A5101908629- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Amyotrophic Lateral Sclerosis Research
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- RNA regulation and disease
- Pharmacological Receptor Mechanisms and Effects
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- Cardiovascular Function and Risk Factors
- Synthetic Organic Chemistry Methods
- Autophagy in Disease and Therapy
- GABA and Rice Research
- Cholinesterase and Neurodegenerative Diseases
- Trace Elements in Health
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Coronary Interventions and Diagnostics
- Prion Diseases and Protein Misfolding
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Garlic and Onion Studies
Toyokawa City Hospital
2004-2023
Yokohama University of Pharmacy
2020-2022
Nihon University
2011-2020
Nihon Pharmaceutical University
2019-2020
Yokohama City University
2019
Niigata University
2017
Sanden (Japan)
2015
Yamagata University
2012
Nihon University Itabashi Hospital
2009
Asahikawa Medical College Hospital
2001-2007
A link between circadian rhythm and metabolism has long been discussed. Circadian is controlled by positive negative transcriptional translational feedback loops composed of several clock genes. Among genes, the brain muscle Arnt-like protein-1 (BMAL1) locomotor output cycles kaput (CLOCK) play important roles in regulation rhythmic transcription. In addition to control rhythm, we have previously shown that BMAL1 regulates adipogenesis. metabolic syndrome patients, function dysregulated...
Asthma is characterised by chronic inflammation of the airways, but relevance high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker low-grade systemic inflammation, has not been fully studied in asthma. The objective was examine serum hs-CRP levels patients with asthma and their relationship clinical characteristics degree airway inflammation. Serum were cross-sectionally examined steroid-naive (n = 22) steroid-inhaling 23) adult healthy controls...
Six chalcones from Angelica keiskei KOIDZUMI (Ashitaba in Japanese) and two Humulus lupulus L. (hop) were examined for their cytotoxicity human neuroblastoma cell lines (IMR-32 NB-39) normal cells (primary culture of rat cerebellar granule cells) by [3-(4,5)-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. All exhibited against cells, them (isobavachalcone xanthoangelol H) had no effect on even at high concentration (10−4 m) exposure. Typical morphologic features...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons. Recent studies have implicated that chronic hypoxia and insufficient vascular endothelial growth factor (VEGF)-dependent neuroprotection may lead to degeneration neurons in ALS. Expression apelin, an endogenous ligand for G protein-coupled receptor APJ, regulated hypoxia. In addition, recent reports suggest apelin protects against glutamate-induced excitotoxicity. Here, we...
Abstract: In primary cultures of mouse cerebellar granule cells, a brief stimulation by γ‐hydroxybutyric acid (GHB, 0.1–3 m M ) significantly increased the intracellular Ca 2+ concentration ([Ca ] i in concentration‐dependent manner. addition, gel mobility assay showed that exposure cells to GHB also nuclear DNA‐binding activity specific for cyclic AMP‐responsive element (CRE) and activator protein 1 (AP‐1) transcriptional The range was essentially same as elicited increase [Ca . GHB‐induced...
BACKGROUND: C-reactive protein (CRP) is an acute phase reactant, and has been reported as a predictor of cardiovascular diseases. Measurements high sensitive CRP in thawed samples are possible the values thought to remain stable even after frozen storage. However, long-term stability not documented. We measured before storage, examined difference determined values.METHODS: High was storage from 99 men women among JMS Cohort Study subjects. selected subjects who underwent measurement at...
Abstract The effect of intrastriatal microinjection kainic acid (KA) on specific binding [ 3 H]muscimol to the particulate fractions obtained from corpus striatum (CS), globus pallidus (GP), substantia nigra (SN), and cerebral cortex (CC) was examined. Seven days after unilateral KA, amount specifically bound significantly increased at injected site, whereas no significant alteration found in GP, SN, or CC. Scatchard analysis striatal revealed that KA affinity ( K D ) GABA receptors...