A5024258112- Alzheimer's disease research and treatments
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Computational Drug Discovery Methods
- S100 Proteins and Annexins
- Prion Diseases and Protein Misfolding
- Neurological Disease Mechanisms and Treatments
- Neurological Complications and Syndromes
- Multiple Sclerosis Research Studies
- Spondyloarthritis Studies and Treatments
- Streptococcal Infections and Treatments
- Chronic Myeloid Leukemia Treatments
- Protein Tyrosine Phosphatases
- Neuroscience and Neuropharmacology Research
- Vascular Malformations Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Lipoproteins and Cardiovascular Health
- Protein Structure and Dynamics
- Neurological Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neurological diseases and metabolism
- Infectious Encephalopathies and Encephalitis
- Iron Metabolism and Disorders
- IgG4-Related and Inflammatory Diseases
Toranomon Hospital
2023-2024
Okinaka Memorial Adult Disease Research Institute
2023
Japanese Red Cross Medical Center
2009-2013
Maebashi Red Cross Hospital
2004-2007
Gunma University
1995-1999
Tokyo Metropolitan Institute of Medical Science
1995
Tokyo Metropolitan Geriatric Hospital
1993
Abstract To clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42(43) in cerebrospinal fluid (CSF) that accompany normal aging progression Alzheimer's disease (AD), CSF samples 93 AD patients, 32 longitudinal subjects among these 33 patients with non‐AD dementia, 56 other neurological diseases, 54 control from three independent institutes were analyzed by sensitive enzyme‐linked immunosorbent assays. Although tau levels increased aging, a significant elevation correlation...
Abstract Neuroferritinopathy is a hereditary neurodegenerative disorder caused by mutations in the ferritin light chain gene ( FTL1 ). The cardinal features are progressive movement disturbance, hypoferritinemia, and iron deposition brain. To date, five have been described Caucasian Japanese families, but genotype–phenotype correlations remain to be established. We identified novel mutation (exon 4, c.641/642, 4‐nucletotide duplication) family compared clinical traits with those previously...
Abstract Extracellular vesicles (EVs) are membrane that released extracellularly and considered to be implicated in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease. Here, CSF EVs 16 ATN-classified cases were subjected quantitative proteome analysis. In these EVs, levels 11 proteins significantly altered during ATN stage transitions (P < 0.05 fold-change > 2.0). These thought associated with disease represent candidate biomarkers for pathogenic...
Abstract A simple screening test to identify the early stages of Alzheimer’s disease (AD) is urgently needed. We investigated whether odor identification impairment can be used differentiate between A/T/N classification (amyloid, tau, neurodegeneration) in individuals with amnestic mild cognitive or AD and healthy controls. collected data from 132 Japanese participants visiting Toranomon Hospital dementia outpatient clinic. The scores correlated significantly major neuropsychological scores,...
This report describes the case of a 55-year-old woman with varicella-zoster virus (VZV) sacral meningoradiculitis (Elsberg syndrome) who presented herpes zoster in left S2 dermatome area, urinary retention, and constipation. Lumbar magnetic resonance imaging showed nerve root swelling enhancement. Thereafter, she suddenly massive hematochezia hemorrhagic shock because rectal ulcer. To elucidate relation between Elsberg syndrome ulcer, accumulation similar cases is necessary. avoid severe...
To study the role of apolipoprotein E (apoE) in vivo deposits amyloid beta protein (A beta), a major component senile plaque brain patients with Alzheimer disease, transgenic mice were examined by apoE immunostaining. The systemically overexpressing signal peptide and 99 amino acid residues carboxy-terminal fragment human precursor (betaAPP) under control powerful cytomegalovirus enhancer/chicken beta-actin promotor. A appeared at 4 months increased aging acinar cells pancreas. Similarly,...
This report describes the case of a 71-year-old woman with limited form neuromyelitis optica (NMO) who had longitudinally extensive spinal cord lesion from fourth to tenth thoracic vertebrae. Up age 75, she four subsequent recurrences myelitis within same area but no optic neuritis. Anti-AQP4 antibody was seropositive. Recurrence might be characteristic clinical finding in NMO spectrum disorders. For such patients, examination for anti-AQP4 necessary diagnosis and therapy this disorder.
This study aimed to characterize the global cognition and executive functions of older adults with type 1 diabetes mellitus in comparison 2 mellitus.
Abstract The present report describes the case of a 57‐year‐old male patient with spinal dural arteriovenous fistula ( AVF ). During diagnostic examination, intravenous steroid therapy was implemented. next day, patient's symptoms were mildly improved and magnetic resonance imaging showed that cord swelling markedly reduced. After angiographic diagnosis fed from radicular artery originating sixth intercostal artery, shunts surgically interrupted by cutting drainage vein. Clinical...
We report a 26-year-old man with primary refractory nodular sclerosis Hodgkin lymphoma against ABVD, ICE and autologous peripheral blood stem cell transplantation (auto-PBSCT), presenting multiple epidural spinal cord compressions, paraplegia, generalized lymphadenopathy. administrated four cycles of brentuximab vedotin to achieve complete response, then conducted transplantation. This case raises the possibility new strategy for showing residual lesions after auto-PBSCT.
症例は41歳，女性．33歳時に右卵巣奇形腫摘出術の既往あり．性格変化で発症し，不随意運動・痙攣発作が出現し他院より転送された．抗N-methyl-D-aspartate（NMDA）受容体脳炎を疑い，胸腹骨盤造影CTで嚢胞性腫瘍を認めた．両側附属器切除術を施行したが，病理学的に奇形腫はなかった．血漿交換療法で症状は改善した．本症例では8年前に摘出した卵巣奇形腫が発症に関与していた可能性があり，本疾患と卵巣奇形腫の関連についてはさらなる検討が必要である．