Colm Andrews
A5069226602- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Retinal Diseases and Treatments
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- Telemedicine and Telehealth Implementation
- Global Cancer Incidence and Screening
- Retinal and Optic Conditions
- Rheumatoid Arthritis Research and Therapies
- Chronic Disease Management Strategies
- Intensive Care Unit Cognitive Disorders
- Climate Change and Health Impacts
- Genetic Associations and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Emergency and Acute Care Studies
- Healthcare Systems and Challenges
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- COVID-19 epidemiological studies
- Cardiac Health and Mental Health
- Spondyloarthritis Studies and Treatments
University of Oxford
2017-2025
Oxford University Hospitals NHS Trust
2018-2025
Royal Marsden NHS Foundation Trust
2024
Institute of Cancer Research
2024
National Health Service
2024
Nuffield Health
2022-2024
Science Oxford
2024
Bennett University
2023
Medical Research Council
2023
UK Research and Innovation
2023
The Oxford WebQ is a web-based 24-h dietary assessment method which has been used in UK Biobank and other large prospective studies. food composition table to calculate nutrient intakes recently replaced with the Nutrient Databank, data closer time when participants completed questionnaire, new variables were incorporated. Here we describe updated version of questionnaire calculation, compare previous used.207,144 ≥ 1 WebQs, means standard deviations averaged for all assessments. Spearman...
<ns4:p><ns4:bold>Background:</ns4:bold> Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to global COVID-19 emergency. is derived practices England using SystmOne software, and majority of these studies. We set out investigate representativeness by comparing it national population estimates. </ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>With approval NHS England, we describe age, sex, Index...
Abstract Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, association genetically predicted is not known. We investigated calculated free and measured total sex hormone‐binding globulin (SHBG) aggressive, overall early‐onset prostate cancer. In blood‐based analyses, odds ratios (OR) 95% confidence intervals (CI) for cancer were estimated using conditional logistic regression from prospective analysis...
Abstract Background Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, association genetically predicted IGF-I aggressive is not known. We aimed investigate IGF-I, IGF-II, IGFBP-1, IGFBP-2 IGFBP-3 concentrations overall, early-onset cancer. Methods Prospective analysis biomarkers using Endogenous Hormones, Nutritional Biomarkers...
Abstract Objective To compare the effectiveness of BNT162b2 mRNA (Pfizer-BioNTech) and mRNA-1273 (Moderna) covid-19 vaccines during booster programme in England. Design Matched cohort study, emulating a comparative trial. Setting Linked primary care, hospital, surveillance records available within OpenSAFELY-TPP research platform, covering period when SARS-CoV-2 delta omicron variants were dominant. Participants 3 237 918 adults who received dose either vaccine between 29 October 2021 25...
Some studies have shown that the incidence of type 2 diabetes increases after a diagnosis COVID-19, although evidence is not conclusive. However, effects COVID-19 vaccine on this association, or effect other subtypes, are clear. We aimed to investigate association between and 2, 1, gestational non-specific diabetes, COVID- 19 vaccination, up 52 weeks diagnosis.
To ascertain patient eligibility status and describe coverage of antiviral drugs neutralising monoclonal antibodies (nMAB) as treatment for covid-19 in community settings England.Retrospective, descriptive cohort study, approved by NHS England.Routine clinical data from 23.4 million people linked to on infection treatment, within the OpenSAFELY-TPP database.Outpatients with at high risk severe outcomes.Nirmatrelvir/ritonavir (paxlovid), sotrovimab, molnupiravir, casirivimab/imdevimab, or...
Abstract Background While the vaccines against COVID-19 are highly effective, vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing characteristics of individuals who have experienced breakthroughs could be hugely important in helping to determine may at greatest risk. Methods approval NHS England, we conducted a retrospective cohort study using routine clinical data from OpenSAFELY-TPP database vaccinated individuals, linked...
Electronic health records (EHRs) and other administrative data are increasingly used in research to generate evidence on the effectiveness, safety, utilisation of medical products services, inform public guidance policy. Reproducibility is a fundamental step for credibility promotes trust generated from EHRs. At present, ensuring using EHRs reproducible can be challenging researchers. Research software platforms provide technical solutions enhance reproducibility conducted In response...
Associations have been found between COVID-19 and subsequent mental illness in both hospital- population-based studies. However, evidence regarding which illnesses are associated with by vaccination status these populations is limited.
Background/Aim To report the efficacy and tolerability of antitumour necrosis factor-alpha therapy (TNF inhibitors [TNFi]) in management non-infectious ocular inflammation, including uveitis scleritis, adult patients over an 8-year period. Materials methods This is a prospective cohort study infliximab adalimumab treatment inflammatory disease. 43 85 on TNFi (34 infliximab, 9 adalimumab) for ≥1 year with or scleritis were followed from 2006 to 2014. Clinical assessments, medication, adverse...
Healthcare across all sectors, in the UK and globally, was negatively affected by COVID-19 pandemic. We analysed healthcare services delivered to people with pancreatic cancer from January 2015 March 2023 investigate effect of
Purpose: To characterize dark adaptation in patients with pseudoxanthoma elasticum, a systemic disease leading to calcification of elastic tissue including the Bruch membrane. Methods: In this prospective case–control study, thresholds were measured using Goldmann-Weekers adaptometer. Additional assessments included best-corrected visual acuity testing, contrast sensitivity, low luminance deficit, and vision-related quality life. Results: Dark significantly higher, periods prolonged...
Background The COVID-19 pandemic affected how care was delivered to vulnerable patients, such as those with dementia or learning disability. Objective To explore whether this antipsychotic prescribing in at-risk populations. Methods With the approval of NHS England, we completed a retrospective cohort study, using OpenSAFELY platform primary data 59 million patients. We identified patients five groups: autism, dementia, disability, serious mental illness and home residents. calculated...
Background COVID-19 restrictions led to increased reports of depressive symptoms in the general population and impacted health social care services. We explored whether these changes affected antidepressant prescribing trends those with learning disability or autism. Methods With approval NHS England, we used >24 million patients’ primary data from OpenSAFELY-TPP platform. interrupted time series analysis quantify prescribed newly an across key demographic clinical subgroups, comparing...
Although prostate cancer is a leading cause of death, its aetiology not well understood. We aimed to identify novel biochemical factors for incidence and mortality in UK Biobank.
The COVID-19 pandemic disrupted health-care delivery, including difficulty accessing in-person care, which could have increased the need for strong pharmacological pain relief. Due to risks associated with overprescribing of opioids, especially vulnerable populations, we aimed quantify changes measures during pandemic, overall, and by key subgroups.
Abstract Purpose To investigate the impact of central serous chorioretinopathy on sleep and mood in patients with acute chronic chorioretinopathy. Methods This cross-sectional study compared differences between control recruited from Ophthalmology clinics at John Radcliffe Hospital, Oxford 2012 2020. Data including visual acuity, type (acute or chronic; aCSC/cCSC), sex, chronotype were obtained. Sleep quality was measured using Pittsburgh Quality Index (PSQI); Hospital Anxiety Depression...
Background NHS England guidance was issued in November 2020 for use of COVID Oximetry @home (informally named CO@h) to detect early deterioration patients with COVID-19 primary and community care settings. Methods With the approval we conducted a retrospective cohort study between 4th October 10th July 2021, using records 57 million people registered at an English general practice. We identified pulse oximetry coding (either specific CO@H codes or non-specific COPD005 codes) described their...
<sec> <title>BACKGROUND</title> NHS England guidance was issued in November 2020 for use of COVID Oximetry @home (informally named CO@h) to detect early deterioration patients with COVID-19 primary and community care settings. </sec> <title>OBJECTIVE</title> We set out describe the SNOMED CT codes used represent service during outbreak, broken down by patient demographics, clinical characteristics, where possible their eligibility CO@h. <title>METHODS</title> With approval we conducted a...