Chronic obstructive pulmonary disease (COPD) may increase the risk and severity of pertussis infection. Health care resource utilization (HCRU) direct medical costs (DMC) treating among patients with COPD are unknown. Reported incidence individuals aged ≥ 50 years was assessed in Clinical Practice Research Datalink Hospital Episode Statistics databases during 2009–2018 using a retrospective cohort design. HCRU DMC from National Service perspective were compared between propensity...

Objectives: In 2013, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) updated management strategy on COPD based severity using a combined assessment of symptoms, degree airflow limitation, and number exacerbations. This study quantified prevalence incidence in United Kingdom estimated disease by GOLD 2013 categories A/B (low risk) C/D (high risk). Methods: The Clinical Practice Research Datalink was used to identify patients ≥40 years. Patient characteristics were described,...

Real-world data is that collected outside the constraints of controlled clinical trials and increasingly informing decision-making in healthcare. The landscape real-world United Kingdom set to evolve over coming months as government plans build on databases currently place by collecting patient from all family practices linking this information with hospital records. This initiative, called care.data, has potential be an invaluable resource. However, programme been criticized grounds...

Background. Natural killer (NK) and natural T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods. C57BL/6 mice were infected intratracheally with 5 × 10(5) cfu of Streptococcus pneumoniae. Animals divided into sham group (Sham); pretreated isotype control antibody (CON) group; anti-asialo GM1 (NKd) anti-CD1d monoclonal (NKTd) before challenge. Serum tissue samples analyzed for load, cytokine levels, splenocyte apoptosis rates,...

Objective The aim of the study was to estimate burden and direct medical costs unintended pregnancy public payer in Spain.

Background Until recently, treatment options were limited for patients with acute myeloid leukemia and myelodysplastic syndrome (AML MDS) who are ineligible intensive chemotherapy. Owing to the condition’s rapid progression, it is difficult identify what most important when making decisions. Patients’ needs can be better addressed by gaining a deeper understanding of their perspectives, which valuable in decision-making process. The Food Drug Administration recently encouraged use social...

The impact of pertussis in individuals with asthma is not fully understood. We estimated the incidence, health care resource utilization (HCRU), and direct medical costs (DMC) patients asthma.In this retrospective cohort study, incidence rate (identified using diagnostic codes) among aged ≥50 years an diagnosis was assessed during 2009-2018 Clinical Practice Research Datalink Hospital Episode Statistics databases. HCRU DMC were compared - between diagnoses (asthma+/pertussis+) propensity...

Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, affects people of all ages. Older adults are particularly susceptible to its severe outcomes and complications.In this retrospective cohort study, the incidence rate pertussis among individuals aged ≥ 50 years was assessed during 2009-2018 using Clinical Practice Research Datalink Hospital Episode Statistics databases, United Kingdom. Health care resource utilisation (HCRU) direct medical costs (DMCs) were...

Objective:Publications containing recent, real-world data on the economic impact of hip fractures in UK are lacking. This retrospective electronic medical records database analysis assessed medication and healthcare resource use, direct costs, factors predicting increased use costs adult fracture patients.Methods:Data were obtained from Clinical Practice Research Datalink linked to Hospital Episode Statistics for patients hospitalized their first between January 1, 2006 March 31, 2011 (index...

Preterm labour and birth (PTL/PTB) is characterised by major health developmental risks for children, life-changing consequences their families, substantial healthcare economic challenges wider society. While it known that PTL/PTB impacts infant costs in the short long term Germany, maternal have not been described detail. The aim of this study was to comprehensively describe resource use among mothers during pregnancy, at hospitalisation delivery, up three years after delivery-overall...

<ns4:p><ns4:bold>Background</ns4:bold>: The objective of this study was to investigate the design characteristics Post-Authorisation Studies (PAS) requested by European Medicines Agency which were recorded on Union (EU) PAS Register held Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP).</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: We undertook a cross-sectional descriptive analysis all studies registered EU as 18<ns4:sup>th </ns4:sup>October 2016.</ns4:p><ns4:p>...

The objective of this study was to investigate the design characteristics Post-Authorisation Studies (PAS) requested by European Medicines Agency which were recorded on Union (EU) PAS Register held Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP).We undertook a cross-sectional descriptive analysis all studies registered EU as 18 th October 2016.We identified total 314 Register, including 81 (26%) finalised, 160 (51%) ongoing 73 (23%) planned. Of those identified, 205...

Aims: This population-based, retrospective study quantified the rates of all-cause and pneumococcal pneumonia, meningitis septicemia in Norway from 2008 to 2009 determined proportions cases caused by vaccine serotypes. Methods: Data on patients with were obtained Norwegian Patient Registry, which collects hospitalization data all public hospitals based International Classification Diseases codes. Registry case records linked Surveillance System for Communicable provided serotype invasive...

Huntington's disease (HD) is a rare, neurodegenerative and its complex motor, cognitive psychiatric symptoms exert lifelong clinical burden on both patients their families.To describe the natural history of HD.This longitudinal cohort study used data from linked Swedish national registries to occurrence comorbidities (acute chronic), symptomatic treatments mortality in an incident individuals who either received first diagnosis HD above (adult onset HD; AoHD) or below (juvenile-onset JoHD)...

There is limited information about the initiation of triple therapy (TT) in patients with chronic obstructive pulmonary disease (COPD) primary care. This was an observational, population-based study identified from a care electronic medical records database Catalonia 2011 to 2015 aimed identify use TT newly diagnosed COPD. A total 69,668 were whom 11,524 (16.5%) initiated TT, 8626 at or immediately after COPD diagnosis. Among them, 72.3% GOLD A/B, 14.6% frequent exacerbators, and 7.1% had...

Abstract Background Maternal characteristics like medical history and health-related risk factors can influence the incidence of pregnancy outcomes pregnancy-related events interest (EIs). Data on these endpoints in low-risk pregnant women are needed for appropriate external safety comparisons maternal immunization trials. To address this need, study estimated proportions EIs different cohorts (including pregnancies) England, contained Clinical Practice Research Datalink (CPRD) Pregnancy...

Abstract Purpose Quantitative benefit‐risk (B‐R) assessments are used to characterize treatment by combining key benefits and risks into a single metric but have historically been done for the “average” patient. Our aim was conduct an individualized assessment oral antiplatelet vorapaxar trial real‐world data further personalize profiles. Methods Using linked UK health care databases, we developed risk prediction equations ischemic bleeding events using Cox proportional hazards models. Trial...

Background and purpose To investigate resource use burden associated with spina bifida ( SB ) in Germany. Methods A questionnaire was used to obtain information on ‐related healthcare assistive technologies for the last 1 10 years. Individuals were recruited at a tertiary specialist clinic. participate, persons required cognitive ability respond or caregiver answer questions their behalf. They could personal medical charts other records answer. The analyses included assessment of frequency...

Background: Little is known about the association between respiratory events prior to diagnosis of chronic obstructive pulmonary disease (COPD) and future clinical outcomes in Japan. We investigated pre-COPD incidence exacerbations a cohort newly diagnosed COPD patients Patients Methods: Data were retrieved from JMDC claims database. ≥ 40 years old with first (≥ 1 hospitalization or 2 outpatient for COPD) 2010 2016 included. The rate (IR) without any event (including lower tract infection...

There are limited data describing adverse infant outcomes in infants born to women with a low risk of complications during pregnancy, such as those who may be enrolled maternal immunization trials. This retrospective study estimated incidence proportions different cohorts liveborn England between 2005 and 2017.The 10 were calculated for from pregnancies represented the Clinical Practice Research Datalink (CPRD) Mother-Baby Link (MBL) linkage Hospital Episode Statistics (HES). Three designed:...