A5019473182- Animal Nutrition and Physiology
- Neuroscience and Neural Engineering
- Muscle metabolism and nutrition
- Amyotrophic Lateral Sclerosis Research
- Dietary Effects on Health
- Animal Behavior and Welfare Studies
- Exercise and Physiological Responses
- Body Composition Measurement Techniques
- Thermoregulation and physiological responses
- Rabbits: Nutrition, Reproduction, Health
- Alzheimer's disease research and treatments
- 3D Printing in Biomedical Research
- Conducting polymers and applications
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Livestock and Poultry Management
- Bone and Joint Diseases
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Neurological diseases and metabolism
- Advanced Chemical Sensor Technologies
- Cardiomyopathy and Myosin Studies
- Genetics and Neurodevelopmental Disorders
Linköping University
2015-2024
Karolinska Institutet
1994-2024
Svenska Örtmedicinska Institute
2024
University of British Columbia
2006
Beijing Obstetrics and Gynecology Hospital
2006
Karolinska University Hospital
1994-2005
Swedish University of Agricultural Sciences
1986
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible living systems. The difference between static solid-state and dynamic matter makes seamless integration the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within environment. We demonstrate in vivo electrode formation...
The most common pathology in frontotemporal dementia (FTD) is tau-negative, ubiquitin-immunoreactive (ub-ir) neuronal inclusions (FTLD-U). Recently, we identified mutations the progranulin (PGRN) gene as cause of autosomal dominant FTLD-U linked to chromosome 17. Here, describe neuropathology 13 patients from 6 different families, each with FTD caused by a PGRN mutation. consistent feature was presence ub-ir lentiform intranuclear (NII) neocortex and striatum. In addition, showed...
In Brief OBJECTIVE: This study was initiated to examine pregnancy and neonatal outcomes in women with past or current eating disorders as compared a control group. METHODS: Forty-nine nulliparous nonsmoking previously diagnosed (24 anorexia nervosa, 20 bulimia 5 not otherwise specified) 68 controls were recruited early pregnancy. Data on antenatal complications, mode of delivery, outcome variables collected. For comparisons between groups 1-way analysis variance χ2 test used. RESULTS:...
Over 30 different mutations have now been identified in MAPt that cause frontotemporal dementia (FTD). However, there are several families with FTD show definite linkage to the region on chromosome 17 contains MAPt, which no mutation(s) has identified. Although these could a complex mutation of locus evaded detection it is also possible another gene this associated FTD. This possibility supported by neuropathological findings families, consist neuronal inclusions immunoreactive for ubiquitin...
Twenty‐two female teenagers engaged in elite gymnast training were prospectively studied during a five‐year period and their pubertal development was recorded. Height weight, as well stage of according to Tanner, registered every six months. FSH, LH, TSH prolactin measured girls who had not yet first menstrual period. healthy school the same age group actively physical exercise served control group. Pubertal completed observation all gymnasts but one, primary amenorrhea at eighteen. As...
Summary Vitamin E requirements of adult Standardbred horses were evaluated by tissue depletion and repletion. All the used in study given same basal feed low vitamin during eight months experiment. After an initial period two‐and‐a‐half divided into groups according to amounts DL α‐tocopheryl acetate (0 mg, control; 200, 600, 1800 5400 respectively) as a daily oral supplement. The supplement was followed second period. Total content individual natural tocopherol isomers tocotrienol measured...
Hydrogels are promising materials for medical devices interfacing with neural tissues due to their similar mechanical properties. Traditional hydrogel-based bio-interfaces lack sufficient electrical conductivity, relying on low ionic which limits signal transduction distance. Conducting polymer hydrogels offer enhanced and electronic conductivities biocompatibility but often face challenges in processability require aggressive polymerization methods. Herein, we demonstrate situ enzymatic of...
Twenty‐two female teenagers engaged in elite gymnast training and 22 healthy girls of comparable age were studied with regard to nutritional intake. The mean daily intakes most nutrients both groups accordance the Swedish Nutritional Recommendations; exceptions iron dietary fibre which too low groups. individual variation was large many subjects had an intake below recommendations. Both gymnasts reference group energy significantly estimated need. 725 kcal less than need 450 group. clinical...
Restricted feeding of broiler breeders is required for improved long-term health and welfare. Because frustration hunger are major welfare concerns during rearing, many suggestions have been made to decrease the negative feelings while maintaining suitable growth rates reproductive health. Non-daily ("skip-a-day") schedules commonly used around world increase portion sizes at meal times restricting intake but these practices prohibited in countries due on fasting days. We compared birds...
Intense physical exercise and diet restriction could result in delayed puberty have a negative influence on the acquisition of peak bone mass during puberty. Nineteen young women who had been elite gymnastic training their prepubertal pubertal years were investigated with regard to health, menstrual data mineral areal (BMA). Twenty‐one comparable age served as controls. The menarche “former” gymnasts controls was 14.81.8 12.11.4years, respectively. Fourteen or using oral contraceptives (OCs)...
Objective To characterize endothelial function in postmenopausal former elite athletes comparison to sedentary controls and study the influence of hormone replacement therapy (HRT) on these groups women. Design Cross-sectional study. Setting Research unit at a university hospital. Participants Twenty but still active endurance female 19 age-matched controls. The group control subjects were each subdivided into two basis utilization or non-utilization HRT involving estrogen gestagen. Methods...
The ability to regulate food intake is critical survival. hypothalamus central this regulation, integrating peripheral signals of energy availability. Although our understanding hunger in rodents advanced, an equivalent birds lacking. In particular, the relationship between indices and hypothalamic 'hunger' peptides, agouti-related protein (AgRP), pro-opiomelanocortin (POMC) neuropeptide Y (NPY) poorly understood. Here, we compare AgRP, POMC NPY RNA levels Red Junglefowl chicks raised under...
Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording therapy approach to understand combat neurological disorders. Employing bioelectronic made up of conjugated polymers, which have an innate ability transport both electronic ionic charges, provides the possibility such integration. In particular, translating enzymatically polymerized conductive wires, recently demonstrated in plants simple organism...
Organic chicken production is currently experiencing a boom in Sweden, but has only recently gained access to commercial slow-growing broiler strain, the Rowan Ranger. While these chickens are reported grow at rates better suited organic than previously available strains, anecdotal evidence suggested increased fearfulness this strain and concerns were raised that may deter birds from accessing range. We subjected Rangers fast-growing Ross 308 on same farm set of behavioural tests while also...
Coupling biology with electronics is emerging as a transformative approach in developing advanced medical treatments, examples ranging from implants for treating neurological disorders to biosensors real-time monitoring of physiological parameters. The electrodes used these purposes often face challenges such signal degradation due biofouling and limited biocompatibility, which can lead inaccurate readings tissue damage over time. Conducting organic polymers are promising alternative because...
Objective: To investigate cardiac structure and function exercise capacity in senior former elite athlete women. Design: Cross-sectional study. Participants: Twenty postmenopausal endurance athletes 19 age-matched sedentary controls. Methods: All subjects underwent transthoracic Doppler echocardiography maximal test on a bicycle ergometer. Main Outcome Measures: Cardiac chamber dimensions, wall thickness, function, capacity. Results: The had greater (183 ± 26 vs. 144 36 W; P < 0.01) compared...
Abstract Broiler breeder chickens are commonly reared under strict feed-restriction regimes to reduce obesity-induced health and fertility problems during adult life, assumed experience a reduced welfare due the resulting hunger. In these conditions, feed competition could influence growth rate, so that individuals falling behind in would more stress We hypothesised poor competitors reactive coping style further situation before size-sorting (‘grading’) at four weeks of age. Our results from...
Ketone bodies such as β ‐hydroxybutyrate are important indicators of metabolic condition in birds and linked to a suite ecologically relevant factors including migratory decision‐making, hunger level ectoparasite load. Portable point‐of‐care ( POC ) devices designed measure ketones humans offer cheap easy solution field physiologists comparison with previous laboratory methods; however, their accuracy for use has received scant attention. Here, we assessed the ketone meter (FreeStyle...
Intermittent fasting (IF) is the practice of temporal food restriction to promote metabolic switching between a glucose- and ketone-based metabolism, which has been reported come with diverse health benefits. IF practices appear confer many advantages caloric without restricting total energy intake, studies in both rodents humans suggest organism-wide improvements neurological, cardiovascular health. also commonly employed commercial rearing breeding meat-type poultry, i.e. broiler breeders,...
Intermittent fasting (IF), the implementation of periods at least 12 consecutive hours on a daily to weekly basis, has received lot attention in recent years for imparting life-prolonging and health-promoting effects caloric restriction with no or only moderate actual intake. IF is also widely practiced rearing broiler breeders, parent stock meat-type chickens, who require strict feed regimens prevent serious health problems associated their intense appetites. Although intermittent been...
Uniform growth is a desirable trait in all large-scale animal production systems because it simplifies management and increases profitability. In parental broiler flocks, so-called breeders, low uniformity largely attributed to the feed competition that arises from quantitatively restricted feeding. As restriction crucial maintaining healthy fertile several practices for reducing associated heterogeneity have been suggested range nutrient dilution by increasing fiber content intermittent...