Angel Wong
A5007512805- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Dermatology and Skin Diseases
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Chronic Disease Management Strategies
- Gastric Cancer Management and Outcomes
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacovigilance and Adverse Drug Reactions
- Influenza Virus Research Studies
- Venous Thromboembolism Diagnosis and Management
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Frailty in Older Adults
- Gastroesophageal reflux and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health and Medical Studies
- Health disparities and outcomes
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Asthma and respiratory diseases
- Climate Change and Health Impacts
London School of Hygiene & Tropical Medicine
2018-2025
Hong Kong Science and Technology Parks Corporation
2024
University of London
2020-2024
University of Tsukuba
2020-2024
Lake Erie College of Osteopathic Medicine
2023-2024
Laboratory of Data Discovery for Health
2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
University of Leicester
2021
Chinese University of Hong Kong
2021
Abstract Background Establishing who is at risk from a novel rapidly arising cause of death, and why, requires new approach to epidemiological research with very large datasets timely data. Working on behalf NHS England we therefore set out deliver secure pseudonymised analytics platform inside the data centre major primary care electronic health records vendor establishing coverage across detailed for substantial proportion all patients in England. The following results are preliminary....
<h2>Summary</h2><h3>Background</h3> COVID-19 has disproportionately affected minority ethnic populations in the UK. Our aim was to quantify differences SARS-CoV-2 infection and outcomes during first second waves of pandemic England. <h3>Methods</h3> We conducted an observational cohort study adults (aged ≥18 years) registered with primary care practices England for whom electronic health records were available through OpenSAFELY platform, who had at least 1 year continuous registration start...
Abstract The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden possible causes in community, we coordinated analyses survey data from 6907 self-reported COVID-19 10 UK longitudinal study (LS) samples 1.1 million diagnostic codes electronic healthcare records (EHR) collected by spring 2021. Proportions presumed cases LS reporting any symptoms for 12+ weeks ranged 7.8% 17% (with 1.2 to 4.8%...
Objective Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy, particularly in Helicobacter pylori (HP)-infected subjects. We determined the association between PPIs use and cancer (GC) among HP-infected subjects who had received HP therapy. Designs This study was based on a territory-wide health database Hong Kong. identified adults an outpatient prescription clarithromycin-based triple therapy year 2003 2012. Patients failed this regimen, those diagnosed to have...
BackgroundThere are concerns that the response to COVID-19 pandemic in UK might have worsened physical and mental health, reduced use of health services. However, scale problem is unquantified, impeding development effective mitigations. We aimed ascertain what has happened general practice contacts for acute outcomes during pandemic.MethodsUsing de-identified electronic records from Clinical Research Practice Datalink (CPRD) Aurum (covering 13% population), between 2017 2020, we calculated...
<b>Study question</b> What is the association between clarithromycin use and cardiovascular outcomes? <b>Methods</b> In this population based study authors compared outcomes in adults aged 18 or more receiving oral amoxicillin during 2005-09 Hong Kong. Based on age within five years, sex, calendar year at use, each user was matched to one two users. The cohort analysis included patients who received (n=108 988) (n=217 793). self controlled case series crossover those...
The risk of severe COVID-19 outcomes in people with immune-mediated inflammatory diseases and on immune-modifying drugs might not be fully mediated by comorbidities vary factors such as ethnicity. We aimed to assess the adults those therapies.
Abstract Objective To assess the association between learning disability and risk of hospital admission death from covid-19 in England among adults children. Design Population based cohort study on behalf NHS using OpenSAFELY platform. Setting Patient level data were obtained for more than 17 million people registered with a general practice that uses TPP software. Electronic health records linked Office National Statistics Secondary Uses Service. Participants Adults (aged 16-105 years)...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha variant (B.1.1.7) is associated with higher transmissibility than wild-type virus, becoming the dominant in England by January 2021. We aimed to describe severity of terms pathway disease from testing positive hospital admission and death. Methods With approval NHS England, we linked individual-level data primary care SARS-CoV-2 community testing, admission, Office for National Statistics all-cause...
Abstract Objective To investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes disease 2019 (covid-19) differed between adults living without children during the first two waves UK pandemic. Design Population based cohort study, on behalf NHS England. Setting Primary care data pseudonymously linked hospital intensive admissions death records from England, wave 1 (1 February to 31 August 2020) September 18 December 2020)....
Background There is concern about medium to long-term adverse outcomes following acute Coronavirus Disease 2019 (COVID-19), but little relevant evidence exists. We aimed investigate whether risks of hospital admission and death, overall by specific cause, are raised discharge from a COVID-19 hospitalisation. Methods findings With the approval NHS-England, we conducted cohort study, using linked primary care data in OpenSAFELY compare between people discharged hospitalisation (February...
Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies found no evidence reduced mortality when treating patients with COVID-19. We aimed evaluate the effectiveness hydroxychloroquine for prevention COVID-19 mortality, as opposed treatment disease.
Although prior studies showed metformin could reduce gastric cancer (GC) risk in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and glycemic control. We aimed investigate whether reduced GC H. pylori-eradicated diabetic its association This was a territory-wide cohort study using hospital registry database, recruiting all who were prescribed clarithromycin-based triple therapy from 2003 2012. Subjects observed prescription until diagnosis, death, or...
Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases risk stimulation increases risk. Establishing baseline in people is important before exploring the association new biologic drugs for risk.To investigate whether associated cancer.Matched cohort studies were conducted from January 2, 1998, to March 31, 2016, England 1, 1982, June 30, Denmark. We our analyses July 2018 2019. The setting was English primary care...
To access temporal changes in psychobehavioral responses to the coronavirus disease (COVID-19) pandemic, we conducted a 5-round (R1-R5) longitudinal population-based online survey Hong Kong during January-September 2020. Most respondents reported wearing masks (R1 99.0% R5 99.8%) and performing hand hygiene 95.8% 97.7%). Perceived COVID-19 severity decreased significantly, from 97.4% (R1) 77.2% (R5), but perceived self-susceptibility remained high (87.2%-92.8%). Female sex anxiety were...
Despite successful H. pylori (HP) eradication, some individuals remain at risk of developing gastric cancer (GC). Previous studies showed that aspirin was associated with a reduced GC risk. However, whether can reduce in HP-eradicated subjects remains unknown. We aimed to determine the chemopreventive effect subjects.We identified who had received prescription clarithromycin-based triple therapy for HP between 2003 and 2012 from territory-wide health care database. The observation period...
Abstract Background Characterising the size and distribution of population at risk severe COVID-19 is vital for effective policy planning. Older age, underlying health conditions, are associated with higher death from COVID-19. This study aimed to describe due conditions across United Kingdom. Methods We used anonymised electronic records Clinical Practice Research Datalink GOLD estimate point prevalence on 5 March 2019 at-risk following national guidance. Prevalence any condition each...
Objective The aim of this study was to investigate the association between oral anticoagulant type (direct anticoagulants (DOACs) vs vitamin K antagonists (VKAs)) and incident dementia or mild cognitive impairment (MCI) among patients with newly diagnosed atrial fibrillation (AF). Methods Using linked electronic health record (EHR) data from Clinical Practice Research Datalink in UK, we conducted a historical cohort first-time users non-valvular AF 2012 2018. We compared incidence (1)...