A5031757119- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Myasthenia Gravis and Thymoma
- Atrial Fibrillation Management and Outcomes
- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Parkinson's Disease and Spinal Disorders
- Healthcare Policy and Management
- Neurological Disease Mechanisms and Treatments
- COVID-19 epidemiological studies
- Healthcare cost, quality, practices
- Dementia and Cognitive Impairment Research
- Tuberculosis Research and Epidemiology
- Cardiac Arrhythmias and Treatments
- Ethics in Clinical Research
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Primary Care and Health Outcomes
- Venous Thromboembolism Diagnosis and Management
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- COVID-19 Impact on Reproduction
EVRAZ (United Kingdom)
2018-2024
UCB Pharma (United Kingdom)
2024
London School of Hygiene & Tropical Medicine
2023-2024
National Institute for Health Research
2023-2024
Newcastle University
2017-2024
UK Health Security Agency
2023
Akershus University Hospital
2021
Ithaka Harbors
2021
Diagnostics for the Real World (United Kingdom)
2017-2020
Newcastle Hospitals - Campus for Ageing and Vitality
2017
Cerebral white matter lesions (WML) encompass axonal loss and demyelination, the pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However, WML may also result from activation of Wallerian degeneration as a consequence cortical Alzheimer’s (AD) pathology, i.e. hyperphosphorylated tau (HPτ) amyloid-beta (Aβ) deposition. seen in AD have posterior predominance compared non-demented individuals but it unclear whether pathological molecular signatures differ between these...
Immunocompromised individuals are not optimally protected by COVID-19 vaccines and potentially require additional preventive interventions to mitigate the risk of severe COVID-19. We aimed characterise describe across immunocompromised groups as pandemic began transition an endemic phase.
Abstract Cerebral white matter lesions (WML) encompass axonal loss and demyelination are assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our previous study in the parietal lobe revealed that WML Alzheimer’s (AD) linked degenerative secondary deposition of cortical AD pathology. Furthermore, neuroimaging data suggest pathomechanisms for development differ between anterior posterior lobes AD-associated mechanism driving disruption, both vascular mechanisms...
Patients with generalized myasthenia gravis (MG) often experience debilitating exacerbations, the possibility of life-threatening respiratory crises requiring hospitalization. Long-term longitudinal studies are needed to understand burden MG, including in patients whose disease is refractory conventional treatment.A retrospective, longitudinal, cohort study was conducted England aged ≥ 18 years treatment-refractory or non-refractory using data recorded during 1997-2016 Clinical Practice...
The blood-brain barrier (BBB) regulates cerebrovascular permeability and leakage of blood-derived fibrinogen. Dysfunction the BBB has been associated with cerebral arteriolosclerosis small vessel disease (SVD) white matter lesions (WML). Furthermore, dysfunction is pathogenesis Alzheimer's (AD) presence CSF plasma proteins suggested to be a potential biomarker AD. We aimed determine if extravascular fibrinogen in was development AD hallmark pathologies, i.e., hyperphosphorylated tau (HPτ)...
Abstract National test-negative-case-control (TNCC) studies are used to monitor COVID-19 vaccine effectiveness in the UK. A questionnaire was sent participants from first published TNCC study conducted by UK Health Security Agency, assess for potential biases and changes behaviour related vaccination. The original included symptomatic adults aged ≥70 years testing between 08/12/2020 21/02/2021. cases controls tested 1–21 February 2021. In this study, 8648 individuals responded (36.5%...
Aims: To examine healthcare resource utilization associated with refractory myasthenia gravis (MG) in England.Materials and methods: This was a retrospective cohort study of linked data from the Clinical Practice Research Datalink Hospital Episode Statistics database collected between 1997 2016. Included patients were ≥18 years age at index MG diagnosis. Patients identified using an algorithm based on treatments received. Healthcare since date compared non-refractory cohorts.Results: The...
Dementia is a common comorbidity in patients with atrial fibrillation (AF) and treatment guidelines recommend oral anticoagulant (OAC) therapy for AF dementia unless concordance cannot be ensured by the caregiver. Despite this, literature reports low prescribing of OAC these patients. This study investigated possible factors associated non-prescribing newly diagnosed non-valvular (NVAF) at age ≥ 65 years between 2013 2017 using Clinical Practice Research Datalink Hospital Episodes Statistics...
Abstract Objective To assess the feasibility and effect of using proxy markers health-seeking behaviour healthcare access to quantify adjust for confounding in observational studies influenza COVID-19 vaccine effectiveness (VE). Design Cohort study VE 2019/2020 season early (December 2020 – March 2021). Setting Primary care data pre-linked secondary death England. Participants Individuals aged ≥66 years on 1 September 2019. Interventions Vaccination with any vaccination or either a BNT162b2...
Abstract Biallelic null or hypomorphic variants in JAK3 cause SCID and less frequently Omenn syndrome. We investigated homozygous mutations two patients, expression function of a novel R431P variant Immunophenotyping PBMC from the patient with was undertaken, by flow cytometry Phosflow after stimulation IL-2, IL-7, IL-15. Western blotting. report patients clinical features One had previously described R775H variant, second variant. normal immortalised EBV-LCL cells but reduced...
Abstract Background Spinal muscular atrophy (SMA) is a rare, progressive, neuromuscular disorder. Recent advances in treatment require an updated assessment of burden to inform reimbursement decisions. Objectives To quantify healthcare resource utilisation (HCRU) and cost care for patients with SMA. Methods Cohort study SMA identified the Swedish National Patient Registry (2007–2018), matched reference cohort grouped into four types (1, 2, 3, unspecified adult onset [UAO]). HCRU included...
Objective To assess the feasibility of identifying markers health-seeking behaviour and healthcare access in UK electronic health records (EHR), for populations at risk poor outcomes adjusting confounding epidemiological studies. Design Cross-sectional observational study using Clinical Practice Research Datalink Aurum prelinked to Hospital Episode Statistics. Setting Individual-level routine clinical data from 13 million patients across general practices (GPs) secondary England....
Data other than that from clinical trials are important for healthcare decision making. However, unlike the vocal calls seen more open access to trial data, there limited efforts being made ensure agencies collect real-world data (RWD) share this, despite its importance. There many RWD sources across world could be readily exploited research once shared. policy and privacy questions need tackled, but opening up sharing offers remarkable potential improvements in care individuals effective...
Abstract Objective To assess the feasibility of identifying markers health-seeking behaviour and healthcare access in UK electronic health records (EHR), for populations at risk poor outcomes, adjusting confounding epidemiological studies. Design Cross sectional observational study using Clinical Practice Research Datalink (CPRD) Aurum pre-linked to Hospital Episode Statistics. Setting Individual-level routine clinical data from 13 million patients across general practices (GPs) secondary...
Huntington's disease (HD) is a rare, neurodegenerative and its complex motor, cognitive psychiatric symptoms exert lifelong clinical burden on both patients their families.To describe the natural history of HD.This longitudinal cohort study used data from linked Swedish national registries to occurrence comorbidities (acute chronic), symptomatic treatments mortality in an incident individuals who either received first diagnosis HD above (adult onset HD; AoHD) or below (juvenile-onset JoHD)...
Cerebral white matter lesions (WML), as seen histologically, or hyperintensities (WMH) on MRI, are a frequent finding in both demented and non-demented elderly. WML encompass demyelination axonal loss, the pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However, posterior region, may also occur result of degenerative loss secondary cortical Alzheimer's (AD) pathology, i.e., hyperphosphorylated tau (HPτ) amyloid-beta (Aβ) Wallerian degeneration. It not clear whether...
Abstract Background Maternal characteristics like medical history and health-related risk factors can influence the incidence of pregnancy outcomes pregnancy-related events interest (EIs). Data on these endpoints in low-risk pregnant women are needed for appropriate external safety comparisons maternal immunization trials. To address this need, study estimated proportions EIs different cohorts (including pregnancies) England, contained Clinical Practice Research Datalink (CPRD) Pregnancy...
Recent reports have suggested that internet search behaviour may be a valuable tool to estimate melanoma incidence and mortality. Previous studies used incorrect statistical methods, were focussed on the United States and/or did not use non-cancer control terms provide context for interpreting effects seen with cancer-related terms. Using more robust methods we found no cancer significantly, or strongly correlated in 6 countries.
Journal Article Paresthesia in a Rhesus Monkey Associated with Thalamic Lesion, and its Alleviation by Postcentral Cortical Excision Get access J. R. Whittier, Whittier Departments of Nerology College Physicians Surgeons, Columbia University Bacteriology, New York State Psychiatric Institute, York, N. Y. Search for other works this author on: Oxford Academic PubMed Google Scholar S. E. Graham, Graham Kopeloff Neuropathology & Experimental Neurology, Volume 8, Issue 1, January 1949, Pages...