A5010328322- Visual perception and processing mechanisms
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Data Visualization and Analytics
- Alzheimer's disease research and treatments
- Hearing Loss and Rehabilitation
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Neuroscience and Music Perception
- Blood Pressure and Hypertension Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Multisensory perception and integration
- Cholinesterase and Neurodegenerative Diseases
- Noise Effects and Management
- Schizophrenia research and treatment
- Tactile and Sensory Interactions
- Balance, Gait, and Falls Prevention
- Health, Environment, Cognitive Aging
- Cardiovascular Health and Risk Factors
- Scientific Computing and Data Management
- Older Adults Driving Studies
- Glaucoma and retinal disorders
- Computational Drug Discovery Methods
- Transcranial Magnetic Stimulation Studies
- Complex Systems and Time Series Analysis
Posit Science (United States)
2018-2025
University of Iowa
2010-2016
Goucher College
2009
Background: Effective therapeutics for Alzheimer’s disease are needed. However, previous clinical trials have pre-determined a single treatment modality, such as drug candidate or therapeutic procedure, which may be unrelated to the primary drivers of neurodegenerative process. Therefore, increasing data set size include potential contributors cognitive decline each patient, and addressing identified contributors, represent more effective strategy. Objective: To determine whether precision...
We assessed the processing capacity of establishing statistical summary representations (SSRs) mean size in visual displays using simultaneous-sequential method. Four clusters stimuli, each composed several circles with various diameters, were presented around fixation. Observers searched for cluster largest or smallest size. In simultaneous condition, all four concurrently; sequential appeared two at a time. found that SSRs multiple ensembles was as extreme fixed-rate bottleneck process...
Our current understanding of how computerized brain training drives cognitive and functional benefits remains incomplete. This paper describes the protocol for Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE), a randomized controlled trial healthy older adults designed to evaluate whether improves cholinergic signaling.
The simultaneous–sequential method was used to test the processing capacity of statistical summary representations both within and between feature dimensions. Sixteen gratings varied with respect their size orientation. In Experiment 1, were equally divided into four separate smaller sets, one which a mean that larger or than other three orientation tilted more leftward rightward. task report oddball sets. This therefore required for another sets presented at same time in simultaneous...
An ongoing global challenge is managing brain health and understanding how performance changes across the lifespan.
Abstract Importance Effective therapeutics for Alzheimer’s disease and mild cognitive impairment are needed. Objective To determine whether a precision medicine approach to impairment, in which potential contributors decline identified targeted therapeutically, is effective enough proof-of-concept trial warrant larger, randomized, controlled clinical trial. Rationale Previous trials have pre-determined single treatment modality, such as drug candidate or therapeutic procedure, that may be...
Capacity limitations of perceptual surface completion were assessed using a simultaneous-sequential method. Observers searched among multiple surfaces requiring in front other objects (modal completion) or behind (amodal completion). In the simultaneous condition, all presented at once, whereas sequential they appeared subsets 2 time. For both modal and amodal completion, performance was as good condition indicating that unfolds independently for across visual field (i.e., has unlimited...
The visual system can calculate summary statistics over time. For example, the multiple frames of a movie showing dynamically changing disk be collapsed to form single representation that disk's mean size. Summary representations dynamic information may engage online updating processes establish running average by continuously adjusting persisting in tandem with arrival incoming information. Alternatively, involve subsampling strategies reflect limitations degree which integrate Observers...
Adults with cardiovascular disease risk factors (CVRFs) are also at increased of developing cognitive decline and dementia. However, it is often difficult to study the relationships between CVRFs function because assessment typically requires time-consuming in-person neuropsychological evaluations that may not be feasible for real-world situations.We conducted a proof-of-concept determine if association could detected using web-based, self-administered tasks CVRF assessment.We recruited 239...
Click to increase image sizeClick decrease size This research was supported by the National Science Foundation Graduate Research Fellowship awarded M.A. and NSF [grant number BCS-0818536] C.M.M.
Auditory system plasticity is a promising target for neuromodulation, cognitive rehabilitation and therapeutic development in schizophrenia (SZ). Auditory-based targeted training (TCT) 'bottom up' intervention designed to enhance the speed accuracy of auditory information processing, which has been shown improve neurocognition certain SZ patients. However, dynamics TCT learning as function exercises their impact on neurocognitive functioning outcomes are unknown.
<sec> <title>BACKGROUND</title> Our current understanding of how computerized brain training drives cognitive and functional benefits remains incomplete. This paper describes the protocol for Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE), a randomized controlled trial healthy older adults designed to evaluate whether improves cholinergic signaling. </sec> <title>OBJECTIVE</title> INHANCE evaluates 2 programs alter acetylcholine binding using...
ABSTRACT Aging is associated with dysfunction in the cholinergic system, including degeneration of basal forebrain terminals that innervate cortex, which directly contributes to age- and disease-related cognitive decline. In this study, we used [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) positron emission tomography (PET) imaging assess effect age on terminal integrity predefined regions interest its relationship performance healthy older adults who underwent neuropsychological assessment...
We assessed the processing capacity of establishing statistical summary representations mean size in visual displays using simultaneous-sequential method. Experiment 1 tested across multiple ensembles. Four sets stimuli, each composed circles with various diameters, were presented around fixation. The one four was either smaller or larger than that other sets. Observers searched for odd set and reported whether its larger. In simultaneous condition, all concurrently; sequential appeared two...
Abstract Background Cardiovascular risk factors (CVRFs) are linked to cognitive aging. Most studies rely on lengthy in‐person assessments, and it is unclear if web‐based platforms can be used detect the contribution of factors, including CVRFs, aging offering a more pragmatic low cost approach. Method We recruited 239 adults who were enrolled in Health eHeart project order conduct Brain eHealth study, mobile health feasibility study measurement tools age ≥50. CVRFs identified based surveys...
Alzheimer's disease (AD) is a debilitating condition that widely known to adversely affect gray matter (GM) and white (WM) tracts within the brain. Recently, precision medicine has shown promise in alleviating clinical gross morphological trajectories of patients with AD. However, regional changes have not yet been adequately characterized. Investigate responses medicine-guided intervention regards AD mild cognitive impairment (MCI). Clinical neuroimaging data were compiled over 9-month...