A5100751178- Acute Kidney Injury Research
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Chronic Kidney Disease and Diabetes
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Spinal Hematomas and Complications
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Optical Imaging and Spectroscopy Techniques
- Spine and Intervertebral Disc Pathology
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Inflammatory Biomarkers in Disease Prognosis
Princess Margaret Cancer Centre
2025
University Health Network
2025
University of Toronto
2023-2025
Tianjin Chest Hospital
2010-2024
Tianjin University
2021-2024
Weatherford College
2023
Tianjin Medical University
2011-2023
Thrombolysis in Myocardial Infarction Study Group
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2021-2022
Linyi People's Hospital
2010-2022
T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising diverse subtypes that are challenging to stratify using conventional immunophenotyping. To gain insights into subset-specific therapeutic vulnerabilities, we performed integrative multiomics analysis of bone marrow samples from newly diagnosed T cell ALL, early precursor and T/myeloid mixed phenotype leukemia. Leveraging cellular indexing transcriptomes epitopes in conjunction with receptor sequencing, identified...
Abstract Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies. Empagliflozin (EMPA) improves cardiovascular outcomes in HFpEF patients, but the underlying mechanism remains elusive. Here, mice were fed high-fat diet (HFD) supplemented L-NAME for 12 weeks and subsequently intraperitoneally injected EMPA another 4 weeks. A 4D-DIA proteomic assay was performed to detect protein changes failing hearts. We identified 310 differentially...
We developed a risk score for contrast-induced nephropathy (CIN) in elderly patients (n = 668) before percutaneous coronary intervention (PCI). Another 277 were studied validation. Based on the odds ratio, factors assigned weighted integer; sum of integers was score. Among 668 patients, 105 (15.7%) experienced CIN. There 9 CIN (with integer): estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (4), diabetes (3), left ventricular ejection fraction <45% hypotension (2), age >70...
This study aimed to evaluate the relationship between weight-adjusted waist index (WWI) and respiratory symptoms, including cough, wheezing, dyspnea, as well related diseases, namely chronic obstructive pulmonary disease (COPD) asthma, in adults. cross-sectional included 14,760 adults aged over 40 years, drawn from National Health Nutrition Examination Survey (NHANES) conducted 2003 2012. Weighted logistic regression analysis was employed investigate association WWI diseases such COPD...
A high red blood cell distribution width (RDW) at admission or discharge is associated with a worse prognosis in hospitalized patients heart failure (HF), and the prognostic value of in-hospital change RDW (∆RDW) remains debatable.We included 5514 critical illness HF from MIMIC-IV database. The ΔRDW was calculated by minus that admission. Clinical outcomes all-cause mortality 90 day, 180 1 year after discharge. median age 73.91 years, 46.37% were women. Kaplan-Meier curve Cox regression...
Pacing has been proposed as a treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM), but there are few studies long-term follow-up. We evaluated the effects of dual-chamber pacing therapy HOCM, and to identify most prognosis-specific factors predicting outcome in such treating methods.A total 37 HOCM implanted pacemakers were enrolled consecutively followed-up. Thirty-seven cases followed 1 year, 26 2 years, 10 3 eight 4 years. At each annual point follow-up after...
The pattern of neurological recovery in the overall modified Japanese Orthopedic Association scores, upper limb function score, and lower score after surgical decompression for patients suffering from multilevel cervical spondylotic myelopathy (CSM) were analyzed this independent retrospective study.The primary objective study was to compare changes anterior with fusion versus posterior laminoplasty CSM. An additional describe neural speed.Few comparative studies have been conducted evaluate...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to inhibit pyroptosis and apoptosis, which play important roles in the development progression of contrast-induced acute kidney injury (CI-AKI). However, best our knowledge, no studies investigated potential effect PCSK9 on prevalence CI-AKI after percutaneous coronary intervention (PCI). This study aimed determine whether are associated with CI-AKI. The medical records 309 (mean age, 63.35 years; 71.84% male)...
<i>Objective:</i>Gene therapy is defined as the treatment of an acquired or inherited disease by transfer genetic material. The most common strategies in gene bladder cancer are corrective, inductive and cytotoxic therapy. Mutations p53 tumor suppressor molecular abnormalities human cell line adenoviral other vectors was demonstrated to be cytotoxic. However, so far there has been no report adeno-associated virus-2 vector-mediated deliveries cancer. In this study, wild-type cDNA...
Background: To explore the effects of Shenmai (SM) injection on values cardiac output (CO), stroke volume (SV), and ejection fraction (EF) in patients treated with off-pump coronary artery bypass graft (OPCABG). Methods: Forty undergoing OPCABG were randomly divided into SM group (n = 20) 5% glucose (G) 20). The control liquids injected from beginning operation to start (CABG). CO, SV, EF before induction (t1), at (t2), 30 minutes after (t3), (t4), end (CABG) (t5), (t6) recorded. Results: t3...
The clinical effects and safety of release decompression techniques on nerve roots through percutaneous transforaminal endoscopic discectomy (PTED) while treating patients with central lumbar disc herniation (CLDH) were explored. Patient cases leg pain treated in Bethune International Peace Hospital from July 2013 to October 2015 collected retrospectively. these received imaging examinations such as computed tomography magnetic resonance imaging. Among cases, 37 CLDH no other complications...