A5033826711- Neuroscience and Music Perception
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Literacy and Educational Practices
- Hearing Loss and Rehabilitation
- EEG and Brain-Computer Interfaces
- Health and Lifestyle Studies
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease Mechanisms and Treatments
- Spanish Linguistics and Language Studies
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Hearing, Cochlea, Tinnitus, Genetics
- Memory and Neural Mechanisms
- Intensive Care Unit Cognitive Disorders
- Literature, Culture, and Aesthetics
- Analog and Mixed-Signal Circuit Design
- Youth, Drugs, and Violence
- Health Promotion and Cardiovascular Prevention
- Health, Environment, Cognitive Aging
- Immigration and Intercultural Education
- Employment, Labor, and Gender Studies
- Music Therapy and Health
VA San Diego Healthcare System
2019-2024
University of California, San Diego
2018-2024
Mental Illness Research, Education and Clinical Centers
2019-2024
University of South Florida
2015-2021
VA Desert Pacific Healthcare Network
2021
National Institute of Mental Health
2016
University of Miami
2015
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2015
Ministerio de Salud
2014-2015
Universidad Nacional Autónoma de México
2003-2011
Objective: Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked cognitive impairment and dementia risk in healthy subjects. Clarifying the impact of attributable medication burden may help optimize outcomes schizophrenia. The aim this study was comprehensively characterize how affects functioning across multiple domains outpatients. Methods: Cross-sectional data were analyzed using inferential statistics exploratory...
Abstract Cognitive impairment is a hallmark of schizophrenia and robust predictor functional outcomes. Impairments are found in all phases the illness only moderately attenuated by currently approved therapeutics. Neurophysiological indices sensory discrimination (ie, mismatch negativity (MMN) P3a amplitudes) gamma-band auditory steady-state response (ASSR; power phase locking) translational biomarkers widely used development novel therapeutics for neuropsychiatric disorders. It unclear...
Abstract Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted cognitive training (TCT) is a “bottom-up” remediation intervention with efficacy for neurocognitive outcomes in schizophrenia, yet individual responses variable. Gamma oscillatory measures leading candidate biomarkers the development biologically informed pro-cognitive therapeutics. Forty-two schizophrenia patients were recruited from long-term residential treatment facility. Participants...
SEE STEPHAN ET AL DOI101093/AWW120 FOR A SCIENTIFIC COMMENTARY ON THIS WORK: Real world information is often abstract, dynamic and imprecise. Deciding if changes represent random fluctuations, or alterations in underlying contexts involve challenging probability estimations. Dysfunction may contribute to erroneous beliefs, such as delusions. Here we examined brain function during inferences about context change from noisy information. We cortical-subcortical circuitry engaging anterior...
Schizophrenia patients exhibit cognitive deficits across multiple domains, including verbal memory, working and executive function, which substantially contribute to psychosocial disability. Gamma oscillations are associated with a wide range of operations, important for cortico-cortical transmission the integration information neural networks. While previous reports have shown that schizophrenia selective impairments in ability support gamma response 40-Hz auditory stimulation, it is...
Chronic psychotic disorders, including schizophrenia (SZ), are highly heterogeneous at many levels of analysis, from genetics to clinical presentation and treatment sensitivity. This heterogeneity reflects both a divergence shared biological pathways moving over hundred “risk genes” different phenotypes, the convergence distinct “phenocopies” chronic psychosis. Successful strategies for developing “next generation” interventions in SZ – “pro-cognitive” medications, cognitive remediation,...
Background: Patients with schizophrenia show abnormal spontaneous oscillatory activity in scalp-level electroencephalographic (EEG) responses across multiple frequency bands. While oscillations play an essential role the transmission of information neural networks, few studies have assessed frequency-specific dynamics cortical source networks at rest. Identification sources and their dynamic interactions may improve our understanding core pathophysiologic abnormalities associated...
Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor untreated subjects with schizophrenia relatives affected subjects. Yet, relation between cognitive impairment its value as a classifier endophenotypes has not been studied.To test efficacy midbrain hyperechogenicity (MHE) parkinsonian (PKM) predictors neurocognitive or at risk for that could be used...
Auditory-based targeted cognitive training (ATCT) programs are emerging pro-cognitive therapeutic interventions which aim to improve auditory processing attenuate impairment in a "bottom up" manner. Biomarkers of early information (EAIP) like mismatch negativity (MMN) and P3a have been used successfully predict gains from full 40 h course ATCT schizophrenia (SZ). Here we investigated the ability EAIP biomarkers performance group subjects (n = 26) across SZ, MDD, PTSD GAD diagnoses. Cognition...
Abstract Schizophrenia patients have widespread deficits in neurocognitive functioning linked to underlying abnormalities gamma oscillations that are readily measured by the 40 Hz auditory steady-state response (ASSR). Emerging interventions such as auditory-based targeted cognitive training (TCT) improve function patients. While acute ASSR changes after 1 hour of TCT predict clinical and gains a 30-hour course TCT, neural substrates short- long-term unknown. To determine TCT-associated...
Abstract Background Auditory frequency modulation learning (‘auditory learning’) is a key component of targeted cognitive training (TCT) for schizophrenia. TCT can be effective in enhancing neurocognition and function schizophrenia, but such gains require significant time effort elude many patients. Methods As strategy to increase and/or accelerate TCT-induced clinical gains, we tested the dose- time-course effects pro-attentional drug, amphetamine (AMPH; placebo, 2.5, 5 or 10 mg po;...