A5004772666- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Fungal Plant Pathogen Control
- T-cell and B-cell Immunology
- RNA regulation and disease
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Immunotoxicology and immune responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
- Connective Tissue Growth Factor Research
- Atherosclerosis and Cardiovascular Diseases
- Polyomavirus and related diseases
- Chronic Disease Management Strategies
- Metabolism and Genetic Disorders
- IL-33, ST2, and ILC Pathways
Maastricht University
2023-2025
Maastricht University Medical Centre
2024
University of Amsterdam
1979-2009
Vrije Universiteit Amsterdam
1983-1990
University College London
1987-1989
National Hospital for Neurology and Neurosurgery
1989
's Heeren Loo
1988
The Royal Free Hospital
1987
In a 2 year double blind controlled trial of cyclosporin against placebo in multiple sclerosis conducted at two centres there was beneficial effect the therapy upon progression disease, relapse rate and severity one where patients received mean dose 7.2 mg/kg/day. This not seen other centre lower (mean 5 mg/kg/day) given. Reduction clinical accompanied by decreased IgG synthesis central nervous system. Side effects included hypertension, renal insufficiency anaemia were such to preclude use...
The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator lifestyle environmental influences, positions blood-derived promising tool for early dementia risk detection.
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late-onset Alzheimer′s disease contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances molecular subtyping through proteomic transcriptomic profiling reveal distinct patient subgroups, highlighting complexity beyond amyloid-beta plaques tau tangles. This insight underscores the need expand across new layers, identify novel drug targets for different subgroups. In...
Summary In a recent randomized, double-blind, placebo-controlled crossover trial, we demonstrated efficacy of 4-aminopyridine (4-AP) in improving disability patients with multiple sclerosis (MS). Here describe the relationship between dosage, serum level, efficacy, and safety intravenously orally administered 4-AP same group 70 MS patients. After both intravenous oral administration there was significant levels doses used (p < 0.001 p 0.01, respectively). The use three times day showed large...
<h3>Objective:</h3> To compare the efficacy and toxicity of 4-aminopyridine 3,4-diaminopyridine in patients with multiple sclerosis. <h3>Design:</h3> Intervention study a before-after design randomized, double-blind, crossover design. <h3>Setting:</h3> University referral center. <h3>Patients:</h3> Twenty-four definite sclerosis who had been treated previous clinical trial 4-aminopyridine. <h3>Interventions:</h3> Nonresponders to treatment (14 patients) were 4-week, open-label doses up 1.0...
Abstract Due to its involvement in physiological and pathological processes, histone deacetylase 6 (HDAC6) is considered a promising pharmaceutical target for several neurological manifestations. However, the exact regulatory role of HDAC6 central nervous system (CNS) still not fully understood. Hence, using semi-automated literature screening technique, we systematically collected HDAC6-protein interactions that are experimentally validated reported CNS. The resulting network encompassed...
Magnetic resonance (MR) imaging examinations were performed on a series of seven sets twins (four monozygotic and three dizygotic) one set triplets who clinically discordant for multiple sclerosis (MS). MR abnormalities detected in some the unaffected pairs twins.
The effect of linoleic acid on the electrophoretic mobility red blood cells from both MS patients and normal subjects was studied. An extensive statistical evaluation data clearly demonstrated that there no difference in behaviour presence acid. Even a tendency for erythrocytes to be decreased increased after addition not observable.
In this study, a retrospective comparison was made between 40 patients with an isolated spinal cord syndrome in whom ultimate diagnosis of multiple sclerosis and due to other diseases. The results the study indicate which anamnestic items laboratory findings at time presentation can provide additional support for making individual patient myelopathy without clinical evidence supraspinal lesions.
ABSTRACT INTRODUCTION Given the established association between DNA methylation and pathophysiology of dementia its plausible role as a molecular mediator lifestyle environment, blood-derived data could enable early detection risk. METHODS In conjunction with an extensive array machine learning techniques, we employed whole blood genome-wide surrogate for 14 modifiable non-modifiable factors in assessment risk two independent cohorts Alzheimer’s disease (AD) Parkinson’s (PD). RESULTS We...