A5083447567- Vaccine Coverage and Hesitancy
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Respiratory viral infections research
- Global Cancer Incidence and Screening
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Genital Health and Disease
- Viral Infections and Immunology Research
- Hepatitis C virus research
- COVID-19 epidemiological studies
- Bacterial Infections and Vaccines
- Congenital Diaphragmatic Hernia Studies
- Pharmacovigilance and Adverse Drug Reactions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Biosimilars and Bioanalytical Methods
- Congenital Anomalies and Fetal Surgery
- Enterobacteriaceae and Cronobacter Research
- Respiratory and Cough-Related Research
- Hepatitis Viruses Studies and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Virology and Viral Diseases
European Medicines Agency
2021-2024
GlaxoSmithKline (Belgium)
2014-2024
Danish Medicines Agency
2023
Consumers, Health, Agriculture and Food Executive Agency
2020
GlaxoSmithKline (India)
2019
Weatherford College
2018
University of Regina
2018
Kimberly-Clark (Canada)
2018
GlaxoSmithKline (United States)
2014
Sanofi (France)
2008-2013
The aim of the present study was to assess which factors contribute lower prevalence allergic diseases in farmers’ children, and importance timing exposure. In a cross-sectional questionnaire survey, asthma symptoms, hay fever eczema were assessed, as well current, early prenatal farm-related exposures 1,333 children 566 reference aged 5–17 yrs. Farmers’ had incidence symptoms eczema. Current maternal exposure during pregnancy animals and/or grain reduced risk exposure–response association...
The "hygiene hypothesis" postulates that infections during infancy may protect against asthma and atopy. There is also some evidence antibiotic and/or paracetamol use increase the risk of asthma.The study measured association between infections, medication early in life at age 6-7 years. It involved 1584 children who had been notified to public health services with serious 0-4 years, 2539 sampled from general population. For both groups, postal questionnaires were completed by parents.There...
Data on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives this study were to measure and compare impact health-related quality life (HRQoL) HPV-related lower genital tract warts (GW) using several generic disease-specific instruments. Overall, 842 individuals with normal cytology (n = 241), borderline nuclear abnormalities and/or mild dyskaryosis 23), intraepithelial neoplasia (CIN)1 84), CIN2/3 203), vulval (VIN)2/3...
Abstract Objective To investigate the comparative vaccine effectiveness of heterologous booster schedules (ie, three doses) compared with primary (two and homologous mRNA (three during a period omicron predominance. Design Population based cohort analyses. Setting Denmark, Finland, Norway, Sweden, 27 December 2020 to 31 2022. Participants All adults aged ≥18 years who had received at least vaccination schedule AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain...
Abstract The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive. Here, we conducted population-based study including 357,806 vaccinated participants high-resolution HLA genotyping data, and subset 175,000 serology test results. We...
Background: Genital warts (GW) are common and increasing in young people. Ninety percent of GW due to Human Papillomavirus (HPV) types 6 11. The objective this study was assess the epidemiology management costs associated with Spain. Methods: A 1-year (2005) retrospective observational performed among a sample gynaecologists, dermatologists urologists six autonomous regions Men women newly diagnosed, recurrent or resistant were included. We estimated incidence (new cases) prevalence (also...
Few studies have examined how the absolute risk of thromboembolism with COVID-19 has evolved over time across different countries. Researchers from European Medicines Agency, Health Canada, and United States (US) Food Drug Administration established a collaboration to evaluate arterial (ATE) venous (VTE) in 90 days after diagnosis ambulatory (eg, outpatient, emergency department, nursing facility) setting seven countries North America (Canada, US) Europe (England, Germany, Italy,...
SUMMARY This study assessed risk factors for respiratory syncytial virus (RSV) hospitalization and disease severity in Wellington, New Zealand. During the southern hemisphere winter months of 2003–2005, 230 infants aged <24 hospitalized with bronchiolitis were recruited. RSV was identified 141 (61%) infants. Comparison data from all live hospital births same region (2003–2005) revealed three independent hospitalization: birth between February July [adjusted ratio (aRR) 1·62, 95%...
Abstract Purpose: The objective of the study was to examine association three exon 5 variants in O6-alkylguanine DNA alkyltransferase (AGT) gene involved repair mutagenic lesion formed by nitrosamines, with lung cancer risk never-smokers. Experimental Design: Exon AGT sequenced genomic from 136 cases and 133 hospital- or population-based controls for whom questionnaire information on second-hand smoke diet available determine frequencies Gly160Arg, Ile143Val, Lys178Arg variant alleles....
We estimated the number of women undergoing cervical cancer screening annually in Italy, rates abnormalities detected, and costs management abnormalities. The annual screened was from National Health Interview data. Data Italian Group for Cervical Cancer Screening were used to estimate positive, negative unsatisfactory Pap smears. incidence CIN (cervical intra-epithelial neoplasia) Emilia Romagna Registry. Patterns follow-up treatment using a typical disease approach based on national...
Abstract Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract infections in infants and children worldwide. In New Zealand, with RSV disease are hospitalized at a higher rate than other industrialized countries, without proportionate increase known risk factors. The molecular epidemiology Zealand has never been described. Therefore, we analyzed attachment glycoprotein (G) gene sequences from 106 subgroup A isolates collected between 1967 2003, 38 B...
Annual seasonal influenza vaccination is recommended for transplant recipients. No formal pharmacoepidemiology study has been published on the association between solid organ (SOT) rejection and with trivalent inactivated vaccines (TIIVs).The risk of SOT (liver, kidney, lung, heart or pancreas) after TIIV was assessed using a self-controlled case-series method (NCT01715792). recipients in England were selected from Clinical Practice Research Datalink linked Hospital Episode Statistics...
Objective To assess the risk of solid organ transplant (SOT) rejection after vaccination with adjuvanted (AS03) A/H1N1 2009 pandemic influenza vaccine Pandemrix . Design Self-controlled case series (SCCS) in UK Clinical Practice Research Datalink (CPRD) and its linked component Hospital Episodes Statistics (HES) inpatient database. Analyses were conducted using SCCS method for censored, perturbed or curtailed post-event exposure. Participants Of 184 recipients having experienced at least one...
Clinical trials have shown that AS03-adjuvanted H5N1 and A(H1N1)pdm09 vaccines are highly immunogenic, although with an increased reactogenicity profile relative to non-adjuvanted in terms of the incidence common injection site systemic adverse events (AEs). We evaluated pooled safety data from 22,521 adults who had received or influenza control vaccine purpose identify medically-attended AEs (MAEs), including subsets serious (SAEs), potentially immune-mediated diseases (pIMDs), special...
Cervical cancer is the second most common in European women aged 15-44 years. The aim of this study was to estimate direct cost managing invasive cervical Italy.Data from Italian Network Cancer Registries were used annual number new cases. To assess management costs, a typical pathway for each FIGO (Fédération Internationale de Gynécologie et d'Obstétrique) stage derived published guidelines. Data Modena Registry proportion patients by stage. This algorithm combined with tariffs outpatient...
Oncogenic human papillomaviruses (HPVs) are essential causes of cervical cancer. Screening prevents cancer by detecting precancerous lesions (cervical intraepithelial neoplasia, CIN). Our aim was to assess the annual number Pap smears and CIN diagnoses in Spain estimate associated management costs.A 1-year retrospective cross-sectional study conducted among 65 gynecologists from public primary health care centers 6 autonomous regions Spain. We documented total performed women with CIN. Data...
The aetiology of acute exacerbations chronic obstructive pulmonary disease (COPD) remains incompletely understood and strategies for treatment prevention have not altered significantly many years. Improved understanding the role respiratory pathogens in COPD (AECOPD) is required use molecular microbiological techniques may lead to insights into host-pathogen interactions development more targeted therapeutic approaches.Acute Exacerbation Respiratory InfectionS (AERIS) a longitudinal...