A5039181987- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Health disparities and outcomes
- Child Nutrition and Water Access
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Chronic Disease Management Strategies
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Respiratory Health Research
- Child and Adolescent Health
- COVID-19 and Mental Health
- Air Quality and Health Impacts
- Geriatric Care and Nursing Homes
- Breastfeeding Practices and Influences
- COVID-19 and healthcare impacts
- Global Health Care Issues
- Nutritional Studies and Diet
- Stroke Rehabilitation and Recovery
- Cardiac, Anesthesia and Surgical Outcomes
- Obesity and Health Practices
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
Bradford Teaching Hospitals NHS Foundation Trust
2014-2025
University of Bradford
2017-2025
Bradford Royal Infirmary
2016-2025
University of Bristol
2024
MRC Epidemiology Unit
2024
National Health Service
2023-2024
Johns Hopkins University
2022
Berkeley Public Health Division
2022
University of California, Berkeley
2022
Victoria University of Wellington
2020
BackgroundDiagnosis of gestational diabetes predicts risk infants who are large for age (LGA) and with high adiposity, which in turn aims to predict a future obesity the offspring. South Asian women have higher diabetes, lower LGA, on average give birth greater adiposity than do white European women. Whether same diagnostic criteria should apply both groups is unclear. We aimed assess association between maternal glucose adverse perinatal outcomes ascertain whether thresholds used diagnose...
Abstract Background Although maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate prevalence pre-existing multimorbidity (two or more long-term physical mental health conditions) pregnant Kingdom (England, Northern Ireland, Wales and Scotland). Study design Pregnant aged 15–49 years with a conception date 1/1/2018 31/12/2018 were included this population-based cross-sectional study, using routine healthcare datasets...
Abstract Background The number of medications prescribed during pregnancy has increased over the past few decades. Few studies have described prevalence multiple medication use among pregnant women. This study aims to describe overall last two decades all women and those with multimorbidity identify risk factors for polypharmacy in pregnancy. Methods A retrospective cohort was conducted between 2000 2019 using Clinical Practice Research Datalink (CPRD) register. Prescription records 577...
Key Features� Born in Bradford (BiB) is a multi-ethnic birth cohort Bradford, UK, which recruited 12 453 women with 13 776 pregnancies and 3448 of their partners between 2007 2011.� Routine health education data have been collected since subsamples followed up to age 5 years.Metabolomics genetic are available for �11 000 mothers �9000 children.The works closely communities providers using findings influence policy.� This update summarizes the most recent follow-up school community settings...
BackgroundDopamine is a key modulator of striatal function and learning might improve motor recovery after stroke. Previous small trials dopamine agonists stroke provide equivocal evidence effectiveness on improving recovery. We aimed to assess the safety efficacy co-careldopa plus routine occupational physical therapy during early rehabilitation stroke.MethodsThis double-blind, multicentre, randomised controlled trial versus placebo in addition NHS was done at 51 UK acute inpatient...
We investigated associations between multiple sociodemographic characteristics (sex, age, occupational social class, education and ethnicity) self-reported healthcare disruptions during the early stages of COVID-19 pandemic.Coordinated analysis prospective population surveys.Community-dwelling participants in UK April 2020 January 2021.Over 68 000 from 12 longitudinal studies.Self-reported disruption to medication access, procedures appointments.Prevalence varied substantially across...
Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics other known factors. DNA methylation is one underexplored mechanism may explain risk. Currently, there little knowledge how varies ethnicities. This study characterised blood self-reported from two UK-based cohorts: Southall Brent Revisited Born Bradford. ethnicities were widespread throughout the genome (n = 16,433...
Background Home working has increased since the Coronavirus Disease 2019 (COVID-19) pandemic’s onset with concerns that it may have adverse health implications. We assessed association between home and social mental wellbeing among employed population aged 16 to 66 through harmonised analyses of 7 UK longitudinal studies. Methods findings estimated associations measures psychological distress, low life satisfaction, poor self-rated health, contact, loneliness across 3 different stages...
The associations of exposure to air-pollutants and respiratory illness remains inconsistent studies have not adequately addressed the non-linearity delayed effects exposure. This is a retrospective cohort study using linked routine health pollution data collected between January 2018 December 2021. Participants were patients who visited General Practice (GP) or accident emergency (A&E) services for illness. Time-series analysis, distributed lagged models, was used address potential There...
Associations have been found between COVID-19 and subsequent mental illness in both hospital- population-based studies. However, evidence regarding which illnesses are associated with by vaccination status these populations is limited.
<ns3:p>Background Despite the popularity of low emissions zones (LEZ) across Europe their public acceptability and impact on travel behaviours are scarcely studied. We aimed to explore changes in acceptability, perceptions air quality, a multi-ethnic sample living Bradford, UK after implementation Clean Air Zone (a type LEZ). Methods Telephone, in-person online surveys were conducted one year pre- post implementation. Participants included members representative Born Bradford (BiB) cohort...
To determine the prevalence, types and early-life risk factors associated with strabismus in a multi-ethnic birth cohort of children aged 4-5 years first year school.Data were collected prospectively over 3-year period (2012-2015) from participating vision screening program provided by orthoptists carried out schools located city Bradford, UK. Prevalence was determined for 17,018 4 to 5 years. Data linkage undertaken 4563 Born Bradford study program. 4067 had complete data included...
Economic, physical, built, cultural, learning, social and service environments have a profound effect on lifelong health. However, policy thinking about health research is dominated by the 'biomedical model' which promotes medicalisation an emphasis diagnosis treatment at expense of prevention. Prevention has tended to focus 'downstream' interventions that rely individual behaviour change, frequently increasing inequalities. Preventive strategies often isolated leverage points are scattered...
The prevalence of infant obesity is increasing, but there a lack evidence-based approaches to prevent at this age. This study tested the acceptability and feasibility evaluating theory-based intervention aimed reducing risk in infants overweight/obese women during after pregnancy: Healthy Active Parenting Programme for Early Years (HAPPY).
Background Advancements in knowledge of obesity aetiology and mobile phone technology have created the opportunity to develop an electronic tool predict infant's risk childhood obesity. The study aims were validate equations for prediction integrate them into a application (App). Methods Findings Anthropometry data obtained 1868 UK-born White or South Asian infants Born Bradford cohort. Logistic regression was used (at 6±1.5, 9±1.5 12±1.5 months) (BMI at 2 years >91st centile weight gain...
The present study aimed to explore previously unreported ethnic differences in infant feeding practices during the introduction of solid foods, accounting for maternal and birth factors, determine whether these patterns are associated with BMI at 3 years age. An observational using Poisson regression was carried out investigate relationship between ethnicity linear used age a subsample 1327 infants Bradford. It found that compared White British mothers, mothers Other ethnicities were less...
Measuring physical activity (PA) and sedentary time (ST) in young children (<5 years) is complex. Objective measures have high validity but require specialist expertise, are expensive, can be burdensome for participants. A proxy-report instrument that accurately PA ST needed. The aim of this study was to assess the reliability Early Years Physical Activity Questionnaire (EY-PAQ). In a setting where English Urdu predominant languages spoken by parents children, sample 196 their (mean age 3.2...
Many modifiable risk factors in early infancy have been shown to be associated with childhood overweight and obesity. These not studied within children of South Asian origin the UK. The aims this paper are describe differences prevalence for obesity between White British Pakistani investigate association these BMI measured at age 3 years. We used data from a sub-study Born Bradford birth cohort detailed follow-up visits throughout childhood. 987 participants measurement were included; 39%...
To examine independent associations of sleep duration with total and abdominal adiposity, the bidirectionality these associations, in a young biethnic sample children from disadvantaged location. Child (h/day) was parent-reported by questionnaire indices (body weight, body mass index, percent fat (%BF), sum skinfolds) adiposity (waist circumference) were measured using standard anthropometric procedures at approximately 12, 18, 24, 36 months age 1,338 (58% South Asian; 42% White). Mixed...
The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application this concept to environmental-health association studies include a possibly high false-positive rate. We aimed reduce dimension using information DNA methylation way more efficiently characterize relation between and child body mass index (BMI). Among 1,173 mother–child pairs HELIX cohort, 216 ("whole exposome") were characterized. BMI immune cells...
Abstract Background The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite this, the underlying molecular mechanisms in utero and postnatal smoke are only partially understood. Here, we aimed identify multi-layer signatures associated with these two windows. Methods We investigated associations maternal during pregnancy childhood secondhand (SHS) features measured 1203 European children (mean age 8.1 years) from Human Early Life Exposome...
Abstract Background Observational studies have reported maternal short/long sleep duration to be associated with adverse pregnancy and perinatal outcomes. However, it remains unclear whether there are nonlinear causal effects. Our aim was use Mendelian randomization (MR) multivariable regression examine effects of on stillbirth (MR only), miscarriage gestational diabetes, hypertensive disorders pregnancy, depression, preterm birth low/high offspring birthweight. Methods We used data from...