A5091680861- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Medical Imaging Techniques and Applications
- Congenital Heart Disease Studies
- Thermal Regulation in Medicine
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Ultrasound and Hyperthermia Applications
- Neonatal Respiratory Health Research
- Quantum, superfluid, helium dynamics
- Nuclear Physics and Applications
- Medical Imaging and Pathology Studies
- Vascular Anomalies and Treatments
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Superconducting Materials and Applications
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
University of Sheffield
2015-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2013-2024
Canadian Respiratory Research Network
2023
Institute of Infection and Immunity
2022
Royal Hallamshire Hospital
2006-2020
Cliniques Universitaires Saint-Luc
2017
King's College London
2017
National Heart Lung and Blood Institute
2016
Pulmonary hypertension (PH) is a heterogeneous condition. To date, no registry data exists reflecting the spectrum of disease across five diagnostic groups encountered in specialist referral centre. Data was retrieved for consecutive, treatment-naïve cases diagnosed between 2001 and 2010 using catheter-based approach. 1,344 patients were enrolled, with mean follow-up 2.9 yrs. The 3-yr survival 68% pulmonary arterial (PAH), 73% PH associated left heart disease, 44% lung (PH-lung), 71% chronic...
Rationale: Prognostication is important when counseling patients and defining treatment strategies in pulmonary arterial hypertension (PAH).Objectives: To determine the value of magnetic resonance imaging (MRI) metrics for prediction mortality PAH.Methods: Consecutive with PAH undergoing MRI were identified from ASPIRE (Assessing Spectrum Pulmonary Hypertension Identified at a Referral Centre) registry.Measurements Main Results: During follow-up period 42 (range, 17–142) months 576 studied...
Cardiovascular Magnetic Resonance (CMR) imaging is accurate and reproducible for the assessment of right ventricular (RV) morphology function. However, diagnostic accuracy CMR derived RV measurements detection pulmonary hypertension (PH) in patients with suspected PH clinic setting not well described. We retrospectively studied 233 consecutive treatment naïve including 39 no who underwent heart catheterisation (RHC) within 48hours. The multiple mPAP ≥ 25 mmHg was assessed using Fisher's...
Rationale: Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and Respiratory the REVEAL (North American Registry to Evaluate Early Long-Term PAH Disease Management) risk score calculator (REVEAL 2.0) identify thresholds predict 1-year mortality.Objectives: This study evaluates whether cardiac magnetic resonance imaging (MRI) can be identified used aid stratification facilitate decision-making.Methods: Consecutive patients with (n = 438)...
The aim of this study was to evaluate the clinical use magnetic resonance imaging measurements related pulmonary artery stiffness in evaluation hypertension (PH).A total 134 patients with suspected PH underwent right heart catheterization (RHC) and on a 1.5-T scanner within 2 days. Phase contrast at trunk cine cardiac views were acquired. Pulmonary area change (AC), relative AC (RAC), compliance (AC/pulse pressure from RHC), distensibility (RAC/pulse ventricular functional indices, mass all...
There are limited data on the prognostic value of cardiovascular magnetic resonance measurements in idiopathic pulmonary arterial hypertension, with no studies investigating impact correction indices for age and sex value.Consecutive patients hypertension underwent imaging at 1.5T. Steady-state free precession cardiac volumes mass were corrected age, sex, body surface area according to reference significance assessed. A total 80 identified, 23 died during mean follow-up 32±14 months....
Objective. Pulmonary arterial hypertension (PAH) is a life-threatening complication of connective tissue diseases (CTD). Our aim was to compare the diagnostic utility noninvasive imaging modalities, i.e., magnetic resonance (MRI), computed tomography (CT), and echocardiography, in evaluation these patients. Methods. In total, 81 consecutive patients with CTD suspected PH underwent cardiac MRI, CT, right heart catheterization (RHC) within 48 hours. Functional MRI variables [ventricle areas...
Purpose To assess the diagnostic accuracy of magnetic resonance imaging (MRI) perfusion against single photon emission tomography (SPECT) screening for chronic thromboembolic pulmonary hypertension (CTEPH). Ventilation/perfusion (V/Q) scintigraphy is recommended to screen suspected CTEPH. It has previously been shown that 3D dynamic contrast‐enhanced (DCE) lung MRI a similar sensitivity diagnosing CTEPH in comparison planar scintigraphy; however, now largely replaced by SPECT, due higher...
Computed tomography (CT) pulmonary angiography is widely used in patients with suspected hypertension (PH). However, the diagnostic and prognostic significance remains unclear. The aim of this study was to (a) build a CT model (b) test its significance.Consecutive PH undergoing routine right heart catheterisation (RHC) were identified. Axial reconstructed images derive metrics. Multivariate regression analysis performed derivation cohort identify predict mPAP ≥ 25 mmHg (the existing ESC...
Background Cardiac MRI measurements have diagnostic and prognostic value in the evaluation of cardiopulmonary disease. Artificial intelligence approaches to automate cardiac segmentation are emerging but require clinical testing. Purpose To develop evaluate a deep learning tool for quantitative functional studies assess its use prognosis patients suspected having pulmonary hypertension. Materials Methods A retrospective multicenter multivendor data set was used learning–based contouring...
Microvascular abnormalities and impaired gas transfer have been observed in patients with COVID-19. The progression of pulmonary changes these remains unclear.
Dynamic contrast–enhanced (DCE) time‐resolved magnetic resonance (MR) imaging is a technique whereby the passage of an intravenous contrast bolus can be tracked through pulmonary vascular system. The aim this study was to investigate prognostic significance DCE‐MR blood transit times in patients with arterial hypertension (PAH). Seventy‐nine diagnosed PAH underwent DCE at 1.5 T using three‐dimensional spoiled gradient echo sequence. two parameters, full width half maximum (FWHM) first‐pass...
Purpose To derive and test multiparametric cardiac MRI models for the diagnosis of pulmonary hypertension (PH). Materials Methods Images patient data from consecutive patients suspected having PH who underwent right-sided heart catheterization (RHC) between 2012 2016 were retrospectively reviewed. Of 2437 MR images identified, 603 fit inclusion criteria. The mean age was 61 years (range, 18–88 years; women, 60 [range, 18–84 years]; men, 62 22–88 years]). In first 300 (derivation cohort),...
Abstract Aims Pulmonary arterial hypertension (PAH) is a rare but serious disease associated with high mortality if left untreated. This study aims to assess the prognostic cardiac magnetic resonance (CMR) features in PAH using machine learning. Methods and results Seven hundred twenty-three consecutive treatment-naive patients were identified from ASPIRE registry; 516 included training, 207 validation cohort. A multilinear principal component analysis (MPCA)-based learning approach was used...
Objectives To determine the prognostic value of patterns right ventricular adaptation in patients with pulmonary arterial hypertension (PAH), assessed using cardiac magnetic resonance (CMR) imaging at baseline and follow-up. Methods Patients attending Sheffield Pulmonary Vascular Disease Unit suspected were recruited into ASPIRE (Assessing Spectrum Identified a REferral Centre) Registry. With exclusion congenital heart disease, consecutive PAH followed up until date census or death. Right...
To evaluate the utility of 1.5-T noncontrast magnetic resonance (MR) imaging lung parenchyma and to compare it with computed tomography (CT) in assessment interstitial disease other morphologic abnormalities.Institutional review board approval was obtained for retrospective image analysis. A total 236 patients who underwent MR CT as part their suspected pulmonary hypertension were included this study. Lung performed a system stack axial two-dimensional balanced steady-state free precession...
Native T1 may be a sensitive, contrast-free, non-invasive cardiovascular magnetic resonance (CMR) marker of myocardial tissue changes in patients with pulmonary artery hypertension. However, the diagnostic and prognostic value native mapping this patient group has not been fully explored. The aim work was to determine whether elevation hypertension: (a) varies according hypertension subtype; (b) (c) is associated ventricular function interaction. Data were retrospectively collected from...
Accurately identifying patients with pulmonary hypertension (PH) using noninvasive methods is challenging, and right heart catheterization (RHC) the gold standard. Magnetic resonance imaging (MRI) has been proposed as an alternative to echocardiography RHC in assessment of cardiac function hemodynamics suspected PH. The aim this study was assess whether machine learning computational modeling techniques image-based metrics PH can improve diagnostic accuracy MRI Seventy-two attending a...
The volumetric flow rate (VFR) waveform over the cardiac cycle in cerebral vasculature is a significant factor many studies, which involve cerebrovascular function. Perhaps contrary to expectation, literature this area sparse and characteristics of blood waveforms are ill defined. A better understanding variation pulsatility may aid our knowledge risk factors involved diseases conditions, such as stroke, arteriovenous malformation, or aneurysm rupture. This study sought characterise at...