A5025278651- Neuroscience and Music Perception
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience of respiration and sleep
- Visual perception and processing mechanisms
- Health, Environment, Cognitive Aging
- Behavioral and Psychological Studies
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Botulinum Toxin and Related Neurological Disorders
- Dermatology and Skin Diseases
- Hypothalamic control of reproductive hormones
- Delphi Technique in Research
- Bipolar Disorder and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
University of California, San Diego
2015-2024
VA San Diego Healthcare System
2017-2023
Dopamine agonists disrupt prepulse inhibition (PPI) of startle in male rodents. In humans, this is observed only some studies. We reported that PPI was disrupted by D: -amphetamine men, but among those with high basal levels. Here, amphetamine effects on were tested normal women and female rats.Acoustic after placebo or 20 mg amphetamine, a double-blind, crossover design, rats vehicle 4.5 mg/kg amphetamine. Rats from Sprague-Dawley (SD) Long Evans (LE) strains differ significantly gene...
Targeted cognitive training (TCT) of auditory processing enhances higher-order cognition in schizophrenia patients. TCT performance gains can be detected after 1 session. As a prelude to potential clinical trial, we assessed pharmacological augmentation therapy (PACT) strategy by testing if the psychostimulant, amphetamine, augments speed (APS) patients and healthy subjects (HS). HS were tested screening session (test 1), followed double-blind crossover design (tests 2–3), comparing placebo...
Objectives Deficient prepulse inhibition (PPI) of startle in schizophrenia patients and unaffected family members may be a useful endophenotype studies seeking to identify vulnerability genes for schizophrenia. Before expanding such include Pacific Rim populations with distinct genetic origins compared North American Caucasian populations, we examined PPI related measures normal Asian men. Methods One hundred seventy-four consecutive carefully screened right-handed male 18–35 year olds...
Failure of procognitive drug trials in schizophrenia may reflect the clinical heterogeneity schizophrenia, underscoring need to identify biomarkers treatment sensitivity. We used an experimental medicine design test effects a putative agent, tolcapone, using electroencephalogram-based cognitive control task healthy subjects.Healthy men and women (n=27; ages 18-35 years), homozygous for either Met/Met or Val/Val rs4680 genotype, received placebo tolcapone 200 mg orally across 2 days separated...
Dopamine D3 receptors regulate sensorimotor gating in rats, as evidenced by changes prepulse inhibition (PPI) of startle after acute administration agonists and antagonists. In this study, we tested the effects D3-preferential agonist, pramipexole, on PPI normal men Sprague-Dawley rats.Acoustic were clinically men, comparing placebo vs. 0.125 mg (n = 20) or 0.1875 double blind, crossover designs. These measures also male rats using a parallel design [vehicle 0.1 mg/kg 8), vehicle 0.3 8) 1.0...