A5035302071- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Ion Channels and Receptors
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Advanced Chemical Sensor Technologies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastroesophageal reflux and treatments
- Nasal Surgery and Airway Studies
- Voice and Speech Disorders
- Indoor Air Quality and Microbial Exposure
- Infant Health and Development
- Noise Effects and Management
- Inhalation and Respiratory Drug Delivery
- Circadian rhythm and melatonin
- Dysphagia Assessment and Management
- Health and Well-being Studies
- Sinusitis and nasal conditions
- Diet and metabolism studies
- Health, psychology, and well-being
- Neurobiology and Insect Physiology Research
- Thermoregulation and physiological responses
- Urban Green Space and Health
Sahlgrenska University Hospital
2008-2024
University of Gothenburg
2013-2024
Region Västra Götaland
2024
Swedish Asthma and Allergy Association
1987-2016
Swedish Research Council
2016
Umeå University
2016
Swedish University of Agricultural Sciences
2016
University of Gävle
2016
Swedish Academy
2015
Hull York Medical School
2013
These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of hypersensitivity has allowed an umbrella term that explains exquisite sensitivity patients to external stimuli such a cold air, perfumes, smoke bleach. Thus, adults with now have firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist variant asthma (CVA)/eosinophilic bronchitis responding anti-inflammatory...
In 2011, a European Respiratory Society Task Force embarked on process to determine the position and clinical relevance of cough hypersensitivity syndrome, disorder characterised by troublesome coughing often triggered low levels thermal, mechanical or chemical exposure, in management patients with chronic cough. A 21-component questionnaire was developed an iterative supported literature review. 44 key opinion leaders respiratory medicine were selected interviewed as their opinions. There...
Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we reviewed the age and sex unselected referrals to 11 clinics. To investigate cause any observed dimorphism, functional magnetic resonance imaging putative was analysed in normal volunteers. The demographic profile consecutive patients presenting evaluated. Cough challenge capsaicin undertaken volunteers construct concentration-response curve....
Background Investigations of patients referred for suspected asthma have revealed a little‐known group with symptoms suggesting hyperreactive airways in whom provocation methacholine does not lead to bronchial obstruction. The underlying mechanisms are known, and no objective diagnostic method has been available. Methods Provocations by inhalation capsaicin solutions stepwise increasing concentrations were used. Ten asthma‐like after exposure nonspecific irritating stimuli, but without...
Asthma and allergy are stressful conditions that require coping strategies social support to reduce stress enhance health-promoting behavior. However, research is limited regarding in asthma allergy. The aim was better understand the use of different perceived low high severity (exacerbation frequency) allergy.Population-based data were used provide ratings (Study I) II) from 124 94 participants, respectively, with and/or allergy, categorized as or severity. Problem- emotion-focused assessed...
Chronic unexplained cough triggered by environmental irritants is characterized increased reflex sensitivity, which can be demonstrated means of inhaled capsaicin. Topical capsaicin used to improve non-allergic rhinitis and intestinal hypersensitivity reduce neuropathic pain.We established whether an oral intake natural (chilli) could desensitize the coughing.Twenty-four patients with irritant-induced, chronic 15 controls were included in study. For 4 weeks, participants took capsules pure...
A group of patients with asthma-like symptoms and sensitivity to chemical irritants, but without bronchial obstruction, has been found among subjects referred for suspected asthma. They have no well-defined diagnosis, objective diagnostic method previously available. These are more sensitive inhaled capsaicin than asthma or healthy controls. The aim was study cough other capsaicin-induced test the effect a drug (lidocaine) that inhibits nerve transmission in sensory nerves.Twelve were...
A group of nine patients with respiratory symptoms after nonspecific irritating stimuli, but without any IgE-mediated allergy or demonstrable bronchial obstruction, were referred to the asthma/allergy outpatient department for evaluation suspected asthma. In order find a provocation model and objectively assess these patients' in controlled studies, perfume placebo was performed. The same also subjected carbon filter mask ascertain whether breathing through active could prevent symptoms....
Objective: To develop, evaluate, and apply a questionnaire-based instrument for investigation of specific symptoms in idiopathic environmental intolerance (IEI), called the Idiopathic Environmental Intolerance Symptom Inventory (IEISI). Methods: Participants with IEI to chemicals responded 82 candidate three subscales Quick Exposure Sensitivity (QEESI) at test (n = 207) retest 193) occasion. Results: The 27 most commonly reported were selected grouped into five symptom categories. Internal...
Current guidelines on the management of chronic cough do not provide recommendations for operation specialist clinics. The objective present study was to develop expert consensus goals and standard procedures clinics.We undertook a modified Delphi process, whereby initial statements proposed by experts were categorised presented back panellists over two ranking rounds using an 11-point Likert scale identify consensus.An international panel 57 from 19 countries participated, with reached 15...
Reference values for acoustic rhinometry are presented from 334 individuals without nasal symptoms between 4 years and 61 old. There was a significant correlation the minimal cross-sectional area (MCA) volume. Although reproducibility of method good, MCA varied widely. correlated weakly to weight, height, age, body mass index. Our data suggest that is valuable inter-individual comparisons.
It is common in asthma and allergy clinics to see patients presenting with upper lower airway symptoms that are induced by chemicals scents not explained allergic or asthmatic reactions. Previous studies have shown these often increased cough sensitivity inhaled capsaicin; such known reflect the sensory reactivity. The aim of this study was evaluate duration measure health-related quality life (HRQL) chemically symptoms. We also wished determine compare repeatability response capsaicin...
Background: Capsaicin, the pungent ingredient in red pepper, is known to stimulate coughing via sensory nervous system. Earlier studies showed that patients with airway symptoms induced by chemicals and strong scents cough more after inhalation of capsaicin than healthy control subjects this has been interpreted as a hyperreactivity nerves. Our aim was study sensitivity inhaled occurrence who underwent bronchial methacholine test, primarily because suspected asthma. Methods: Fifty‐two...
Patients complaining of upper and lower airway symptoms caused by scents chemicals have previously been shown to increased cough sensitivity inhaled capsaicin, but the precise mechanisms behind this reaction are unknown. Hypothesizing that a neurochemical alteration related sensory hyperreactivity (SHR) mucosa occurs, we measured levels nerve growth factor (NGF) in nasal lavage fluid (NAL) before after capsaicin inhalation provocations NGF levels. Thirteen patients with SHR 14 control...