A5008713903- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Anesthesia and Sedative Agents
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Anesthesia and Neurotoxicity Research
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Trauma and Emergency Care Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Calpain Protease Function and Regulation
- Electrolyte and hormonal disorders
Kanazawa University Hospital
2016-2025
Kanazawa University
2010-2023
Weatherford College
2022
Industrial Research Institute of Ishikawa
2019
Creative Research Enterprises (United States)
2015
National Institute of Advanced Industrial Science and Technology
2009
Montreal Heart Institute
2003-2004
Université de Montréal
2003-2004
Background: Early initiation of bystander cardiopulmonary resuscitation (CPR) improves the chances successful and survival. The aim present study was to identify attitudes Japanese subjects toward CPR compare them with those observed in previous studies 1998 2006. Methods Results: Participants were asked about their willingness perform 5 different scenarios chest compression (CC) plus mouth-to-mouth ventilation (MMV) versus CC alone. A total 2,785 individuals completed questionnaire,...
Background: Although acute coronary syndrome (ACS) and stroke are known to increase after earthquake, few data exist regarding the effect of earthquake on these cardiovascular events in rural areas. Methods Results: The Noto Peninsula with a magnitude 6.9 occurred at 9:45 a.m. 25 March 2007. first case ACS approximately 15 min later, whereas cerebral hemorrhage (CH) 72 h onset earthquake. During 35 days among 49 patients who were attended by local ambulance, 5 (10.2%) 8 CH (16.3%) documented...
To investigate whether landiolol, an ultra-short-acting β1-antagonist, can safely and effectively control heart rate in septic patients with supraventricular tachyarrhythmias.We reviewed all sepsis who admitted to our intensive care unit between January 2006 December 2011. Sixty one suffered from tachyarrhythmias (heart ≥ 120 bpm for > 1 h). Among 61 patients, 39 were treated landiolol (landiolol group) 22 not (control group). Arterial pressure, rate, cardiac rhythm, pulmonary arterial...
Abstract Background This study aimed to examine factors associated with favourable neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients low-flow time (LFT) exceeding 60 minutes following extracorporeal cardiopulmonary resuscitation (ECPR). Methods was a secondary analysis of the SAVE-J II study, retrospective, multicentre, registry involving 36 participating institutions Japan. OHCA ≥18 years old who underwent ECPR Japan between January, 2013 and December, 2018 were...
<title>Abstract</title> Background As part of family care to prevent PICS-F, it is recommended that restrictions on visitation be relaxed and the environment waiting rooms made more comfortable. The aim this study was investigate current status policies in Japanese ICUs. Methods A nationwide survey across 292 emergency critical centres Japan using a combination postal web-based questionnaires, comprising 12 questions about institutional characteristics, room facilities, policies. Results Of...
Sympathetic activation in chronic heart failure (CHF) is greatly augmented at rest but the response to exercise remains controversial. We previously demonstrated that single-unit muscle sympathetic nerve activity (MSNA) provides a more detailed description of physiological stress than multi-unit recordings. The purpose this study was determine whether reflex and discharge properties MSNA are altered during handgrip (HG, 30% maximum voluntary contraction for 3 min) CHF patients (New York...
Atrial fibrillation (AF) is a common complication in heart failure (HF) patients. However, it remains unclear whether irregular ventricular response patterns induced by AF increase sympathetic nerve activity. We measured resting multi- and single-unit muscle activity (MSNA) 21 age-matched HF patients with chronic (n = 11) rhythm or sinus (SR, n 10). The multi-unit MSNA, which was expressed as total activity, similar between + SR the MSNA significantly greater than that (62 ± 9 spikes min(-1)...
Pharmaceutical agents directed against methicillin-resistant Staphylococcus aureus can be eliminated during haemodiafiltration, not only by diffusion and ultrafiltration, but also adsorption onto haemofilters. The latter may affected the binding of to serum albumin. present study therefore investigated affinity anti-methicillin-resistant (teicoplanin, linezolid, vancomycin) for haemofilters pharmacokinetic properties teicoplanin haemodiafiltration. Linezolid, vancomycin were first screened...
Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk therapeutic failure emergence LZD-resistant strains. However, mechanism drug-drug interaction between is unknown.We conducted a prospective, open-label, uncontrolled clinical study in Japanese patients receiving to evaluate effect coadministered on...
Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports
Background: The unfolded protein response (UPR) plays a pivotal role in ischemia–reperfusion (I/R) injury various organs such as heart, brain, and liver. Sodium 4-phenylbutyrate (PBA) reportedly acts chemical chaperone that reduces UPR. In the present study, we evaluated effect of PBA on reducing UPR protecting against myocardial I/R mice. Methods: Male C57BL/6 mice were subjected to 30-minute I/R, treated with phosphate-buffered saline (as vehicle) or PBA. Results: At 4 hours after...
We herein present our experience with a case involving 17-year-old Japanese boy suffering from acute myocarditis after his second coronavirus disease-2019 (COVID-19) messenger RNA (mRNA) vaccine shot. The patients had history of associated Campylobacter jejuni 3 years prior. This has been the first-ever documented COVID-19 mRNA vaccination in patient myocarditis. series images and blood biomarkers for different types that developed this single patient.
To assess the impact of 2020 coronavirus disease (COVID-19) pandemic on prehospital characteristics and outcomes out-of-hospital cardiac arrest (OHCA) in elderly.In this population-based nationwide observational study Japan, 563,100 emergency medical service-unwitnessed OHCAs elderly (≥65 years) patients involving any resuscitation efforts were analysed (144,756, 140,741, 140,610, 136,993 cases 2020, 2019, 2018, 2017, respectively). The epidemiology, characteristics, associated with compared...
Background Some patients with COVID-19 experienced sudden death due to rapid symptom deterioration. Thus, it is important predict exacerbation at an early stage prior increasing severity in patients. Patients could experience a unique “silent hypoxia” of the infection when they are apparently asymptomatic, but rather low SpO2 (oxygen saturation) levels. In order continuously monitor daily life, high-performance wearable device, such as Apple Watch or Fitbit, has become commercially available...
Background It has been reported that sympathetic nerve activity (SNA) is associated with fibrinolysis, but the interaction between SNA and fibrinolytic system aging not elucidated in humans. The purpose of this study was to examine effect age-related on plasminogen activator inhibitor type 1 (PAI-1) tissue (tPA) using muscle (MSNA). Methods Results This included 16 young subjects (mean age 26.1 years) 10 aged 56.9 years). Lower body negative pressure (LBNP) performed at -40 mmHg for 30 min....
Acute liver failure (ALF) is a critical illness with high mortality. Plasma diafiltration (PDF) blood purification therapy that useful for ALF patients, but it difficult to use when those patients have multiple organ or unstable hemodynamics. In these symptoms are also likely exacerbate immediately after PDF therapy. We developed continuous (CPDF) as new concept in therapy, and assessed its efficacy safety patients.Ten (gender: M/F 6/4, Age: 47 ± 14) were employed CPDF The primary outcomes...
Abstract Background Caffeine is a widely used dietary stimulant, and cases of caffeine overdoses, sometimes leading to death, are increasing. We encountered case intoxication resolved with administration the sedative agent dexmedetomidine. Case presentation administered dexmedetomidine for sedation suppress sympathetic nerve stimulation in an 18-year-old Japanese male who ingested massive dose intention committing suicide. The patient was excited state had hypertension, sinus tachycardia,...
Background The number of the elderly patients with atrial fibrillation (AF) is increasing, but current status anticoagulation therapy for AF in Japan not clear. Methods and Results Among registered "Hokuriku Atrial Fibrillation Trial (HAT) 1", 365 aged ≥65 years were enrolled this study. Warfarin was used significantly less oldest group ≥85 (36%) than younger populations, percentage antiplatelet use population largest (40%). (≥85 years) compared a between 75 84 years. given to 61% 36% group....
Acute coronary syndrome is sometimes accompanied by accelerated coagulability, lipid metabolism, and inflammatory responses, which are not attributable to the cardiac events alone. We hypothesized that liver plays a pivotal role in pathophysiology of acute syndrome. simultaneously analyzed gene expression profiles heart during myocardial ischemia mice.-Mice were divided into 3 treatment groups: sham operation, ischemia/reperfusion, infarction. Mice with ischemia/reperfusion included as...