A5101406607- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Airway Management and Intubation Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Thermal Regulation in Medicine
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Blood transfusion and management
- Cardiac and Coronary Surgery Techniques
- Sepsis Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Intraoperative Neuromonitoring and Anesthetic Effects
- Voice and Speech Disorders
- Intensive Care Unit Cognitive Disorders
- Aortic Disease and Treatment Approaches
- Obstructive Sleep Apnea Research
- Alzheimer's disease research and treatments
- Tracheal and airway disorders
- Thermoregulation and physiological responses
- Dupuytren's Contracture and Treatments
Hamamatsu University School of Medicine
2016-2025
Hamamatsu University
2022-2023
Tokushima University
2022-2023
Hamamatsu University Hospital
2023
Beijing Friendship Hospital
2022
Capital Medical University
2022
Kyoto University
1990
Kawashima, Shingo MD, PhD; Kimura, Tetsuro Kinoshita, Hiroyuki PhD Author Information
Remimazolam is a novel ultrashort-acting benzodiazepine that has recently become available for general anesthesia. However, the incidence of postoperative nausea and vomiting (PONV) associated with remimazolam remains unknown. In this propensity score-matched, retrospective, observational study, we compared rates PONV between propofol.In retrospective score-matching was performed to minimize selection bias. Patients who received total intravenous anesthesia or propofol at Hamamatsu...
Abstract Background Andexanet alfa, an anti-Xa inhibitor antagonist, induces heparin resistance. Here, we report a case of successful management cardiopulmonary bypass with andexanet alfa-induced resistance using nafamostat mesylate. Case presentation An 84-year-old female, Stanford type A acute aortic dissection, underwent emergency surgery for total arch replacement. alfa 400 mg was administered preoperatively to antagonize edoxaban, oral Xa inhibitor. Heparin 300 IU/kg before bypass, and...
Fibrinogen and fibrin formation have a key role in perioperative hemostasis. The aim of this study is to examine the association postoperative hemostasis with combined evaluation fibrinogen level polymerization cardiac surgery. We retrospectively classified 215 consecutive surgery patients into 4 groups (Fuji-san classification) that were divided by <150 mg/dL (ie, hypofibrinogenemia) thromboelastometry value at 10 minutes rotational <6 mm low polymerization) warming cardiopulmonary bypass....
A decrease in heart rate (HR) using a short-acting β blocker has potential benefits sepsis; however, depression of hemodynamics and reduction cerebral oxygenation may also occur endotoxemia.Seventeen swine were allocated to landiolol or control groups. In the group, dose was sequentially changed from 0 40 200 μg kg min, stopped. Hemodynamics, blood variables, tissue index (TOI) recorded by near infrared spectroscopy at each dose. Lipopolysaccharide (LPS) then administered continuously 1 h...
Few studies have investigated spinal cord autoregulation using near-infrared spectroscopy (NIRS). Here, we assessed under normal, hypovolemic, and post-fluid resuscitation conditions compared with cerebral autoregulation.Ten pigs (36.1 ± 1.1 kg) were anesthetized 2.5% isoflurane, before phenylephrine administration at 0.5, 1, 2, 5 μg kg-1 min-1 in a stepwise fashion 10-min intervals (baseline), followed by similar of sodium nitroprusside (SNP). Hypovolemia was induced 600-ml bleed (25%...
We developed a new assay for plasma or serum G4 acetylcholinesterase (AChE) activity. There was no difference in AChE activity between and plasma. Plasma control subjects (8–92 years) independent of age. Serum significantly increased patients with vascular dementia (P < 0·01), compared age-matched control, decreased those probable Alzheimer-type 0·02). The VD ATD significant 0·001), thus the measurement would be helpful differential diagnosis dementia.
BACKGROUND The impact of blood pressure changes on tissue oxygenation differs between vital organs and with volume conditions. OBJECTIVE To assess cerebral renal autoregulation simultaneously compare the pressure, hypovolaemia fluid resuscitation using near-infrared spectroscopy. DESIGN Animal observational study. SETTING An animal laboratory in Hamamatsu University School Medicine, Hamamatsu, Japan, from April 2018 to August 2018. ANIMALS Fifteen pigs, (mean ± SD) 25.2 0.4 kg. INTERVENTIONS...
ABSTRACT Background: High-dose vasopressors maintain blood pressure during septic shock but may adversely reduce microcirculation in vital organs. We assessed the effect of high-dose norepinephrine and vasopressin on brain, tongue, liver, kidney endotoxic using near-infrared spectroscopy (NIRS). Methods: Thirteen pigs (24.5 ± 1.8 kg) were anesthetized, an NIRS probe was attached directly to each organ. Approximately 0.2, 0.5, 1, 2 μg/kg/min administered a stepwise manner, followed by 2, 5...
Patients with a brain tumor are susceptible to the hypnotic effect of anesthetics depending on tumor's size. We investigated whether intracranial space-occupying lesions (ICSOLs) inducing hypertension increase isoflurane's electroencephalographic (EEG) results.After anesthetic induction isoflurane, 11 swine were studied regard EEGs at 0.5% 2.0% inhalational concentration sequential stages: baseline 1, ICSOL 2, 3. At each stage, an epidural balloon catheter was inflated and pressure...
Core temperature is important for the safety of patients in ICU. Although blood (Tbl) has been accepted as gold standard core monitoring, it requires an invasive procedure. A recently developed new thermometer, SpotOn®(3M, St. Paul, MN) that measures deep-forehead (Tdf) can measure during surgery1) a noninvasive manner. However, its accuracy ICU not known.
Abstract Aims Cardiopulmonary bypass (CPB) reduces the plasma protein‐binding rate of some anaesthetics and can enhance their pharmacological effects by increasing unbound drug fraction. However, whether these changes occur with remifentanil remains to be explored. We investigated in during CPB compared propofol. Methods Thirteen patients (≥18 years old) who were scheduled undergo cardiovascular surgery included. Arterial blood samples collected measure concentrations propofol before (T1),...