A5067561867- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- Fuel Cells and Related Materials
- Electrochemical sensors and biosensors
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Advanced battery technologies research
- Power Systems and Technologies
- Hydrogen Storage and Materials
- Electrocatalysts for Energy Conversion
- Molecular Communication and Nanonetworks
- Pain Mechanisms and Treatments
- Cephalopods and Marine Biology
- Aerospace Engineering and Energy Systems
- Ammonia Synthesis and Nitrogen Reduction
- Social and Educational Sciences
- Analytical Chemistry and Sensors
- Dendrimers and Hyperbranched Polymers
- Real-time simulation and control systems
- Membrane-based Ion Separation Techniques
- Ion channel regulation and function
- Electrowetting and Microfluidic Technologies
Linköping University
2019-2024
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible living systems. The difference between static solid-state and dynamic matter makes seamless integration the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within environment. We demonstrate in vivo electrode formation...
Abstract Biomimicry at the hardware level is expected to overcome least some of challenges, including high power consumption, large footprint, two‐dimensionality, and limited functionality, which arise as field artificial intelligence matures. One main attributes that allow biological systems thrive successful interpretation response environmental signals. Taking inspiration from these systems, first demonstration using multiple inputs trigger formation control growth an evolvable synaptic...
Future brain-computer interfaces will require local and highly individualized signal processing of fully integrated electronic circuits within the nervous system other living tissue. New devices need to be developed that can receive data from a sensor array, process these into meaningful information, translate information format interpreted by systems. Here, first example interfacing hardware-based pattern classifier with biological nerve is reported. The implements Widrow-Hoff learning...
Organic electronic ion pumps (OEIPs) are versatile tools for electrophoretic delivery of substances with high spatiotemporal resolution. To date, OEIPs and similar iontronic components have been fabricated using thin-film techniques often rely on laborious, multistep photolithographic processes. demonstrated in a variety vitro vivo settings controlling biological systems, but the form factor limited repertoire polyelectrolyte materials device fabrication unnecessarily constrain possibilities...
Vertical organic electrochemical transistor platforms enable facile channel formation by electropolymerization. The improved deposition control and resulting high performance is demonstrated here with the trimer ETE-COONa.
Local and long-lasting administration of potent chemotherapeutics is a promising therapeutic intervention to increase the efficiency chemotherapy hard-to-treat tumors such as most lethal brain tumors, glioblastomas (GBM). However, despite high toxicity for GBM cells, gemcitabine (Gem) cannot be widely implemented they do not efficiently cross blood barrier (BBB). As an alternative method continuous Gem, we here operate freestanding iontronic pumps – "GemIPs" equipped with custom-synthesized...
Hydrogels are promising materials for medical devices interfacing with neural tissues due to their similar mechanical properties. Traditional hydrogel-based bio-interfaces lack sufficient electrical conductivity, relying on low ionic which limits signal transduction distance. Conducting polymer hydrogels offer enhanced and electronic conductivities biocompatibility but often face challenges in processability require aggressive polymerization methods. Herein, we demonstrate situ enzymatic of...
Abstract Organic electrochemical transistors formed by in operando electropolymerization of the semiconducting channel are increasingly becoming recognized as a simple and effective implementation synapses neuromorphic hardware. However, very few studies have reported requirements that must be met to ensure polymer spreads along substrate form functional conducting channel. The nature interface between various monomer precursors polymers through molecular dynamics simulations is...
Green hydrogen is identified as one of the prime clean energy carriers due to its high density and a zero emission CO2. A possible solution for transport H2 in safe low-cost way form liquid organic (LOHCs). As an alternative loading LOHC with via two-step procedure involving preliminary electrolytic production subsequent chemical hydrogenation LOHC, we explore here possibility electrochemical storage (EHS) conversion proton donor into atom involved covalent bonds (R) proton-coupled electron...
The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers explore new diagnostics and therapies for brain disorders. Until now, targeting have mainly relied on biochemical mechanisms, while electrical treatments such as deep stimulation often require invasive procedures. An alternative implanting probes could involve administering molecule precursors intravenously, capable crossing barrier, initiating formation...
We introduce a membrane electrolyzer for the generation of hydrogen peroxide via oxygen reduction and catalyst-free oxidation quinones. The study reports effect applied coulombic forces on ions, which is origin crossover.
Leveraging the biocatalytic machinery of living organisms for fabricating functional bioelectronic interfaces, in vivo, defines a new class micro-biohybrids enabling seamless integration technology with biological systems. Previously, we have demonstrated vivo polymerization conjugated oligomers forming conductors within structures plants. Here, expand this concept by reporting that Hydra, an invertebrate animal, polymerizes oligomer ETE-S both cells expresses peroxidase activity and...
Aqueous organic redox flow battery (AORFB) is a technological route towards the large-scale sustainable energy storage. However, several factors need to be controlled maintain AORFB performance. Prevention of posolyte and negolyte cross-contamination in asymmetric AORFBs, one main causes capacity decay, relies on their membranes' ability prevent migration redox-active species between two electrolytes. The barrier properties are often traded for reduction ionic conductivity which crucial...
Coupling biology with electronics is emerging as a transformative approach in developing advanced medical treatments, examples ranging from implants for treating neurological disorders to biosensors real-time monitoring of physiological parameters. The electrodes used these purposes often face challenges such signal degradation due biofouling and limited biocompatibility, which can lead inaccurate readings tissue damage over time. Conducting organic polymers are promising alternative because...
Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording therapy approach to understand combat neurological disorders. Employing bioelectronic made up of conjugated polymers, which have an innate ability transport both electronic ionic charges, provides the possibility such integration. In particular, translating enzymatically polymerized conductive wires, recently demonstrated in plants simple organism...
Polymer-based ion exchange membranes (IEMs) are utilized for many applications such as in water desalination, energy storage, fuel cells and electrophoretic drug delivery devices, exemplified by the organic electronic pump (OEIP). The bulk of current research is primarily focused on finding highly conductive stable IEM materials. Even though great progress has been made, a lack fundamental understanding how specific polymer properties affect ionic transport capabilities still remains. This...
Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses challenges. While implanted rigid and substrate-bound electrodes often result in inflammation scarring vivo, they outperform situ-formed, more biocompatible by providing superior control over electrode geometry. For example, one of most researched methodologies, formation polymers through enzymatic catalysis is governed diffusion due to slow kinetics, with curing times that span...
In the emerging field of organic bioelectronics, conducting polymers and ion-selective membranes are combined to form resistors, diodes, transistors, circuits that transport process both electronic ionic signals. Such bioelectronics concepts have been explored in delivery devices translate addressing signals into dispensing small charged biomolecules at high specificity spatiotemporal resolution. Manufacturing such "iontronic" generally involves classical thin film processing polyelectrolyte...
Abstract Despite a range of available pain therapies, most patients report so‐called “breakthrough pain.” Coupled with global issues like opioid abuse, there is clear need for advanced therapies and technologies safe effective management. Here the authors demonstrate candidate such an therapy: precise fluid‐flow‐free electrophoretic delivery via organic electronic ion pumps (OEIPs) commonly used anesthetic drug bupivacaine. Bupivacaine delivered to dorsal root ganglion (DRG) neurons in...
The organic electronic ion pump (OEIP) is an on-demand electrophoretic drug delivery device, that via to ionic signal conversion enables without additional pressure or volume changes. fundamental component of OEIPs their polyelectrolyte membranes which are shaped into channels conduct and deliver drugs, with high spatiotemporal resolution. patterning these essential in OEIP devices typically achieved using laborious microprocessing techniques. Here, the development inkjet printable...
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Abstract A novel approach is introduced to modulate the threshold voltage of organic electrochemical transistors (OECTs) that are fabricated by electropolymerizing channel material between source and drain electrodes. To achieve this, we adjust ratio two water‐soluble tri‐thiophene monomers, which share same backbone, but present either anionic or zwitterionic sidechains, during formation. This allows for a continuous modulation both electropolymerization onset potential native doping state...
The dual capability of conductive polymers to conduct ions and electrons, in combination with their flexible mechanical properties, makes them ideal for bioelectronic applications. This study explores the
Abstract Implantable electronically controlled drug delivery devices can provide precision therapeutic treatments by highly spatiotemporally delivery. Iontronic rely on the movement of ions rather than liquid, and therefore achieve in a compact setting without disturbing microenvironment within tissue with fluid flow. For maximum precision, device needs to be closely integrated into tissue, which is challenging due mechanical mismatch between soft harder devices. Here we address this...