A5103216086- Maternal Mental Health During Pregnancy and Postpartum
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Prenatal Substance Exposure Effects
- Pregnancy and Medication Impact
- Diabetes Treatment and Management
- Child and Adolescent Psychosocial and Emotional Development
- Respiratory and Cough-Related Research
- Diabetes Management and Research
- Chronic Disease Management Strategies
- Spinal Dysraphism and Malformations
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Metabolism, Diabetes, and Cancer
- Schizophrenia research and treatment
- Dermatology and Skin Diseases
- Healthcare Policy and Management
- Advanced Causal Inference Techniques
- Reproductive Health and Contraception
- Vascular Malformations and Hemangiomas
- Global Cancer Incidence and Screening
- IL-33, ST2, and ILC Pathways
Manitoba Health
2014-2024
University of Manitoba
2014-2024
Canadians Living with HIV
2024
McGill University
2019-2023
University of British Columbia
2021-2023
George & Fay Yee Centre for Healthcare Innovation
2023
Jewish General Hospital
2021
University of Waterloo
2021
Saskatchewan Health Quality Council
2021
University of Toronto
2021
There is concern that antidiabetic incretin-based drugs, including dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, can increase the risk of heart failure. Ongoing clinical trials may not have large enough samples to effectively address this issue. We applied a common protocol in analysis multiple cohorts patients with diabetes. used health care data from four Canadian provinces, United States, Kingdom. With use nested case-control analysis, we matched...
To determine whether the use of incretin based drugs compared with sulfonylureas is associated an increased risk incident pancreatic cancer in people type 2 diabetes.Population cohort.Large, international, multicentre study combining health records from six participating sites Canada, United States, and Kingdom.A cohort 972,384 patients initiating antidiabetic between 1 January 2007 30 June 2013, follow-up until 2014.Within each we conducted nested case-control analyses, where cases were...
The association between incretin-based drugs, such as dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) agonists, acute pancreatitis is controversial.To determine whether the use of compared with 2 or more other oral antidiabetic associated an increased risk pancreatitis.A large, international, multicenter, population-based cohort study was conducted using combined health records from 7 participating sites in Canada, United States, Kingdom. An overall 532 513...
<h3>Background</h3> Despite their favourable toxicology profile, benzodiazepines and the related Z-drugs (zopiclone, zolpidem zaleplon) have been associated with physiological tolerance, dependence addiction. Evidence of harm (e.g., falls, motor vehicle collisions cognitive disturbances) has reported in older populations. The aim this study was to determine relation between users' characteristics use Manitoba over a 16-year period. <h3>Methods</h3> This time-series analysis based on...
Few studies have examined how the absolute risk of thromboembolism with COVID-19 has evolved over time across different countries. Researchers from European Medicines Agency, Health Canada, and United States (US) Food Drug Administration established a collaboration to evaluate arterial (ATE) venous (VTE) in 90 days after diagnosis ambulatory (eg, outpatient, emergency department, nursing facility) setting seven countries North America (Canada, US) Europe (England, Germany, Italy,...
Objective: To describe the extent of increase in use and rate continuation versus discontinuation psychotropic agents before, during, after pregnancy. Methods: Rates (antidepressants, anxiolytic/sedative-hypnotics, antiepileptics, antipsychotics, lithium, stimulants) among women with a hospital-recorded pregnancy outcome were assessed using databases at Manitoba Centre for Health Policy. Rate was defined as ≥1 prescription over total number pregnancies 3-12 months before pregnancy, 0-3...
Objective: “Antibenzodiazepine” campaigns have been conducted worldwide to limit the prescribing of these drugs because concerns about inappropriate use and addiction. The causal relationship between long-term escalation high doses has not proven. This study assessed extent dose among individuals who were users benzodiazepines or Z-hypnotics. Methods: A population-based was in Canadian province Manitoba using administrative health databases. Sustained defined as continuous for at least two...
OBJECTIVE. Antibiotics are not recommended for the treatment of wheezing in children with asthma, but little is known about their use. This study was undertaken to evaluate trends and determinants antibiotic use during fiscal years 1995 through 2001. METHODS. Using population-based health care prescription databases Manitoba, Canada, this descriptive examined time episodes a population asthma. The likelihood receiving an according child physician characteristics also determined. Annual rates...
ObjectivesThe United States Food & Drug Administration released an advisory in 2016 that fluoroquinolones be relegated to second-line agents for uncomplicated urinary tract infections (UTIs) given reports of rare but serious side effects; similar warnings have followed from Health Canada and the European Medicines Agency. The objective was determine whether alternative non-fluoroquinolone are as effective treatment UTIs.MethodsWe conducted a retrospective population-based cohort study using...
We aimed to describe medication use in pregnancies that resulted births and abortions, as well after a pregnancy-related visit characterize the receipt of knowledge pregnancy. Abortions included both spontaneous induced abortions. Rates among women with pregnancy outcome (2001–2013) were described using Manitoba Population Research Data Repository at Centre for Health Policy. Use was determined ≥ 1 prescription filled during (livebirth/stillbirth) calculated any time visit. additionally...
To determine whether patients with allergic rhinitis have altered FoxP3 gene expression and/or mutations.We collected nasal secretions from 14 volunteers (five of whom rhinitis) and five ENT allergy patients. Total RNA was isolated these secretions. The levels were quantified by both semi-quantitative RT-PCR real-time PCR using Actin as a housekeeping gene. cDNA fragments amplified analyzed DNA sequencing.We found that had significantly lower mRNA compared to nonallergic controls (P < 0.01)....
Objectives. This study examined preventive care delivered in Manitoba during the 1990s by 3 different methods —childhood immunizations (by physicians and public health nurses under a government program), screening mammography (through program introduced 1995), cervical cancer (no program). Methods. Longitudinal administrative data, an immunization monitoring system, Canadian census databases were used. Results. Cervical rates remained static showed strong socioeconomic differences; childhood...
OBJECTIVES: To determine if in utero selective serotonin reuptake inhibitor (SSRI) or norepinephrine (SNRI) exposure is associated with developmental vulnerability kindergarten among children whose mothers were diagnosed prenatal mood anxiety disorder. METHODS: Linkable administrative data used to create a population-based cohort of 266 479 mother-child dyads born Manitoba, Canada, between 1996 and 2014, follow-up through 2015. The sample was restricted who had disorder diagnosis 90 days...
Background. Psychotropic medications, in particular second-generation antipsychotics (SGAs) and benzodiazepines, have been associated with harm elderly populations. Health agencies around the world issued warnings about risks of prescribing such medications to frail individuals affected by dementia current guidelines recommend their use only cases where benefits clearly outweigh risks. This study documents psychotropic entire population a Canadian province context clinical for treatment...
Opioid use has increased dramatically in North America. The safety of opioids pregnancy is uncertain, but they are associated with several fetal abnormalities and contribute to rising rates neonatal abstinence syndrome. We examined opioid before during a complete population-based cohort.We cohort all pregnant women Manitoba, Canada, from 2001 2013. was defined by prescriptions for opioids, converted oral morphine equivalents (MEQ), the 3 months each trimester. Given that exposure per person...
To use the Canadian Network for Observational Drug Effect Studies (CNODES) to describe drug utilization of antidiabetic medications in four provinces.With data from CNODES, we constructed cohorts patients with type 2 diabetes provinces (Manitoba, Ontario, Quebec, and Saskatchewan) who received their first-ever prescription a noninsulin medication during study period, defined as earliest date availability each province (range: 1993-1998) latest extraction 2013-2014). Prescriptions rates were...
Objective: Generic drugs are less expensive than their branded equivalents, but receive limited promotion. This study sought to examine how user rates of individual selective serotonin reuptake inhibitors (SSRIs) changed after the introduction generic equivalents. Method: Administrative health and census data were used use all 6 SSRIs from 1996 2009 in province Manitoba (population 1.2 million). The primary outcome measure was a comparison pre- post-generic periods, using generalized...
Accurate coding of diagnoses SARS-CoV-2 infection in administrative data benefits population-based studies about the epidemiology, treatment and outcomes COVID-19. We describe validity recorded hospital discharge abstracts, emergency department records outpatient physician service claims from 3 Canadian provinces.
Abstract Background Serious adverse effects of fluoroquinolone antibiotics have been described for more than decade. Recently, several drug regulatory agencies advised restricting their use in milder infections which other treatments are available, given the potential disabling and possibly persistent side effects. We aimed to describe variations initial treatment urinary tract infection (UTI), acute bacterial sinusitis (ABS), exacerbation chronic obstructive pulmonary disease (AECOPD)...
Medication use is recognized as the least expensive, most cost-effective health care intervention. In older adults this especially important, they are largest consumer of prescription medications. We describe a linked data set including pharmaceutical, medical, and hospital claims to examine pharmaceutical in population then give several examples its application. Indicators population's overall medication appropriate specific have been developed. characterized using dispensation...