A5036048022- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Quantum, superfluid, helium dynamics
- Medical Imaging Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nuclear Physics and Applications
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Thermal Regulation in Medicine
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Superconducting Materials and Applications
- Inhalation and Respiratory Drug Delivery
- Ultrasound and Hyperthermia Applications
- Advanced Neuroimaging Techniques and Applications
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- MRI in cancer diagnosis
- Radiation Detection and Scintillator Technologies
- Respiratory viral infections research
University of Sheffield
2016-2025
Insigneo
2023-2025
Canadian Respiratory Research Network
2023
Royal Hallamshire Hospital
2015-2022
Institute of Infection and Immunity
2022
St. Vincent's University Hospital
2019
Southampton Children's Hospital
2019
Aarhus University Hospital
2018
Novartis (Switzerland)
2017
Jagiellonian University
2011-2013
Background SARS-CoV-2 targets angiotensin-converting enzyme 2–expressing cells in the respiratory tract. There are reports of breathlessness patients many months after infection. Purpose To determine whether hyperpolarized xenon 129 MRI (XeMRI) imaging could be used to identify possible cause at 3 hospital discharge following COVID-19 Materials and Methods This prospective study was undertaken between August December 2020, with healthy control volunteers being enrolled. All underwent lung...
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19) lung fibrosis suggest severe acute respiratory syndrome 2 (SARS-CoV-2) infection may lead to progressive damage. Objectives: The UK Interstitial Lung Disease Consortium (UKILD) post–COVID-19 study interim analysis was planned estimate the prevalence of residual abnormalities in people hospitalized with COVID-19 on basis risk strata. Methods: PHOSP–COVID-19 (Post-Hospitalization COVID-19) used capture...
Background Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. Purpose To determine if previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 (129Xe) MRI scans in participants with post-COVID-19 who were hospitalized also present not hospitalized. Materials and Methods In this prospective study, nonhospitalized (NHLC)...
Hyperpolarized (HP) 129 Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly safely, providing novel information not possible using conventional imaging modalities or function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP as outcome measures multi-site clinical trials across a range disorders. Until recently, techniques have been developed largely independently at limited number academic centers,...
Here we present a $\mathrm{Rb}\text{\ensuremath{-}}^{129}\mathrm{Xe}$ spin-exchange optical pumping polarizer capable of rapid generation large volumes highly polarized $^{129}\mathrm{Xe}$ gas. Through modeling and measurements maximize the nuclear spin polarization output to enable gas imaging ($300\text{ }\text{ }{\mathrm{cm}}^{3}$) every 5 min within clinical setting. Our model is verified by experiment correctly predict optimum Rb vapor density for maximum flux $3.4\text{...
Background To support translational lung MRI research with hyperpolarized 129 Xe gas, comprehensive evaluation of derived quantitative function measures against established from 3 He is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability functional metrics not reported. Purpose/Hypothesis compare MRI‐derived ventilation microstructure, their repeatability, 1.5T. Study Type Retrospective. Population Fourteen healthy nonsmokers (HN), five...
The COVID-19 pandemic has led to over 100 million cases worldwide. UK had 4 cases, 400 000 hospital admissions and deaths. Many patients with suffer long-term symptoms, predominantly breathlessness fatigue whether hospitalised or not. Early data suggest potentially severe consequence of is development long COVID-19-related interstitial lung disease (LC-ILD).
Microvascular abnormalities and impaired gas transfer have been observed in patients with COVID-19. The progression of pulmonary changes these remains unclear.
Abstract Purpose To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group healthy volunteers. Methods Sixty‐five subjects with no history chronic disease were assessed 129 using four‐echo 3D radial spectroscopic imaging sequence dose xenon titrated according to subject height that was inhaled from functional residual capacity (FRC). Imaging repeated 34 at total (TLC). Regional maps fractions dissolved red blood cells (RBC), membrane (M),...
Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange IPF lungs. In population patients with IPF, we find that the signal from red blood cells diminishes relative tissue/plasma over 12-month time period, even when diffusion factor for carbon monoxide static same period. We conclude 129Xe MR be short-term...
Hyperpolarised helium-3 ( 3 He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF severity patient age, as well assess the effect inhaled volume on distribution. 32 children adults with underwent MBW He-MRI at end-inspiratory tidal (EI V T ). In addition, 28 patients performed total capacity. scans were quantitatively...
Purpose To obtain whole lung morphometry measurements from 129 Xe in a single breath‐hold with 3D multiple b‐value diffusion‐weighted MRI (DW‐MRI) an empirically optimized diffusion time and compressed sensing for scan acceleration. Methods Prospective three‐fold undersampled hyperpolarized DW‐MRI datasets were acquired, the (Δ) was iterated so as to provide diffusive length scale (Lm D ) estimates stretched exponential model (SEM) that are comparable those 3 He. The then implemented...
Purpose To demonstrate three‐dimensional (3D) multiple b ‐value diffusion‐weighted (DW) MRI of hyperpolarized 3 He gas for whole lung morphometry with compressed sensing (CS). Methods A fully‐sampled, two ‐value, 3D DW‐MRI dataset was acquired from the lungs a healthy volunteer and retrospectively undersampled in k y z phase‐encoding directions CS simulations. Optimal k‐space undersampling patterns were determined by minimizing mean absolute error between reconstructed fully‐sampled apparent...
To evaluate the reproducibility of indices lung microstructure and function derived from 129 Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers patients with chronic obstructive pulmonary disease (COPD), to study sensitivity CSSR-derived parameters pulse sequence design inflation level.Preliminary data were collected five on three occasions, using two implementations CSSR sequence. Separately, each underwent at different levels. After analysis these preliminary...
Purpose To develop an image‐processing pipeline for semiautomated (SA) and reproducible analysis of hyperpolarized gas lung ventilation proton anatomical magnetic resonance imaging (MRI) scan pairs. compare results from the software total volume (TLV), ventilated (VV), percentage (%VV) calculation to current manual “basic” method a K‐means segmentation method. Materials Methods Six patients were imaged with 3 He same‐breath 1 H MRI at 1.5T six other scanned 129 Xe separate‐breath MRI. One...
In this study, the effect of lung volume on quantitative measures ventilation was investigated using MRI with hyperpolarized 3 He and 129 Xe. Six volunteers were imaged at five different volumes [residual (RV), RV + 1 liter (1L), functional residual capacity (FRC), FRC 1L, total (TLC)], three also Imaging each repeated twice same day corresponding H anatomical images. Percent ventilated (%VV) variation signal intensity [heterogeneity score (H )] evaluated. Increased heterogeneity, quantified...
Purpose Imaging of the different resonances dissolved hyperpolarized xenon‐129 ( 129 Xe) in lung is performed using a four‐echo flyback 3D radial spectroscopic imaging technique and evaluated healthy volunteers (HV) subjects with idiopathic pulmonary fibrosis (IPF). Theory Methods 10 HV 25 IPF underwent Xe MRI at 1.5T. same day function tests to measure forced vital capacity diffusion for carbon monoxide (DL CO ). A four‐point echo time k‐space chemical‐shift modeling gas, tissue/plasma (TP)...
Background Free‐breathing 1 H ventilation MRI shows promise but only single‐center validation has yet been performed against methods which directly image lung in patients with cystic fibrosis (CF). Purpose To investigate the relationship between 129 Xe and images using data acquired at two centers. Study type Sequence comparison. Population Center 1; 24 CF (12 female) aged 9–47 years. 2; 7 (6 13–18 years, 6 healthy controls 21–31 Data were different each center. Field Strength/Sequence 1.5...
ABSTRACT MR imaging holds the potential to enhance drug development efficiency by de‐risking early phase studies and increasing confidence in results. It can improve patient selection, increase repeatability, provide greater sensitivity change, thereby enabling smaller, faster clinical trials. For trials pulmonary space, hyperpolarized 129 Xe MRI is appealing because it provides 3‐dimensional of ventilation gas exchange a brief, non‐invasive exam. Metrics derived from may be more sensitive...
Preterm birth is associated with low lung function in childhood, but little known about the microstructure childhood.
Respiratory diseases are leading causes of mortality and morbidity worldwide. Pulmonary imaging is an essential component the diagnosis, treatment planning, monitoring, assessment respiratory diseases. Insights into numerous pulmonary pathologies can be gleaned from functional lung MRI techniques. These include hyperpolarized gas ventilation MRI, which enables visualization quantification regional with high spatial resolution. Segmentation ventilated required to calculate clinically relevant...