A5053564047- Pregnancy and Medication Impact
- Chronic Disease Management Strategies
- Cardiovascular Issues in Pregnancy
- Health, Environment, Cognitive Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Global Maternal and Child Health
- Maternal Mental Health During Pregnancy and Postpartum
- demographic modeling and climate adaptation
- Electronic Health Records Systems
- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Machine Learning in Healthcare
- Delphi Technique in Research
- Primary Care and Health Outcomes
- Context-Aware Activity Recognition Systems
- Nursing Diagnosis and Documentation
- Prenatal Substance Exposure Effects
- Obstructive Sleep Apnea Research
- Healthcare Systems and Technology
- Healthcare Technology and Patient Monitoring
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
University of Birmingham
2020-2025
Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook retrospective matched cohort study using UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine that are confirmed SARS-CoV-2 beyond 12 weeks in non-hospitalized adults and the risk factors developing symptoms. selected 486,149 1,944,580...
Abstract Background The number of medications prescribed during pregnancy has increased over the past few decades. Few studies have described prevalence multiple medication use among pregnant women. This study aims to describe overall last two decades all women and those with multimorbidity identify risk factors for polypharmacy in pregnancy. Methods A retrospective cohort was conducted between 2000 2019 using Clinical Practice Research Datalink (CPRD) register. Prescription records 577...
<ns4:p>Background It is easy to overlook risk factors that require specific healthcare actions. This particularly true in maternity care, which deals with a natural process where might be distinguished from normality at many points the care pathway. In this paper, we describe effects of clinical decision support, first form paper checklists and then an electronic checklist screen for risks (1) venous thromboembolism (VTE), (2) intrauterine growth restriction (IUGR), (3) high body mass index...
Background Obstructive sleep apnoea syndrome (OSAS) has been recognised as a potential risk factor for cognitive decline, yet its precise relationship with dementia remains uncertain. This study aimed to determine the of among individuals and without OSAS. Methods Data derived from 2.3 million adults (aged ≥18 years) were extracted Clinical Practice Research Datalink (2000–2022), nationally representative primary care electronic health records database in UK. 193 600 OSAS propensity...
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) infection is frequently associated with a wide range of persistent symptoms, now referred to as post-COVID-19 condition, or Long COVID. The objectives this study were assess which symptoms are confirmed SARS CoV-2 beyond 12 weeks post-infection in non-hospitalised individuals, and the risk factors developing symptoms. We undertook retrospective matched cohort between 31st January 2020 15th April 2021 using data from large...
Introduction One in five pregnant women has multiple pre-existing long-term conditions the UK. Studies have shown that maternal are associated with adverse outcomes. This observational study aims to compare and child outcomes for those without (0 or 1 conditions). Methods analysis Pregnant aged 15–49 years old a conception date between 2000 2019 UK will be included follow-up till 2019. The data source routine health records from all four nations (Clinical Practice Research Datalink...
Abstract Introduction We report a pathfinder study of AI/knowledge engineering methods to rapidly formalise COVID‐19 guidelines into an executable model decision making and care pathways. The knowledge source for the was material published by BMJ Best Practice in March 2020. Methods PROforma guideline modelling language OpenClinical.net authoring publishing platform were used create data patients together with models rules, decisions plans that interpret patient give personalised advice....
Abstract Motivation Increasingly vast quantities of data support improvement and research in public health, growth is especially seen administrative such as that collected electronic health records. Patients enter exit these typically open-cohort datasets non-uniformly; this can render simple questions about incidence prevalence time-consuming with unnecessary variation between analyses. We therefore developed methods to automate analysis open cohort datasets, improve transparency,...
Abstract Introduction Birth cohorts are valuable resources for studying early life, the determinants of health, disease, and development. They essential life course. Electronic live, dynamic longitudinal using anonymised, routinely collected data. There is no selection bias through direct recruitment, but they limited to health administrative system data may lack contextual information. The MIREDA (Maternal Infant Research Data Analysis) partnership creates a UK-wide birth cohort by aligning...
Abstract Motivation Data is increasingly used for improvement and research in public health, especially administrative data such as that collected electronic health records. Patients enter exit these typically open-cohort datasets non-uniformly; this can render simple questions about incidence prevalence time-consuming with unnecessary variation between analyses. We therefore developed methods to automate analysis of open cohort datasets, improve transparency, productivity reproducibility...
IntroductionBirth cohorts are valuable resources for studying early life, the determinants of health, disease, and development. They essential life course. Dynamic longitudinal electronic use routinely collected data, live, can reduce selection bias specifically associated with direct recruitment in traditional birth cohorts. However, they limited to health administrative data may lack contextual information. The MIREDA (Mother Infant Research Electronic Data Analysis) partnership creates a...
Cardiovascular disease risk factors (CVDRF), in particular diabetes and hypertension, are chronic conditions which carry a substantial burden Low- Middle-Income Countries. Unlike HIV, they were neglected the Millenium Development Goals along with health services required to manage them. To inform level of service readiness that could be achieved increased attention, we compared for CVDRF HIV. Using data from national Service Provision Assessments, describe facility-reported provide derive...
Introduction With good medical care, most pregnancy complications like pre-eclampsia, gestational diabetes, etc resolve after childbirth. However, are known to be associated with an increased risk of new long-term health conditions for women later in life, such as cardiovascular disease. These umbrella reviews aim summarise systematic evaluating the association between and five groups conditions: autoimmune conditions, cancers, functional disorders, mental metabolic (diabetes hypertension)....
Introduction Considering the high prevalence of polypharmacy in pregnant women and knowledge gap risk–benefit safety profile their often-complex treatment plan, more research is needed to optimise prescribing. In this study, we aim detect adverse protective effect signals exposure individual pairwise combinations medications during pregnancy. Methods analysis Using a range real-world data sources from UK, conduct pharmacovigilance study assess prescribed preconception period (3 months prior...
ABSTRACT Introduction One in five pregnant women have multiple long-term conditions the United Kingdom (UK). Studies shown that maternal are associated with adverse outcomes. This observational study aims to compare and children’s outcome for those without conditions. Methods analysis Pregnant aged 15 49 years old a conception date between 2000 2019 UK will be included. The data source routine health records from all four nations (Clinical Practice Research Datalink [CPRD, England], Secure...