A5013574385- Palliative and Oncologic Care
- Palliative Care and End-of-Life Issues
- COVID-19 Clinical Research Studies
- Ethics and bioethics in healthcare
- Health, Environment, Cognitive Aging
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Patient Dignity and Privacy
- SARS-CoV-2 and COVID-19 Research
- Health disparities and outcomes
- Diet and metabolism studies
- SARS-CoV-2 detection and testing
- Family and Patient Care in Intensive Care Units
- Ethics in medical practice
- COVID-19 epidemiological studies
- Nursing care and research
- Gut microbiota and health
- Suicide and Self-Harm Studies
- Aging, Health, and Disability
- Psychosomatic Disorders and Their Treatments
- Muscle metabolism and nutrition
- Optimism, Hope, and Well-being
- Biological Research and Disease Studies
- Educational Practices and Policies
- Fish biology, ecology, and behavior
King's College London
2020-2025
Universidad de Ingeniería y Tecnología
2022
St Thomas' Hospital
2021
Universidad de Granada
2016-2019
University of Cambridge
2017
Universidad Complutense de Madrid
2016
Pontificia Universidad Católica de Chile
2015
Abstract Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut play a role in anabolic resistance of older muscle, cognition. In this placebo controlled double blinded randomised trial 36 twin pairs (72 individuals), aged ≥60, each pair are block to receive either or prebiotic daily for 12 weeks. Resistance exercise branched chain amino acid (BCAA) supplementation is prescribed all participants. Outcomes physical function The...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher anti-Spike antibodies are known associated with increased protection against However, variation in factors for lower each round vaccination have not been explored across a wide range socio-demographic, health within population-based cohorts.
Some studies have shown that the incidence of type 2 diabetes increases after a diagnosis COVID-19, although evidence is not conclusive. However, effects COVID-19 vaccine on this association, or effect other subtypes, are clear. We aimed to investigate association between and 2, 1, gestational non-specific diabetes, COVID- 19 vaccination, up 52 weeks diagnosis.
Abstract Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In humans, positive selection driver mutations during spermatogenesis is known increase birth prevalence certain developmental disorders. Until recently, characterising extent this has been limited by error rates sequencing technologies. Using duplex method NanoSeq, we sequenced 81 bulk samples from individuals aged 24 75 years. Our findings revealed a linear accumulation 1.67 (95% CI =...
Introduction Social gradients in COVID-19 exposure and severity have been observed internationally. Whether combinations of pre-existing social factors, particularly those that confer cumulative advantage disadvantage, affect recovery from ongoing symptoms following long COVID is less well understood. Methods We analysed data on self-perceived self-reported illness two UK community-based cohorts, Symptom Study Biobank (CSSB) (N=2548) TwinsUK (N=1334). Causal effects sociodemographic...
Abstract Background Loss of skeletal muscle mass and strength occurs with increasing age is associated loss function, disability, the development sarcopenia frailty. Dietary protein essential for but older adults do not anabolise in response to supplementation as well younger people, so called ‘anabolic resistance’. The aetiology molecular mechanisms this are understood, however gut microbiome known play a key role several proposed mechanisms. Thus, we hypothesise that may mediate anabolic...
Undergraduate students are increasingly working with academic staff to evaluate and design teaching materials in Higher Education, thereby moving from being passive consumers of knowledge genuine partners their education. Here we describe a student partnership project run at the University Cambridge, which aimed improve undergraduate biology practical class teaching. Student interns were recruited act as researchers, pedagogical consultants producers resources. Research by revealed that...
<ns4:p>TwinsUK is a population-based study which consists of 14,575 adult twins at present (55% monozygotic and 43% dizygotic) who are between 18 to 101 years age from around the United Kingdom (UK). In response coronavirus disease 2019 (COVID-19) pandemic resulting UK ‘lockdown’ restrictions, our team developed TwinsUK COVID-19 personal experience (CoPE) questionnaire. To date CoPE questionnaire has been implemented three times, once during first lockdown (April-May 2020), as restrictions...
The emergence of the new COVID-19 virus in Peru forced Peruvian government to take swift measures stop its proliferation. Consequently, a state emergency was declared, which included mandatory social isolation and quarantine. This action meant that people would transit only cases. In this context, study’s objective is analyze air quality changes terms capital city’s NO2 levels due these decisions using satellite imagery data obtained from Sentinel-5P satellite. One critical problem lack...
Abstract Background Predicting the likely size of future SARS-CoV-2 waves is necessary for public health planning. In England, voluntary “plan B” mitigation measures were introduced in December 2021 including increased home working and face coverings shops but stopped short restrictions on social contacts. The impact risk behaviours burden unknown. Methods We developed a rapid online survey ahead winter festive period deployed two longitudinal cohort studies UK (Avon Longitudinal Study...
Purpose MRI can produce quantitative liver fat fraction (FF) maps noninvasively, which help to improve diagnoses of fatty diseases. However, most sequences acquire several two‐dimensional (2D) slices during one or more breath‐holds, may be difficult for patients with limited breath‐holding capacity. A whole‐liver 3D FF map could also obtained in a single acquisition by applying reliable breathing‐motion correction method. Several techniques are available imaging, but they use external...
Abstract Background Longitudinal cohort studies are pivotal to understand how socioeconomic, environmental, biological, and lifestyle factors influence health disease. The added value of increases as they accumulate life course data expand across generations. Ensuring that participants stay motivated contribute over decades follow-up is, however, challenging. Participant engagement involvement (PEI) aims secure the long-term commitment promote researcher-participant interaction. This study...
The COVID-19 pandemic disrupted healthcare and may have impacted ethnic inequalities in healthcare. We aimed to describe the impact of pandemic-related disruption on differences clinical monitoring hospital admissions for non-COVID conditions England.
ABSTRACT The cardia bifida in amphibians has the bulboventricular loop of two hemi-hearts convex towards mid-line. In birds loops have been reported to be outside because all experimental methods producing birds, unlike amphibians, impede closure foregut. morphologic expression each cardiac primordium was studied without altering endodermal tubulation or it only least possible degree. It demonstrated that mid-line and heart formed by one also tend Previous studies confirmed sense caudal...
Objetivos: Conocer cómo se produce el encuentro clínico en la atención a los enfermos por parte de un equipo Cuidados Paliativos, y qué elementos lo condicionan, indicando si son favorables o desfavorables función las expectativas sentimientos distintos participantes. Método: Estudio casos cualitativo, realizado mediante observación participante. Se realizaron 12 observaciones encuentros equipos cuidados paliativos con pacientes familiares diferentes entornos (domicilio, hospital consulta)....
Abstract Background The Omicron variant of SARS-CoV-2 infection poses substantial challenges to public health. In England, “plan B” mitigation measures were introduced in December 2021 including increased home working and face coverings shops, but stopped short restrictions on social contacts. impact voluntary risk behaviours future burden is unknown. Methods We developed a rapid online survey during the winter festive period deployed two longitudinal cohort studies UK (Avon Longitudinal...
Abstract SARS-CoV-2 antibody levels can be used to assess humoral immune responses following infection or vaccination, and may predict risk of future infection. From cross-sectional testing 9,361 individuals from TwinsUK ALSPAC UK population-based longitudinal studies (jointly in April-May 2021, only November 2021-January 2022), we tested associations between vaccination and: (1) vaccination(s); (2) health, socio-demographic, variables. Within TwinsUK, single-vaccinated with the lowest 20%...