two cycle) liquid–liquid extraction process using a lipophilic chiral (salen)cobalt(III) complex [CoIII(1)(OAc)]. As result the extraction, one enantiomer acid predominated in aqueous phase, while other was driven into organic phase complexation cobalt. complexed amino then quantitatively released reductive (CoIII → CoII) counter-extraction L-ascorbic acid. cleavage allowed for...
The application of supported liquid membrane (SLM) extraction for the enrichment short peptides is presented. efficiency dependent on pH donor phase and salt concentration in acceptor phase. Moreover, also influenced by peptide amino-acid sequence hydrophobicity.
Use of the supported liquid membrane (SLM) technique for (aminomethyl)phosphonic acid (AMPA) extraction is presented. For this analyte a suitable SLM system involves containing Aliquat 336 – cationic carrier that facilitates AMPA transport. The compound, as in case glyphosate, dependent on donor phase pH and concentration type counter-ion acceptor phase, although some differences are also observed. In both cases transport mechanism counter-coupled which driving force mass over created by...