A5002488725- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Consumer Attitudes and Food Labeling
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Nutrition and Health in Aging
- Biochemical Analysis and Sensing Techniques
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Potato Plant Research
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer Risks and Factors
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Microbial Metabolism and Applications
- Sleep and related disorders
- Cystic Fibrosis Research Advances
University of Reading
2019-2024
Sorbonne Paris Cité
2017-2024
Conservatoire National des Arts et Métiers
2022-2024
Université Paris Cité
2017-2024
Centre de Recherche Épidémiologie et Statistique
2017-2024
Université Sorbonne Paris Nord
2018-2024
Inserm
2018-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2017-2024
Sorbonne Université
2021-2024
ParisTech
2024
<h3>Abstract</h3> <h3>Objective</h3> To assess the prospective associations between consumption of ultra-processed food and risk cancer. <h3>Design</h3> Population based cohort study. <h3>Setting participants</h3> 104 980 participants aged at least 18 years (median age 42.8 years) from French NutriNet-Santé (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants’ usual for 3300 different items. These categorised according their...
Abstract Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, sucralose), risk of cardiovascular diseases (overall, coronary heart disease, cerebrovascular disease). Design Population based prospective cohort (2009-21). Setting France, primary prevention research. Participants 103 388 participants web NutriNet-Santé (mean age...
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures food additive risk type 2 diabetes in a large prospective cohort French adults.
Background Emulsifiers are widely used food additives in industrially processed foods to improve texture and enhance shelf-life. Experimental research suggests deleterious effects of emulsifiers on the intestinal microbiota metabolome, leading chronic inflammation increasing susceptibility carcinogenesis. However, human epidemiological evidence investigating their association with cancer is nonexistent. This study aimed assess associations between additive risk a large population-based...
Background: In blood and tissues, dietary endogenously generated fatty acids (FAs) occur in free form or as part of complex lipid molecules that collectively represent the lipidome respective tissue. We assessed associations plasma lipids derived from high-resolution lipidomics with incident cardiometabolic diseases subsequently tested if identified risk-associated were sensitive to fat modification. Methods: The EPIC Potsdam cohort study (European Prospective Investigation into Cancer...
OBJECTIVE To study the relationships between artificial sweeteners, accounting for all dietary sources (total and by type of sweetener) risk 2 diabetes (T2D), in a large-scale prospective cohort. RESEARCH DESIGN AND METHODS The analyses included 105,588 participants from web-based NutriNet-Santé (France, 2009–2022; mean age 42.5 ± 14.6 years, 79.2% women). Repeated 24-h records, including brands commercial names industrial products, merged with qualitative quantitative food additive...
Background Nitrites and nitrates occur naturally in water soil are commonly ingested from drinking dietary sources. They also used as food additives, mainly processed meats, to increase shelf life avoid bacterial growth. Experimental studies suggested both benefits harmful effects of nitrites exposure on type 2 diabetes (T2D) onset, but epidemiological clinical data lacking. We aimed study these associations a large population-based prospective cohort study, distinguishing foods...
Abstract Objective To assess the associations between exposure to food additive emulsifiers and risk of cardiovascular disease (CVD). Design Prospective cohort study. Setting French NutriNet-Santé study, 2009-21. Participants 95 442 adults (>18 years) without prevalent CVD who completed at least three 24 hour dietary records during first two years follow-up. Main outcome measures Associations intake (continuous (mg/day)) CVD, coronary heart disease, cerebrovascular characterised using...
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled intervention trial to construct multilipid score (MLS), summarizing the effects of replacing with on 45 lipid metabolite concentrations. In EPIC-Potsdam cohort, difference in MLS, reflecting better quality, was associated significant reduction incidence cardiovascular (-32%; 95% confidence interval...
Several national and international authorities have proposed nutritional lifestyle recommendations with the aim of improving health general population. Scores adherence to these can be calculated at individual level. Here, we investigated associations between four scores overall, breast, prostate, colorectal cancer risk in a large prospective population-based cohort: cancer-specific World Cancer Research Fund/American Institute for (WCRF/AICR) score, Alternate Healthy Eating Index 2010...
The effects of replacing dietary saturated fatty acids (SFAs) with monounsaturated (MUFAs) and/or polyunsaturated (PUFAs) on the plasma lipidome in relation to cardiometabolic disease (CMD) risk is poorly understood. We aimed assess impact substituting SFAs unsaturated (UFAs) and examine relationship between lipid metabolites modulated by diet CMD risk. Plasma acid (FA) concentrations among 16 classes (within-class FAs) were measured a subgroup from Dietary Intervention VAScular function...
Diverse plant products (e.g. fruits, vegetables, legumes) are associated with decreased cancer risk at several locations while red and processed meat were found to increase risk. A pro plant‐based dietary score reflecting the relative contribution of consumed vs animal was developed, lower overall mortality, type 2 diabetes cardiovascular disease risk, among omnivorous adults. For first time, we investigated prospective associations between this This study included 42,544 men women French...
Serum low density lipoprotein (LDL) cholesterol shows marked interindividual variation in response to the replacement of saturated fatty acids (SFAs) with unsaturated (UFAs). To demonstrate efficacy United Kingdom guidelines for exchanging dietary SFAs UFAs, reduce serum LDL and other cardiovascular disease (CVD) risk factors, identify determinants variability response. Healthy males (n = 109, mean ± SD age 48 11 y; BMI 25.1 3.3 kg/m2), consumed a higher-SFA/lower-UFA diet 4 wk, followed by...
OBJECTIVE The deleterious effects of trans fatty acids (TFAs) on cardiovascular health are well established; however, their impact type 2 diabetes remains poorly understood. In particular, little is known about the specific TFA types etiology. We aimed to explore associations between different TFAs (total, ruminant, industry produced [iTFAs], and corresponding isomers) risk diabetes. RESEARCH DESIGN AND METHODS A total 105,551 participants age &gt;18 years from French NutriNet-Santé...
Abstract Background Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in infants. RSV bronchiolitis associated with an increased risk subsequent wheezing. We aimed to document parents' perception link between infection and wheezing, wheezing‐related healthcare family resources use, its impact on daily life. Methods This cross‐sectional online survey enrolled 1200 parents at least one child ≤6y living United States, Kingdom, Spain, Italy. Children diagnosed before age...
Abstract In France, dairy products contribute to dietary saturated fat intake, of which reduced consumption is often recommended for CVD prevention. Epidemiological evidence on the association between and risk remains unclear, suggesting either null or inverse associations. This study aimed investigate associations (overall specific foods) in a large cohort French adults. prospective analysis included participants aged ≥18 years from NutriNet-Santé (2009–2019). Daily intakes were collected...
Abstract The impact of dairy product consumption for long‐term health remains unclear, in particular regarding their involvement cancer etiology frequent locations like breast or prostate. Besides, little is known about potentially different effects subtypes. Our objective was therefore to evaluate the associations between (total and subtypes) risk. A total 101 279 participants from French NutriNet‐Santé cohort study were included (78.7% women; mean [SD] age = 42.2 [14.5] years). Dairy...
Abstract Purpose UK guidelines recommend dietary saturated fatty acids (SFAs) should not exceed 10% total energy (%TE) for cardiovascular disease prevention, with benefits observed when SFAs are replaced unsaturated (UFAs). This study aimed to assess the efficacy of a exchange model using commercially available foods replace UFAs. Methods Healthy men ( n = 109, age 48, SD 11 year) recruited Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-1 (RISSCI-1) (ClinicalTrials.Gov...
Abstract Background Artificial sweeteners are widely used today by the food industry as sugar alternatives. Potential adverse effects of these additives on cardiovascular disease (CVD) have been suggested in experimental studies, but data from studies involving humans remain very limited. Previous cohorts focused artificially sweetened beverages. Our objective was to study associations between artificial all dietary sources, overall and molecule (aspartame, acesulfame-potassium sucralose),...