A5041935340- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Mobile Health and mHealth Applications
- Chronic Disease Management Strategies
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- interferon and immune responses
- Health Promotion and Cardiovascular Prevention
- Inhalation and Respiratory Drug Delivery
- Nursing Diagnosis and Documentation
- Plant Toxicity and Pharmacological Properties
- Delphi Technique in Research
- Cancer, Lipids, and Metabolism
- Plant-derived Lignans Synthesis and Bioactivity
- Medical Coding and Health Information
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginseng Biological Effects and Applications
- Family and Patient Care in Intensive Care Units
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Southampton
2008-2022
Portsmouth Hospitals NHS Trust
2015-2022
Southampton General Hospital
2015-2019
Queen Alexandra Hospital
2017-2019
University Hospital Southampton NHS Foundation Trust
2014-2015
Alder Hey Children's Hospital
1981
University of Liverpool
1981
University of Otago
1975
Critical Art and Media Practice
1975
Royal College of General Practitioners
1975
The British Thoracic Society (BTS) Home Oxygen Guideline provides detailed evidence-based guidance for the use of home oxygen patients out hospital. Although majority evidence comes from in with chronic obstructive pulmonary disease, scope includes a variety long-term respiratory illnesses and other groups whom is currently ordered, such as those cardiac failure, cancer end-stage cardiorespiratory terminal illness or cluster headache. It explores base different modalities therapy...
Objective To obtain evidence whether the online pulmonary rehabilitation(PR) programme ‘my-PR’ is non-inferior to a conventional face-to-face PR in improving physical performance and symptom scores patients with COPD. Design A two-arm parallel single-blind, randomised controlled trial. Setting The arm carried out rehabilitation their own homes face local facility. Participants 90 diagnosis of chronic obstructive disease (COPD), modified Medical Research Council score 2 or greater referred...
<h3>Background</h3> The aetiology of acute exacerbations COPD (AECOPD) is incompletely understood. Understanding the relationship between chronic bacterial airway infection and viral exposure may explain incidence seasonality these events. <h3>Methods</h3> In this prospective, observational cohort study (NCT01360398), patients with aged 40–85 years underwent sputum sampling monthly at exacerbation for detection bacteria viruses. Results are presented subjects in full cohort, followed 1 year....
<h3>Background</h3> Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and drive tissue remodelling, key processes in pathogenesis of COPD. The development small airway disease has been identified as a critical mechanism early airflow obstruction but contribution MMPs human is poorly characterised. <h3>Objectives</h3> We investigated role inflammatory cytokines lung by quantifying levels determining relationships with pathological components...
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts response to treatment, especially corticosteroids. We studied the nature of eosinophilic COPD prospectively examine stability this phenotype and its dynamics across exacerbations, associations with clinical phenotype, exacerbations infection.127 patients aged 40-85 years moderate very severe underwent repeated blood sputum sampling at stable visits within 72 h exacerbation for 1 year.Blood eosinophils ≥2% was...
Exacerbations of COPD are one the commonest causes admission and readmission to hospital. The role digital interventions support self-management in improving outcomes is uncertain. We conducted an open, randomised controlled trial a health platform application (app) 41 patients recruited following hospital with acute exacerbation. Subjects were either receive usual care, including written plan (n = 21), or myCOPD app 20) for 90 days. primary efficacy outcome was recovery rate symptoms...
COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects pathology and poorly related to clinical outcome, so other tools are required investigate the disease. We sought explore relationships between quantitative CT analysis with functional, inflammatory infective assessments identify utility imaging stratify better predict outcomes response. Patients from AERIS study moderate-very severe...
Emphysema is characterised by distinct pathological sub-types, but little known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade extracellular matrix and have been identified as potentially important in development of emphysema. However, relationship between MMPs emphysema sub-type unknown. We investigated role their inhibitors sub-types quantifying levels determining relationships with these mild-moderate COPD patients...
COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies pneumonia in focused on hospitalised and are not representative the ambulant population. Therefore, we sought to determine incidence aetiology acute exacerbation events evidence pneumonic radiographic infiltrates an outpatient cohort. One hundred twenty-seven moderate very severe aged 42–85...
The association between exacerbation aetiology and frequency is poorly understood. We analysed 2-year follow-up data from a prospective observational study of patients with chronic obstructive pulmonary disease (COPD) ( www.clinicaltrials.gov identifier number NCT01360398 ) to evaluate year-to-year variation in related aetiology. A total 127 underwent blood sputum sampling monthly at detect respiratory infections eosinophilic inflammation; 103 continued into year 2 88 completed both years....
The aetiology of acute exacerbations chronic obstructive pulmonary disease (COPD) remains incompletely understood and strategies for treatment prevention have not altered significantly many years. Improved understanding the role respiratory pathogens in COPD (AECOPD) is required use molecular microbiological techniques may lead to insights into host-pathogen interactions development more targeted therapeutic approaches.Acute Exacerbation Respiratory InfectionS (AERIS) a longitudinal...
The British Lung Foundation highlighted Southampton City as a hotspot for patients at future risk of chronic obstructive pulmonary disease (COPD) exacerbations due to severe deprivation levels and high undiagnosed level based on health economic modelling. We developed strategy spanning primary secondary care reduce emergency admissions with acute COPD increase the diagnosed prevalence general practitioner (GP) registers closer that predicted from local A comprehensive 3-year audit was...
Abstract H. haemolyticus is often misidentified as NTHi due to their close phylogenetic relationship. Differentiating between the two important for correct identification and appropriate treatment of infective organism ensure any role in disease not being overlooked. Speciation however completely reliable by culture PCR methods loss haemolysis heterogeneity NTHi. Haemophilus isolates from COPD part AERIS study (ClinicalTrials - NCT01360398) were speciated analysing sequence data presence...
<h3>Background</h3> Exacerbations of COPD are one the commonest causes admission to hospital in UK. Re-admission is also a significant problem and currently fifth most common cause hospitalisation. Self-management interventions have shown benefits improving health related quality life reducing admissions. We explored potential for an online self-management system improve outcomes patients recently admitted with exacerbation. <h3>Methods</h3> conducted feasibility randomised controlled trial...
Cancer Research
Bacterial infections are associated with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the mechanism is incompletely understood. In a COPD observational study (NCT01360398), sputum samples were collected monthly at stable state and exacerbation. Post-hoc analyses 1307 non-typeable Haemophilus influenzae (NTHi) isolates from 20 patients 756 Moraxella catarrhalis 38 in one year follow-up conducted by multilocus sequence typing (MLST). All came cultured that...
<h3>Background</h3> Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterised by an acute worsening symptoms beyond the normal day-to-day variability. Pneumonic episodes, confirmed new chest X-ray (CXR) infiltrates, common in patients with COPD but difficult to distinguish primary care from non-pneumonic exacerbations. It is uncertain whether AECOPD and pneumonic episodes distinct clinical events terms aetiology and/or response oral therapy. We performed a...
<h3>Background</h3> Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have not yet been approved for clinical cancer treatment due, in part, to poor understanding of molecular determinants on statin sensitivity. Here, we investigated the potential elicit enhanced immunogenicity <i>KRAS</i>-mutant (<i>KRAS</i><sup>mut</sup>) tumors. <h3>Methods</h3> The treated cells was determined...
<h3>Introduction</h3> Acute exacerbations of COPD have a major impact on patients’ health related quality life (HRQoL), and the utilisation care resources. Current guidelines recommend oral corticosteroids and/or antibiotics for treatment acute based symptoms. With increasing bacterial resistance to rising costs treatment, further research into diagnostic tools aid management in its stable exacerbating states is required. Sputum colour (SC) an accessible marker underlying bronchial...
<h3>Introduction</h3> COPD is a heterogeneous condition consisting of number different clinico-pathological subgroups (phenotypes), leading to particular challenges in managing the condition. Recognising these phenotypes may assist directing choice treatment options. CT being investigated as tool for identifying key morphological features seen COPD. Computer analysis scans allows quantification emphysema, bronchial wall thickening and gas trapping offers opportunity study heterogeneity This...