A5025254723- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Advanced Synthetic Organic Chemistry
- Catalytic Alkyne Reactions
- Synthesis and Catalytic Reactions
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Ferroptosis and cancer prognosis
- Electrochemical Analysis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Radical Photochemical Reactions
- Cyclopropane Reaction Mechanisms
- Machine Learning in Materials Science
- Computational Drug Discovery Methods
- CO2 Reduction Techniques and Catalysts
- Natural product bioactivities and synthesis
- RNA modifications and cancer
Xiamen University
2024
Guangdong Medical College
2021-2022
Massachusetts Institute of Technology
2018-2020
Shanghai Institute of Organic Chemistry
2014-2018
University of Chinese Academy of Sciences
2018
China Pharmaceutical University
2016
Chinese Academy of Sciences
2014-2016
Chimie Biologique pour le Vivant
2016
Shanghai Advanced Research Institute
1993
Electrochemistry offers opportunities to promote single-electron transfer (SET) redox-neutral chemistries similar those recently discovered using visible-light photocatalysis but without the use of an expensive photocatalyst. Herein, we introduce a microfluidic electrochemistry (μRN-eChem) platform that has broad applicability SET chemistry, including radical-radical cross-coupling, Minisci-type reactions, and nickel-catalyzed C(sp2)-O cross-coupling. The cathode anode simultaneously...
Using a mechanically guided ligand design approach, new (SEGFAST) for the CuH-catalyzed hydroamination reaction of unactivated terminal olefins has been developed, providing 62-fold rate increase over reactions compared to DTBM-SEGPHOS, previous optimal ligand. Combining respective strengths computational chemistry and experimental kinetic measurements, we were able quickly identify potential modifications that lead more effective ligands, thus avoiding synthesizing testing large library...
Abstract A unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12‐epi‐hapalindole Q isonitrile, hapalonamide H, deschloro 12‐epi‐fischerindole I nitrile, W as well structural revision latter. Hapalindoles H were also synthesized.
Aplysiasecosterol A (1) is a structurally unusual 9,11-secosteroid isolated from the sea hare Aplysia kurodai. We have accomplished first and asymmetric total synthesis of 1 in convergent fashion. The left-hand segment bearing three adjacent stereocenters was constructed through desymmetrizing reduction, ketalization, radical cyclization. strategy 2-bromoallylation followed by spontaneous lactolization enabled more expeditious access to this segment. right-hand prepared two different...
With recent advances in the computer-aided synthesis planning (CASP) powered by data science and machine learning, modern CASP programs can rapidly identify thousands of potential pathways for a given target molecule. However, lack holistic pathway evaluation mechanism makes it challenging to systematically prioritize strategic except using some simple heuristics. Herein, we introduce data-driven approach evaluate relative levels retrosynthesis dynamic tree-structured long short-term memory...
The first total syntheses of aflavazole (6) and 14-hydroxyaflavinine (8), two sterically congested indole diterpenoids, were accomplished. AlI3-promoted alkyne Prins cyclization was exploited to construct their key structural motifs. An electrocyclization-aromatization sequence assembled the pentasubstituted arene 6, a Stille-Migita coupling furnished tetrasubstituted olefin 8. benzylic allylic C-O bonds reductively cleaved at late stage syntheses, respectively.
The total synthesis of epoxyeujindole A, a structurally unusual indole diterpenoid isolated from Eupenicillium javanicum, has been accomplished for the first time. features late-stage cationic cyclization strategy, which took advantage an electron-rich olefinic substrate. CDE ring system was assembled via enantioselective conjugate addition/alkylation, Luche cyclization, and Nozaki-Hiyama-Kishi reaction. heavily substituted A constructed through Suzuki-Miyaura coupling bridged fused B formed Prins
Here we report the first and concise total synthesis of a complex ophiobolin-derived sesterterpene, bipolarolide D, which hinges on two strategic applications pentafulvene: (1) enantioselective pentafulvene-involved [6+2] cycloaddition; (2) regioselective diastereoselective Heck cyclization. Late-stage selective allylic addition to ketone moiety facilitates successful installation side chain. This strategy enabled accomplishment its through modular approach. will facilitate investigation...
Abstract A unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12‐epi‐hapalindole Q isonitrile, hapalonamide H, deschloro 12‐epi‐fischerindole I nitrile, W as well structural revision latter. Hapalindoles H were also synthesized.
Background The coiled-coil domain containing (CCDC) family proteins have important biological functions in various diseases. However, the 137 (CCDC137) was rarely studied. We aim to investigate role of CCDC137 pan-cancer. Methods expression evaluated RNA sequence profilers pan-cancer and normal tissues from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) database. influence on prognosis tumor patients analyzed using clinical survival data TCGA. Function pathway enrichment...
Arenes with β-stereogenic centers are important substructures in pharmaceuticals and natural products. We have developed an asymmetric anti-Markovnikov hydroarylation of 1,1-disubstituted olefins by dual palladium copper hydride catalysis as a convenient general approach to access these substructures. This efficient one-step process addresses several limitations the traditional stepwise approaches. The use cesium benzoate base common phosphine ligand for both Cu- Pd-catalyzed processes were...
We report herein a protocol for preparing alkynes from alkenyl triflates at ambient temperature with LiCl as promoter.
Abstract Arenes with β‐stereogenic centers are important substructures in pharmaceuticals and natural products. We have developed an asymmetric anti‐Markovnikov hydroarylation of 1,1‐disubstituted olefins by dual palladium copper hydride catalysis as a convenient general approach to access these substructures. This efficient one‐step process addresses several limitations the traditional stepwise approaches. The use cesium benzoate base common phosphine ligand for both Cu‐ Pd‐catalyzed...
Abstract A protocol for preparing alkynes from alkenyl triflates is reported.
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