A5091022953- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Statistical Methods in Clinical Trials
- Respiratory and Cough-Related Research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Statistical Distribution Estimation and Applications
- Healthcare Systems and Practices
- Respiratory Support and Mechanisms
- Hepatitis B Virus Studies
- Advanced Statistical Methods and Models
- Acne and Rosacea Treatments and Effects
- Chronic Disease Management Strategies
- vaccines and immunoinformatics approaches
- Statistical Methods and Bayesian Inference
- Gastrointestinal disorders and treatments
- Otolaryngology and Infectious Diseases
- Neonatal Respiratory Health Research
GlaxoSmithKline (Belgium)
2016-2025
GlaxoSmithKline (United States)
2009-2025
GlaxoSmithKline (India)
2015-2019
GlaxoSmithKline (United Kingdom)
2012-2014
GlaxoSmithKline (Switzerland)
2012
The University of Western Australia
2010
Murdoch Children's Research Institute
2010
The University of Melbourne
2010
Tilburg University
2000-2002
<h3>Background</h3> The aetiology of acute exacerbations COPD (AECOPD) is incompletely understood. Understanding the relationship between chronic bacterial airway infection and viral exposure may explain incidence seasonality these events. <h3>Methods</h3> In this prospective, observational cohort study (NCT01360398), patients with aged 40–85 years underwent sputum sampling monthly at exacerbation for detection bacteria viruses. Results are presented subjects in full cohort, followed 1 year....
Case reports have described herpes zoster (HZ) in patients with coronavirus disease 2019 (COVID-19). However, this constitutes low-quality evidence for an association. We therefore performed a retrospective cohort study to assess the risk of developing HZ following COVID-19 diagnosis.We compared incidence ≥50-year-olds diagnosed vs those never COVID-19. used data from US MarketScan Commercial Claims and Encounters Medicare Supplemental (3/2020-2/2021) Optum Clinformatics Data Mart...
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts response to treatment, especially corticosteroids. We studied the nature of eosinophilic COPD prospectively examine stability this phenotype and its dynamics across exacerbations, associations with clinical phenotype, exacerbations infection.127 patients aged 40-85 years moderate very severe underwent repeated blood sputum sampling at stable visits within 72 h exacerbation for 1 year.Blood eosinophils ≥2% was...
Abstract Background The number of patients with skin and soft tissue infections (SSTIs) in the United States appeared to be increasing well into 21st century. However, no recent data have confirmed this trend. Methods This retrospective, observational cohort study used claims over 11 years (2010–2020) from Optum's de-identified Clinformatics Data Mart Database. SSTI episodes, complications, comorbidities were identified using International Classification Diseases codes. Annual incidence...
Despite longstanding recommendations for routine vaccination against influenza; pneumococcal; tetanus, diphtheria, acellular pertussis (Tdap); and herpes zoster (HZ) among the United States general adult population, vaccine uptake remains low. Understanding factors that influence coverage variability beyond national level are important steps toward developing targeted strategies increasing coverage. A retrospective analysis was conducted using data from Behavioral Risk Factor Surveillance...
Abstract Background The adjuvanted recombinant zoster vaccine (RZV) was approved by the US Food and Drug Administration (FDA) for HZ prevention in adults ≥50 YOA 2017 ≥18 who are at increased risk of due to immunodeficiency or immunosuppression 2021 (FDA, 2023. Shingrix. STN: 125614). Autoimmune disease (AID) patients developing compared general population. This real-world evidence (RWE) study assessed RZV effectiveness (VE) with selected AIDs (rheumatoid arthritis, inflammatory bowel...
Chronic obstructive pulmonary disease (COPD) may increase the risk and severity of pertussis infection. Health care resource utilization (HCRU) direct medical costs (DMC) treating among patients with COPD are unknown. Reported incidence individuals aged ≥ 50 years was assessed in Clinical Practice Research Datalink Hospital Episode Statistics databases during 2009–2018 using a retrospective cohort design. HCRU DMC from National Service perspective were compared between propensity...
COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects pathology and poorly related to clinical outcome, so other tools are required investigate the disease. We sought explore relationships between quantitative CT analysis with functional, inflammatory infective assessments identify utility imaging stratify better predict outcomes response. Patients from AERIS study moderate-very severe...
COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies pneumonia in focused on hospitalised and are not representative the ambulant population. Therefore, we sought to determine incidence aetiology acute exacerbation events evidence pneumonic radiographic infiltrates an outpatient cohort. One hundred twenty-seven moderate very severe aged 42–85...
Non-typeable Haemophilus influenzae (NTHi) is a major cause of various respiratory diseases. The development an effective vaccine against NTHi mandates new approaches beyond conjugated vaccines as this opportunistic bacterium non-encapsulated. Here we report on the safety, reactogenicity and immunogenicity multi-component investigational based three conserved surface proteins from (proteins D [PD], E [PE] Pilin A [PilA]) in two observer-blind phase I studies.In first study (NCT01657526), 48...
Invasive meningococcal disease (IMD) is an uncommon known for its acute phase mortality and long-term sequelae. The objective was to assess the impact of IMD on post-discharge risk dependence French state financial aid. A 6-year retrospective analysis in national insurance database (SNIIRAM) assessed cases (both during post-discharge) matched controls as well benefit claims (i.e., salary loss compensation [SLC], sickness [ALD] complementary health [CMUc]). Observed survival data were...
Early provisions of the Affordable Care Act (ACA) reduced financial barriers to preventive care, including routinely recommended vaccines; however, vaccination coverage remains suboptimal. This study examined characteristics routine adult vaccinations and potential missed opportunities for through lens healthcare resource utilization among adults in ACA era.This was a retrospective analysis claims from Truven Health MarketScan Commercial Claims Encounters (CCAE), Medicare Supplemental (MS),...
Invasive meningococcal disease (IMD) is an uncommon but serious infectious disease. Its economic burden known to be high poorly characterised. The objective of this study was determine costs, as captured in the healthcare claims database, incurred by all patients hospitalised for IMD France over a 6-year period.This case-control performed using French national public health insurance database (SNDS). Cases comprised individuals with acute between 2012 and 2017 inclusive. For each case, three...
Abstract Background In adults aged 50 + years, vaccine-preventable diseases (VPDs) pose a significant health burden and can lead to additional ‘downstream effects’ of infection beyond the acute phase e.g., increasing risk for non-communicable disease exacerbating chronic conditions. The aim was understand quantify VPD downstream effects in hospitalised United States. Methods This retrospective observational study analysed hospitalisation claims data (2016–2019) with 1-year follow-up,...
Meningococcal disease incidence is highest in children younger than 2 years of age, yet there no US-licensed vaccine for this age group. A phase III study evaluated the immunogenicity and safety an investigational Haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroups C Y-tetanus toxoid conjugate (HibMenCY).A total 4180 infants were randomly assigned to receive HibMenCY at ages 2, 4, 6, 12 15 months or licensed Hib tetanus (ActHIB) 6 conjugated N outer membrane protein...
The association between exacerbation aetiology and frequency is poorly understood. We analysed 2-year follow-up data from a prospective observational study of patients with chronic obstructive pulmonary disease (COPD) ( www.clinicaltrials.gov identifier number NCT01360398 ) to evaluate year-to-year variation in related aetiology. A total 127 underwent blood sputum sampling monthly at detect respiratory infections eosinophilic inflammation; 103 continued into year 2 88 completed both years....
The impact of pertussis in individuals with asthma is not fully understood. We estimated the incidence, health care resource utilization (HCRU), and direct medical costs (DMC) patients asthma.In this retrospective cohort study, incidence rate (identified using diagnostic codes) among aged ≥50 years an diagnosis was assessed during 2009-2018 Clinical Practice Research Datalink Hospital Episode Statistics databases. HCRU DMC were compared - between diagnoses (asthma+/pertussis+) propensity...
Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, affects people of all ages. Older adults are particularly susceptible to its severe outcomes and complications.In this retrospective cohort study, the incidence rate pertussis among individuals aged ≥ 50 years was assessed during 2009-2018 using Clinical Practice Research Datalink Hospital Episode Statistics databases, United Kingdom. Health care resource utilisation (HCRU) direct medical costs (DMCs) were...
Study assessed the immunogenicity and safety of an investigational Haemophilus influenzae type b-Neisseria meningitidis serogroups C Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) in infants.In a single-blinded, controlled study, 609 infants were randomized 1:1 to receive primary vaccination (2, 4, 6 months) with either HibMenCY-TT or monovalent b tetanus (Hib-TT), co-administered combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus 7-valent pneumococcal...
Background: Neisseria meningitidis serogroups B, C, and Y cause most meningococcal disease in industrialized countries. A Haemophilus influenzae type b-meningococcal C Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) was evaluated. Methods: total of 1104 infants (randomized 3:1:1) were vaccinated at 2, 4, 6 months with HibMenCY-TT, MenC-CRM197 + Hib-TT, or Hib-TT. At 12 to 15 months, HibMenCY-TT MenC-CRM-primed children received HibMenCY-TT; Hib-TT-primed N. serogroup B Hib-outer membrane...
The aetiology of acute exacerbations chronic obstructive pulmonary disease (COPD) remains incompletely understood and strategies for treatment prevention have not altered significantly many years. Improved understanding the role respiratory pathogens in COPD (AECOPD) is required use molecular microbiological techniques may lead to insights into host-pathogen interactions development more targeted therapeutic approaches.Acute Exacerbation Respiratory InfectionS (AERIS) a longitudinal...
A total of 236 infants received a fourth Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY) dose at 12 to 15 months. One month later, the proportion with anti–PRP antibody ≥1.0 μg/mL bactericidal titers ≥1:8 MenC MenY was 98.9%, 96.9%, 95.4%, respectively. year anti-PRP concentrations ≥0.15 μg/mL, persisted in 100%, 96.6%, 83.8%, The safety profile HibMenCY comparable Hib.
Abstract H. haemolyticus is often misidentified as NTHi due to their close phylogenetic relationship. Differentiating between the two important for correct identification and appropriate treatment of infective organism ensure any role in disease not being overlooked. Speciation however completely reliable by culture PCR methods loss haemolysis heterogeneity NTHi. Haemophilus isolates from COPD part AERIS study (ClinicalTrials - NCT01360398) were speciated analysing sequence data presence...
An investigational combined Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroups C Y tetanus toxoid conjugate vaccine (HibMenCY-TT) has been developed to protect infants from invasive disease caused by Hib these meningococcal without adding injections the immunization schedule. Incorporation of this novel into US vaccination schedule will require demonstration a lack immunologic interference with other routine pediatric vaccines. This study assessed immune response...