A5036485543- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Atomic and Subatomic Physics Research
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced MRI Techniques and Applications
- Cardiovascular Issues in Pregnancy
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Vascular Anomalies and Treatments
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Effects of Exercise
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Cardiovascular and Diving-Related Complications
- Connective Tissue Growth Factor Research
- Liver Disease and Transplantation
- Cardiovascular and exercise physiology
- Nuclear Physics and Applications
- Heart rate and cardiovascular health
University of Sheffield
2011-2024
Royal Hallamshire Hospital
2012-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2012-2024
Pulmonary Vascular Research Institute
2011-2020
National Health Service
2020
Northern General Hospital
2015-2016
Pulmonary hypertension (PH) is a heterogeneous condition. To date, no registry data exists reflecting the spectrum of disease across five diagnostic groups encountered in specialist referral centre. Data was retrieved for consecutive, treatment-naïve cases diagnosed between 2001 and 2010 using catheter-based approach. 1,344 patients were enrolled, with mean follow-up 2.9 yrs. The 3-yr survival 68% pulmonary arterial (PAH), 73% PH associated left heart disease, 44% lung (PH-lung), 71% chronic...
The phenotype and outcome of severe pulmonary hypertension in chronic obstructive disease (COPD) is described small numbers, predictors survival are unknown. Data was retrieved for 101 consecutive, treatment-naïve cases COPD. Mean ± SD follow-up 2.3 1.9 years. 59 patients with COPD hypertension, defined by catheter mean artery pressure ≥40 mmHg, had significantly lower carbon monoxide diffusion, less airflow obstruction but not different emphysema scores on computed tomography compared to 42...
Cardiovascular Magnetic Resonance (CMR) imaging is accurate and reproducible for the assessment of right ventricular (RV) morphology function. However, diagnostic accuracy CMR derived RV measurements detection pulmonary hypertension (PH) in patients with suspected PH clinic setting not well described. We retrospectively studied 233 consecutive treatment naïve including 39 no who underwent heart catheterisation (RHC) within 48hours. The multiple mPAP ≥ 25 mmHg was assessed using Fisher's...
Rationale: Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and Respiratory the REVEAL (North American Registry to Evaluate Early Long-Term PAH Disease Management) risk score calculator (REVEAL 2.0) identify thresholds predict 1-year mortality.Objectives: This study evaluates whether cardiac magnetic resonance imaging (MRI) can be identified used aid stratification facilitate decision-making.Methods: Consecutive patients with (n = 438)...
Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with disease decline surgery. There are currently no published data on this patient group. The aim study was to identify outcomes and prognostic factors in large cohort consecutive CTEPH.Data were collected consecutive, treatment-naive CTEPH at Vascular Disease Unit Royal Hallamshire Hospital (Sheffield, UK) between 2001 2014.Of...
We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) thrombus (10%) were exclusively seen PAH-congenital heart disease. Oesophageal dilation (46%) was most frequent PAH-systemic sclerosis. Ground glass opacification (GGO) (41%), pericardial effusion (38%), lymphadenopathy (19%) pleural (11%) common. On multivariate analysis, inferior vena...
Background Diagnostic rates and risk factors for the subsequent development of chronic thromboembolic pulmonary hypertension (CTEPH) following embolism (PE) are not well defined. Methods Over a 10-year period (2010–2020), consecutive patients attending PE follow-up clinic in Sheffield, UK (population 554 600) all diagnosed with CTEPH at (PH) referral centre Sheffield (referral population estimated 15–20 million) were included. Results Of 1956 3 months diagnosis acute PE, 41 cumulative...
The aim of this study was to evaluate the clinical use magnetic resonance imaging measurements related pulmonary artery stiffness in evaluation hypertension (PH).A total 134 patients with suspected PH underwent right heart catheterization (RHC) and on a 1.5-T scanner within 2 days. Phase contrast at trunk cine cardiac views were acquired. Pulmonary area change (AC), relative AC (RAC), compliance (AC/pulse pressure from RHC), distensibility (RAC/pulse ventricular functional indices, mass all...
There are limited data on the prognostic value of cardiovascular magnetic resonance measurements in idiopathic pulmonary arterial hypertension, with no studies investigating impact correction indices for age and sex value.Consecutive patients hypertension underwent imaging at 1.5T. Steady-state free precession cardiac volumes mass were corrected age, sex, body surface area according to reference significance assessed. A total 80 identified, 23 died during mean follow-up 32±14 months....
Objective. Pulmonary arterial hypertension (PAH) is a life-threatening complication of connective tissue diseases (CTD). Our aim was to compare the diagnostic utility noninvasive imaging modalities, i.e., magnetic resonance (MRI), computed tomography (CT), and echocardiography, in evaluation these patients. Methods. In total, 81 consecutive patients with CTD suspected PH underwent cardiac MRI, CT, right heart catheterization (RHC) within 48 hours. Functional MRI variables [ventricle areas...
There are limited published data defining survival and treatment response in patients with mild lung disease and/or reduced gas transfer who fulfil diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH). Patients diagnosed IPAH between 2001 2019 were identified the ASPIRE (Assessing Spectrum of Pulmonary Hypertension Identified at a Referral Centre) registry. Using prespecified based on computed tomography (CT) imaging spirometry, diagnosis no termed no-LD (n=303), those...
Dynamic contrast–enhanced (DCE) time‐resolved magnetic resonance (MR) imaging is a technique whereby the passage of an intravenous contrast bolus can be tracked through pulmonary vascular system. The aim this study was to investigate prognostic significance DCE‐MR blood transit times in patients with arterial hypertension (PAH). Seventy‐nine diagnosed PAH underwent DCE at 1.5 T using three‐dimensional spoiled gradient echo sequence. two parameters, full width half maximum (FWHM) first‐pass...
To evaluate the utility of 1.5-T noncontrast magnetic resonance (MR) imaging lung parenchyma and to compare it with computed tomography (CT) in assessment interstitial disease other morphologic abnormalities.Institutional review board approval was obtained for retrospective image analysis. A total 236 patients who underwent MR CT as part their suspected pulmonary hypertension were included this study. Lung performed a system stack axial two-dimensional balanced steady-state free precession...
Abstract Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that an inadequate response to dual therapy a phosphodiesterase type‐5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended either intensify oral adding selective prostacyclin (IP) agonist (selexipag), or switching from PDE5i soluble guanylate‐cyclase stimulator...
Echocardiography is widely used in the investigation of patients with suspected SSc-associated pulmonary arterial hypertension (SSc-PAH). We investigated whether CT angiography (CTPA) provides additive diagnostic value.Data for 89 consecutive SSc-PAH undergoing echocardiography, CTPA and right heart catheterization were reviewed. Pulmonary artery diameter (dPA) ascending aorta (dAA), left ventricular (dRV dLV) grade tricuspid regurgitation (TR(CT)) measured at gradient (TG(ECHO))...
Rationale: Exercise capacity predicts mortality in pulmonary arterial hypertension (PAH), but limited data exist on the routine use of maximal exercise testing.Objectives: This study evaluates a simple-to-perform test (the incremental shuttle walking test) and its risk stratification PAH.Methods: Consecutive patients with were identified from ASPIRE (Assessing Spectrum Pulmonary Identified at REferral centre) registry (2001-2018). Thresholds for levels baseline tested follow-up, their...
This is a repository copy of Magnetic resonance imaging ventilation and perfusion changes in response to pulmonary endarterectomy chronic thromboembolic hypertension.